Search Results - "Akasofu, Shigeru"

Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation by Beuckmann, Carsten Theodor, Ueno, Takashi, Nakagawa, Makoto, Suzuki, Michiyuki, Akasofu, Shigeru

“…To present results from in vivo studies underlying the preclinical development of lemborexant (E2006), a novel dual orexin (hypocretin) receptor antagonist for…”
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Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease by Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M, de Silva, Rohan

“…Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer's disease (AD). During the course of these…”
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PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo by Okuda, Michiaki, Hijikuro, Ichiro, Fujita, Yuki, Wu, Xiaofeng, Nakayama, Shinichi, Sakata, Yoko, Noguchi, Yuji, Ogo, Makoto, Akasofu, Shigeru, Ito, Yoshimasa, Soeda, Yoshiyuki, Tsuchiya, Nobuhiko, Tanaka, Naoki, Takahashi, Takashi, Sugimoto, Hachiro

“…In tauopathies, a neural microtubule-associated protein tau (MAPT) is abnormally aggregated and forms neurofibrillary tangle. Therefore, inhibition of the tau…”
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Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen–glucose deprivation by Akasofu, Shigeru, Kosasa, Takashi, Kimura, Manami, Kubota, Atsuhiko

“…Donepezil hydrochloride (donepezil: (±)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one monohydrochloride) is a potent acetylcholinesterase…”
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Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl- d-aspartate (NMDA) toxicity by Akasofu, Shigeru, Kimura, Manami, Kosasa, Takashi, Ogura, Hiroo, Sawada, Kohei

“…Donepezil has a neuroprotective effect against oxygen–glucose deprivation injury and glutamate toxicity in cultured cortical neurons. In this study, we further…”
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P4‐695: E2814: A NOVEL ANTI‐TAU THERAPEUTIC ANTIBODY FOR ALZHEIMER'S DISEASE by Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Strand, Catherine, Agarwala, Kishan, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James, De Silva, Rohan

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E2814: A NOVEL ANTI-TAU THERAPEUTIC ANTIBODY FOR ALZHEIMER’S DISEASE by Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Strand, Catherine, Agarwala, Kishan, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James, De Silva, Rohan

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Protective effect of donepezil against Aβ(1-40) neurotoxicity in rat septal neurons by Kimura, Manami, Akasofu, Shigeru, Ogura, Hiroo, Sawada, Kohei

“…Donepezil, a potent acetylcholinesterase (AChE) inhibitor used for the treatment of Alzheimer's disease (AD), is thought to have a neuroprotective effect in AD…”
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Purification and Characterization of a Src-related p57 Protein-tyrosine Kinase from Xenopus Oocytes by Sato, Ken-ichi, Aoto, Mamoru, Mori, Kiyotoshi, Akasofu, Shigeru, Tokmakov, Alexander A., Sahara, Setsuko, Fukami, Yasuo

“…In the previous study (Fukami, Y., Sato, K.-I., Ikeda, K., Kamisango, K., Koizumi, K., and Matsuno, T. (1993) J. Biol. Chem. 268, 1132-1140), we found that an…”
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Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine by Akasofu, Shigeru, Sawada, Kohei, Kosasa, Takashi, Hihara, Hiroe, Ogura, Hiroo, Akaike, Akinori

“…Long-lasting membrane depolarization in cerebral ischemia causes neurotoxicity via increases of intracellular sodium concentration ([Na +] i) and calcium…”
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Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons by Kimura, Manami, Akasofu, Shigeru, Ogura, Hiroo, Sawada, Kohei

“…Donepezil, a potent acetylcholinesterase (AChE) inhibitor used for the treatment of Alzheimer's disease (AD), is thought to have a neuroprotective effect in AD…”
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Protective effect of donepezil against amyloid-beta neurotoxicity in rat septal neurons by Manami Kimura, Shigeru Akasofu, Hiroo Ogura, Kohei Sawada

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Purification and characterization of a Src-related p57 protein-tyrosine kinase from Xenopus oocytes. Isolation of an inactive form of the enzyme and its activation and translocation upon fertilization by Sato, K, Aoto, M, Mori, K, Akasofu, S, Tokmakov, A A, Sahara, S, Fukami, Y

“…In the previous study (Fukami, Y., Sato, K.-I., Ikeda, K., Kamisango, K., Koizumi, K., and Matsuno, T. (1993) J. Biol. Chem. 268, 1132-1140), we found that an…”
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Application of polymer-protected ultrafine platinum particles to the immunological detection of human serum albumin by Uda, T, Kanmei, R, Akasofu, S, Hifumi, E, Ohtaki, M

“…The immunological properties of ultrafine platinum particles protected with poly(methyl acrylate)-co-N-vinyl-2-pyrrolidone, having a group chemically reactive…”
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