Continuous muscle fibre activity: a case treated with acetazolamide

A case is reported of the continuous muscle fibre activity syndrome, which includes a group of disorders characterised by sustained motor unit activity due to hyperactivity of peripheral nerve motor axons. In this patient the muscle stiffness and myokymic movements were successfully treated with ace...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of neurology, neurosurgery and psychiatry Vol. 64; no. 2; pp. 256 - 258
Main Authors:	Çelebı˙soy, Neşe, Çolakoǧlu, Zafer, Akbaba, Yaprak, Yüceyar, Nur
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd 01-02-1998 BMJ BMJ Publishing Group LTD BMJ Group
Subjects:	acetazolamide Acetazolamide - pharmacology Acetazolamide - therapeutic use Adult Ataxia Biological and medical sciences Carbonic Anhydrase Inhibitors - pharmacology continuous muscle fibre activity syndrome Electromyography Fasciculation - complications Female Humans Medical sciences Muscle Fibers, Skeletal - drug effects Muscle Rigidity - complications Muscle Rigidity - drug therapy Muscle, Skeletal - innervation Peripheral Nervous System Diseases - drug therapy Pharmacology. Drug treatments Potassium Rodents Short Report Sodium Urinary system Human Nervous system diseases Sulfonamide Enzyme Acetazolamide Enzyme inhibitor Lyases Case study Chemotherapy Pseudomyotonia Treatment Female Carbonate dehydratase Peripheral nerve disease Carbon-oxygen lyases Hydro-lyases
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A case is reported of the continuous muscle fibre activity syndrome, which includes a group of disorders characterised by sustained motor unit activity due to hyperactivity of peripheral nerve motor axons. In this patient the muscle stiffness and myokymic movements were successfully treated with acetazolamide, which acts as a membrane stabiliser either by blockade of chloride and bicarbonate membrane transport or by producing kaliuresis and raising the transmembrane potential by decreasing extracellular potassium.
Bibliography:	href:jnnp-64-256.pdf PMID:9489543 ark:/67375/NVC-ZR7J0M34-K local:jnnp;64/2/256 Dr Neşe Çelebisoy, Ege University Faculty of Medicine, Department of Neurology, Bornova, I˙zmir, 35100, Turkey. Telephone 00232 3880980; fax 00232 3422141. istex:7EF6A55D6EA0422466174EEDA989B09FA1D34D08 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.64.2.256