Search Results - "Akat, Kemal M."

Single-Cell RNA Profiling of Glomerular Cells Shows Dynamic Changes in Experimental Diabetic Kidney Disease by Fu, Jia, Akat, Kemal M, Sun, Zeguo, Zhang, Weijia, Schlondorff, Detlef, Liu, Zhihong, Tuschl, Thomas, Lee, Kyung, He, John Cijiang

“…Recent single-cell RNA sequencing (scRNA-seq) analyses have offered much insight into cell-specific gene expression profiles in normal kidneys. However, in…”
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Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap by Lee, Youngmin A., Noon, Luke A., Akat, Kemal M., Ybanez, Maria D., Lee, Ting-Fang, Berres, Marie-Luise, Fujiwara, Naoto, Goossens, Nicolas, Chou, Hsin-I, Parvin-Nejad, Fatemeh P., Khambu, Bilon, Kramer, Elisabeth G. M., Gordon, Ronald, Pfleger, Cathie, Germain, Doris, John, Gareth R., Campbell, Kirk N., Yue, Zhenyu, Yin, Xiao-Ming, Cuervo, Ana Maria, Czaja, Mark J., Fiel, M. Isabel, Hoshida, Yujin, Friedman, Scott L.

“…Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains…”
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Deciphering human ribonucleoprotein regulatory networks by Mukherjee, Neelanjan, Wessels, Hans-Hermann, Lebedeva, Svetlana, Sajek, Marcin, Ghanbari, Mahsa, Garzia, Aitor, Munteanu, Alina, Yusuf, Dilmurat, Farazi, Thalia, Hoell, Jessica I, Akat, Kemal M, Akalin, Altuna, Tuschl, Thomas, Ohler, Uwe

“…Abstract RNA-binding proteins (RBPs) control and coordinate each stage in the life cycle of RNAs. Although in vivo binding sites of RBPs can now be determined…”
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Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition by Mong, Ezinne F., Yang, Ying, Akat, Kemal M., Canfield, John, VanWye, Jeffrey, Lockhart, John, Tsibris, John C. M., Schatz, Frederick, Lockwood, Charles J., Tuschl, Thomas, Kayisli, Umit A., Totary-Jain, Hana

“…During implantation, cytotrophoblasts undergo epithelial-to-mesenchymal transition (EMT) as they differentiate into invasive extravillous trophoblasts (EVTs)…”
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Unique microRNAs appear at different times during the course of a delayed-type hypersensitivity reaction in human skin by Gulati, Nicholas, Løvendorf, Marianne B., Zibert, John R., Akat, Kemal M., Renwick, Neil, Tuschl, Thomas, Krueger, James G.

“…Diphencyprone (DPCP) is a hapten that induces delayed‐type hypersensitivity (DTH) reactions. MicroRNAs (miRNAs) are short non‐coding RNAs that negatively…”
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SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas by Wickramage, Ishani, VanWye, Jeffrey, Max, Klaas, Lockhart, John H., Hortu, Ismet, Mong, Ezinne F., Canfield, John, Lamabadu Warnakulasuriya Patabendige, Hiran M., Guzeloglu-Kayisli, Ozlem, Inoue, Kimiko, Ogura, Atsuo, Lockwood, Charles J., Akat, Kemal M., Tuschl, Thomas, Kayisli, Umit A., Totary-Jain, Hana

“…Hemochorial placentas have evolved defense mechanisms to prevent the vertical transmission of viruses to the immunologically underdeveloped fetus. Unlike…”
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Serum MicroRNA Transcriptomics and Acute Rejection or Recurrent Hepatitis C Virus in Human Liver Allograft Recipients: A Pilot Study by Muthukumar, Thangamani, Akat, Kemal M., Yang, Hua, Schwartz, Joseph E., Li, Carol, Bang, Heejung, Ben-Dov, Iddo Z., Lee, John R., Ikle, David, Demetris, Anthony J., Tuschl, Thomas, Suthanthiran, Manikkam

“…Acute rejection (AR) and recurrent hepatitis C virus (R-HCV) are significant complications in liver allograft recipients. Noninvasive diagnosis of intragraft…”
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Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis by Der, Evan, Ranabothu, Saritha, Suryawanshi, Hemant, Akat, Kemal M, Clancy, Robert, Morozov, Pavel, Kustagi, Manjunath, Czuppa, Mareike, Izmirly, Peter, Belmont, H Michael, Wang, Tao, Jordan, Nicole, Bornkamp, Nicole, Nwaukoni, Janet, Martinez, July, Goilav, Beatrice, Buyon, Jill P, Tuschl, Thomas, Putterman, Chaim

“…Lupus nephritis is a leading cause of mortality among systemic lupus erythematosus (SLE) patients, and its heterogeneous nature poses a significant challenge…”
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Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism by Prosdocimo, Domenick A., Anand, Priti, Liao, Xudong, Zhu, Han, Shelkay, Shamanthika, Artero-Calderon, Pedro, Zhang, Lilei, Kirsh, Jacob, Moore, D'Vesharronne, Rosca, Mariana G., Vazquez, Edwin, Kerner, Janos, Akat, Kemal M., Williams, Zev, Zhao, Jihe, Fujioka, Hisashi, Tuschl, Thomas, Bai, Xiaodong, Schulze, P. Christian, Hoppel, Charles L., Jain, Mukesh K., Haldar, Saptarsi M.

“…The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of…”
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Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation by Trinh, Vincent Quoc-Huy, Lee, Ting-Fang, Lemoinne, Sara, Ray, Kevin C, Ybanez, Maria D, Tsuchida, Takuma, Carter, James K, Agudo, Judith, Brown, Brian D, Akat, Kemal M, Friedman, Scott L, Lee, Youngmin A

“…Organ size is maintained by the controlled proliferation of distinct cell populations. In the mouse liver, hepatocytes in the midlobular zone that are positive…”
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Plasma microRNA Interindividual Variability in Healthy Individuals, Pregnant Women, and an Individual with a Stably Altered Neuroendocrine Phenotype by Max, Klaas E.A., Wang, Victoria R., Chang, Michael S., Liau, Jonathan, Weiss, Zachary R., Morgan, Stephanie, Li, Jenny, Bogardus, Kimberly A., Morozov, Pavel, Suryawanshi, Hemant, Akat, Kemal M., Ben-Dov, Iddo Z., Hurley, Arlene M., Dowd, Kathleen, Williams, Zev, Tuschl, Thomas

“…Abstract Background Extracellular RNAs (exRNAs) in biofluids are amenable to quantitative analysis and proposed as noninvasive biomarkers for monitoring organ…”
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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo by La Rocca, Gaspare, King, Bryan, Shui, Bing, Li, Xiaoyi, Zhang, Minsi, Akat, Kemal M, Ogrodowski, Paul, Mastroleo, Chiara, Chen, Kevin, Cavalieri, Vincenzo, Ma, Yilun, Anelli, Viviana, Betel, Doron, Vidigal, Joana, Tuschl, Thomas, Meister, Gunter, Thompson, Craig B, Lindsten, Tullia, Haigis, Kevin, Ventura, Andrea

“…Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue…”
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Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis by Akat, Kemal M, Lee, Youngmin A, Hurley, Arlene, Morozov, Pavel, Max, Klaas Ea, Brown, Miguel, Bogardus, Kimberly, Sopeyin, Anuoluwapo, Hildner, Kai, Diacovo, Thomas G, Neurath, Markus F, Borggrefe, Martin, Tuschl, Thomas

“…Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. We performed conventional…”
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Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis by Der, Evan, Ranabothu, Saritha, Suryawanshi, Hemant, Akat, Kemal M., Clancy, Robert, Morozov, Pavel, Kustagi, Manjunath, Czuppa, Mareike, Izmirly, Peter, Belmont, H. Michael, Wang, Tao, Jordan, Nicole, Bornkamp, Nicole, Nwaukoni, Janet, Martinez, July, Goilav, Beatrice, Buyon, Jill P., Tuschl, Thomas, Putterman, Chaim

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SINE RNA of the imprinted miRNA clusters mediate constitutive type III interferon expression and antiviral protection in hemochorial placentas by Wickramage, Ishani, VanWye, Jeffrey, Max, Klaas, Lockhart, John H., Hortu, Ismet, Mong, Ezinne F., Canfield, John, Lamabadu Warnakulasuriya Patabendige, Hiran M., Guzeloglu-Kayisli, Ozlem, Inoue, Kimiko, Ogura, Atsuo, Lockwood, Charles J., Akat, Kemal M., Tuschl, Thomas, Kayisli, Umit A., Totary-Jain, Hana

“…Hemochorial placentas have evolved defense mechanisms to prevent vertical transmission of viruses to the immunologically underdeveloped fetus. Unlike somatic…”
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Serum MicroRNA Transcriptomics and Acute Rejection or Recurrent Hepatitis C Virus in Human Liver Allograft Recipients: A Pilot Study by Muthukumar, Thangamani, Akat, Kemal M., Yang, Hua, Schwartz, Joseph E., Li, Carol, Bang, Heejung, Ben-Dov, Iddo Z., Lee, John R., Ikle, David, Demetris, Anthony J., Tuschl, Thomas, Suthanthiran, Manikkam

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Unique micro RNA s appear at different times during the course of a delayed‐type hypersensitivity reaction in human skin by Gulati, Nicholas, Løvendorf, Marianne B., Zibert, John R., Akat, Kemal M., Renwick, Neil, Tuschl, Thomas, Krueger, James G.

“…Abstract Diphencyprone ( DPCP ) is a hapten that induces delayed‐type hypersensitivity ( DTH ) reactions. Micro RNA s (mi RNA s) are short non‐coding RNA s…”
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Calcium Metabolism in Adults With Severe Aortic Valve Stenosis and Preserved Renal Function by Akat, Kemal, MD, Kaden, Jens Johannes, MD, Schmitz, Fabian, MD, Ewering, Silke, MD, Anton, Anja, Klomfaß, Sebastian, MD, Hoffmann, Rainer, MD, Ortlepp, Jan Rudolf, MD

“…Data suggest a link of aortic stenosis (AS) with calcium and bone metabolism. To further investigate this, the following parameters were analyzed in 38…”
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