Search Results - "Akbar, A N"

The convergence of senescence and nutrient sensing during lymphocyte ageing by Akbar, A. N.

“…Summary Immunosurveillance requires the migration of lymphocytes and their activation to induce proliferation and effector function. Effective immunity…”
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Investigation of the cutaneous response to recall antigen in humans in vivo by Akbar, A. N., Reed, J. R., Lacy, K. E., Jackson, S. E., Vukmanovic‐Stejic, M., Rustin, M. H. A.

“…Summary In this paper we provide a detailed description of an experimental method for investigating the induction and resolution of recall immune response to…”
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Interpretation of Mycobacterium tuberculosis antigen-specific IFN-γ release assays (T-SPOT.TB) and factors that may modulate test results by Dheda, K, Pooran, A, Pai, M, Miller, R.F, Lesley, K, Booth, H.L, Scott, G.M, Akbar, A.N, Zumla, A, Rook, G.A

“…Summary Background Data about T cell antigen-specific (ESAT-6 and CFP-10) IFN-γ release assays (IGRAs) during and after completion of anti-tuberculous (TB)…”
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Peripheral generation and function of CD4+CD25+ regulatory T cells by Taams, L S, Akbar, A N

“…The balance between immunity and tolerance is important to maintain immune homeostasis. Several mechanisms are in place to ensure that the immune response is…”
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The Role of the Immune System in Conjunctival Wound Healing After Glaucoma Surgery by Chang, L, Crowston, J.G, Cordeiro, M.Francesca, Akbar, A.N, Khaw, P.T

“…The immune system has a fundamental role in the development and regulation of ocular healing, which plays an important role in the pathogenesis of most…”
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Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis by Vukmanovic-Stejic, M., McQuaid, A., Birch, K.E., Reed, J.R., Macgregor, C., Rustin, M.H.A., Akbar, A.N.

“…Summary Background  It has been established recently that CD4+CD25+ regulatory T cells (Tregs) play an important role in controlling various immune responses…”
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Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells by Akbar, AN, Terry, L, Timms, A, Beverley, PC, Janossy, G

“…A group of mAb recognizing the 200- and/or 220-kDa determinants (CD45R) of the leukocyte common Ag such as 2H4, WR16, MD4.3, and SN130 cross-block each other…”
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Skin resident memory CD8+ T cells are phenotypically and functionally distinct from circulating populations and lack immediate cytotoxic function by Seidel, J. A., Vukmanovic‐Stejic, M., Muller‐Durovic, B., Patel, N., Fuentes‐Duculan, J., Henson, S. M., Krueger, J. G., Rustin, M. H. A., Nestle, F. O., Lacy, K. E., Akbar, A. N.

“…Summary The in‐depth understanding of skin resident memory CD8+ T lymphocytes (TRM) may help to uncover strategies for their manipulation during disease. We…”
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The immunomodulatory effects of regulatory T cells: implications for immune regulation in the skin by Birch, K.E., Vukmanovic-Stejic, M., Reed, J.R., Akbar, A.N., Rustin, M.H.A.

“…Summary Regulatory T cells are thought to have a critical role in the suppression of immune responses. In addition to the prevention of the development of…”
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The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory by AKBAR, A. N, BORTHWICK, N, SALMON, M, GOMBERT, W, BOFILL, M, SHAMSADEEN, N, PILLING, D, PETT, S, GRUNDY, J. E, JANOSSY, G

“…The bcl-2 gene product has been shown to prevent apoptotic cell death. We have now investigated the bcl-2 protein expression by resting and activated mature T…”
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Factors influencing post-cryopreserved CD34+ cells viability in the harvested products of autologous haematopoietic stem cells by Nizam Akbar, N.A., Noor Haslina, M.N., Hassan, M.N., Abdullah, A.D., Husin, A.

“…The cryopreservation process of stem cells potentially cause the loss of CD34+ cells. The aim of this study is to evaluate association of patient, graft and…”
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T lymphocyte mediated lysis of mitomycin C treated Tenon’s capsule fibroblasts by Crowston, J G, Chang, L H, Daniels, J T, Khaw, P T, Akbar, A N

“…Aims: To evaluate the effect of T cell co-culture on mitomycin C treated and untreated Tenon’s capsule fibroblasts. Methods: IL-2 dependent allogeneic T cells…”
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Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts by Crowston, JG, Akbar, AN, Constable, PH, Occleston, NL, Daniels, JT, Khaw, PT

“…To determine whether treatment with mitomycin-c and 5-fluorouracil induces apoptotic death in cultured subconjunctival fibroblasts. Cultured human…”
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Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells by Borthwick, N J, Bofill, M, Gombert, W M, Akbar, A N, Medina, E, Sagawa, K, Lipman, M C, Johnson, M A, Janossy, G

“…The expression of the accessory molecule CD28 was compared in various populations of T and natural killer (NK) cells from HIV-1-negative and HIV-1-positive…”
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Human cytomegalovirus infection up‐regulates interleukin‐8 gene expression and stimulates neutrophil transendothelial migration by CRAIGEN, J. L., YONG, K. L., JORDAN, N. J., MACCORMAC, L. P., WESTWICK, J., AKBAR, A. N., GRUNDY, J. E.

“…Virus‐induced alterations in the cellular expression of chemokines may be important in directing the migration of specific leucocyte subsets to sites of…”
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The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczema by Orteu, C. H., Rustin, M. H. A., O'toole, E., Sabin, C., Salmon, M., Poulter, L. W., Akbar, A. N.

“…Atopic eczema (AE) is characterized by the persistence of infiltrating T lymphocytes in the dermis. To test the hypothesis that dysregulation of normal T cell…”
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In vivo production of interferon β by human Tenon's fibroblasts; a possible mediator for the development of chronic conjunctival inflammation by Chang, L, Siriwardena, D, Wilkins, M R, Crowston, J G, Akbar, A N, Khaw, P T

“…Background: Chronic inflammation may develop from failure of the immune system to deactivate itself during resolution of the wound healing response, and is…”
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Type 1 IFN Maintains the Survival of Anergic CD4+ T Cells by Lombardi, Giovanna, Dunne, Padraic J, Scheel-Toellner, Dagmar, Sanyal, Tina, Pilling, Darrell, Taams, Leonie S, Life, Paul, Lord, Janet M, Salmon, Mike, Akbar, Arne N

“…Anergic T cells have immunoregulatory activity and can survive for extended periods in vivo. It is unclear how anergic T cells escape from deletion, because…”
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Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation by Buckley, Christopher D, Pilling, Darrell, Lord, Janet M, Akbar, Arne N, Scheel-Toellner, Dagmar, Salmon, Mike

“…Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute…”
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Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis‐prone population by Taams, Leonie S., Smith, Jay, Rustin, Malcolm H., Salmon, Mike, Poulter, Len W., Akbar, Arne N.

“…Anergic/suppressive CD4+CD25+ T cells exist in animal models but their presence has not yet been demonstrated in humans. We have identified and characterized a…”
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