Association of Telomere Length and Serum Vitamin D Levels with Type 2 Diabetes Mellitus and its Related Complications: A Possible Future Perspective

Evidence show that shortened telomere length (TL) and low Vitamin D levels can increase the risk of type 2 diabetes mellitus (T2DM) and its associated complications. T2DM has been considered as an age-related disease, it may be associated with TL. The study aimed to evaluate the association of TL an...

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Bibliographic Details
Published in:	Genome integrity Vol. 12; p. 2
Main Authors:	Akash, C, Prabhu, Madhav, Maldar, Arif, Akash, Poornima, Mishra, Sanjay, Madhura, T K, Kumar, Santosh, Patil, Rekha S, Piplani, Shobhit, Smitha, K S
Format:	Journal Article
Language:	English
Published:	England Wolters Kluwer - Medknow 2021
Subjects:	Original type 2 diabetes mellitus Vitamin D Anthropometry glycated hemoglobin telomere length
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Summary:	Evidence show that shortened telomere length (TL) and low Vitamin D levels can increase the risk of type 2 diabetes mellitus (T2DM) and its associated complications. T2DM has been considered as an age-related disease, it may be associated with TL. The study aimed to evaluate the association of TL and Vitamin D levels with complications of T2DM and the impact of Vitamin D on TL in patients with T2DM. This 1-year cross-sectional study was conducted at a tertiary care hospital on 90 patients. Height, weight, body mass index, waist-hip ratio was calculated. Fasting blood sugars, postprandial blood sugar, and glycated hemoglobin (HbA1c) were analyzed. Absolute TL was obtained from quantitative real-time polymerase chain reaction (qPCR). Vitamin D estimation was done by chemiluminescent immunoassay. Descriptive analysis of the data was done using R i386 3.6.3. The study found a positive correlation between TL and Vitamin D levels ( = 0.64; < 0.0001). The interaction with high HbA1c levels and lower levels of Vitamin D led to the shortening of TL ( = 0.0001). The median of TL and mean of Vitamin D levels were significantly less in the diabetic group ( < 0.0001). Vitamin D levels positively affected the TL and its levels had an inverse relation with the HbA1c levels. This association had a significant effect on the shortening of TL. Vitamin D also had a significant association with other diabetic complications that instigated the shortening of TL. Therefore, assessing the role of Vitamin D levels on the shortening of TL can prove to be crucial biomarkers in managing optimal glycemic levels in T2DM patients.
ISSN:	2041-9414 2041-9414
DOI:	10.4103/genint.genint_3_21