Search Results - "Akasaka, Hiroaki"

Cryo-EM structure of the endothelin-1-ETB-Gi complex by Sano, Fumiya K, Akasaka, Hiroaki, Shihoya, Wataru, Nureki, Osamu

“…The endothelin ET B receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ET B signaling induces reactive…”
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Structural insights into the agonist selectivity of the adenosine A3 receptor by Oshima, Hidetaka S., Ogawa, Akiko, Sano, Fumiya K., Akasaka, Hiroaki, Kawakami, Tomoyoshi, Iwama, Aika, Okamoto, Hiroyuki H., Nagiri, Chisae, Wei, Fan-Yan, Shihoya, Wataru, Nureki, Osamu

“…Adenosine receptors play pivotal roles in physiological processes. Adenosine A 3 receptor (A 3 R), the most recently identified adenosine receptor, is…”
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Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study by Kawaguchi, Hiroki, Demizu, Yusuke, Mukumoto, Naritoshi, Ishihara, Takeaki, Miyawaki, Daisuke, Komatsu, Shohei, Akasaka, Hiroaki, Shinoto, Makoto, Shioyama, Yoshiyuki, Nakamura, Katsumasa, Fukumoto, Takumi, Sasaki, Ryohei

“…We aimed to investigate the dosimetric effects of a spacer placed between the pancreas and surrounding gastrointestinal structures in intensity-modulated…”
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Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103 by Iwama, Aika, Kise, Ryoji, Akasaka, Hiroaki, Sano, Fumiya K., Oshima, Hidetaka S., Inoue, Asuka, Shihoya, Wataru, Nureki, Osamu

“…Pyroglutamylated RF-amide peptide (QRFP) is a peptide hormone with a C-terminal RF-amide motif. QRFP selectively activates a class A G-protein-coupled receptor…”
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Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist by Akasaka, Hiroaki, Tanaka, Tatsuki, Sano, Fumiya K., Matsuzaki, Yuma, Shihoya, Wataru, Nureki, Osamu

“…Lysophosphatidic acid receptor 1 (LPA 1 ) is one of the six G protein-coupled receptors activated by the bioactive lipid, lysophosphatidic acid (LPA). LPA 1 is…”
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Titanium Dioxide-Based Nanoparticles to Enhance Radiation Therapy for Cancer: A Literature Review by Nakayama, Masao, Akasaka, Hiroaki, Sasaki, Ryohei, Geso, Moshi

“…Titanium dioxide nanoparticles (TiO2 NPs) have been investigated as one of the potential dose enhancement agents for radiation therapy. The role of TiO2 NPs as…”
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Ultrasound-stimulated Microbubbles for Treatment of Pancreatic Cancer Cells with Radiation and Nanoparticles: In vitro Study by Nakayama, Masao, Noda, Ayaha, Akasaka, Hiroaki, Tominaga, Takahiro, McCorkell, Giulia, Geso, Moshi, Sasaki, Ryohei

“…Purpose: This study aims to investigate the radiation enhancement effects of ultrasound-stimulated microbubbles (USMB) with X-rays and nanoparticles on…”
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Real‐time in vivo dosimetry system based on an optical fiber‐coupled microsized photostimulable phosphor for stereotactic body radiation therapy by Yada, Ryuichi, Maenaka, Kazusuke, Miyamoto, Shuji, Okada, Go, Sasakura, Aki, Ashida, Motoi, Adachi, Masashi, Sato, Tatsuhiko, Wang, Tianyuan, Akasaka, Hiroaki, Mukumoto, Naritoshi, Shimizu, Yasuyuki, Sasaki, Ryohei

“…Purpose To develop an in vivo dosimeter system for stereotactic body radiation therapy (SBRT) that can perform accurate and precise real‐time measurements,…”
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Structural mechanisms of potent lysophosphatidic acid receptor 1 activation by nonlipid basic agonists by Akasaka, Hiroaki, Sano, Fumiya K., Shihoya, Wataru, Nureki, Osamu

“…Lysophosphatidic acid receptor 1 (LPA 1 ) is one of the G protein-coupled receptors activated by the lipid mediator, lysophosphatidic acid (LPA). LPA 1 is…”
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Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo by Nakayama, Masao, Sasaki, Ryohei, Ogino, Chiaki, Tanaka, Tsutomu, Morita, Kenta, Umetsu, Mitsuo, Ohara, Satoshi, Tan, Zhenquan, Nishimura, Yuya, Akasaka, Hiroaki, Sato, Kazuyoshi, Numako, Chiya, Takami, Seiichi, Kondo, Akihiko

“…Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we…”
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Preclinical Evaluation of Bioabsorbable Polyglycolic Acid Spacer for Particle Therapy by Akasaka, Hiroaki, PhD, Sasaki, Ryohei, MD, PhD, Miyawaki, Daisuke, MD, PhD, Mukumoto, Naritoshi, MS, Sulaiman, Nor Shazrina Binti, MD, Nagata, Masaaki, DVM, Yamada, Shigeru, MD, PhD, Murakami, Masao, MD, PhD, Demizu, Yusuke, MD, PhD, Fukumoto, Takumi, MD, PhD

“…Purpose To evaluate the efficacy and safety of a polyglycolic acid (PGA) spacer through physical and animal experiments. Methods and Materials The spacer was…”
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Gold Nanoparticle-Incorporated Molecularly Imprinted Microgels as Radiation Sensitizers in Pancreatic Cancer by Yoshida, Aoi, Kitayama, Yukiya, Kiguchi, Kentaro, Yamada, Takuya, Akasaka, Hiroaki, Sasaki, Ryohei, Takeuchi, Toshifumi

“…Radiation therapy is a powerful approach for treating pancreatic cancer, a representative refractory cancer with a high fatality rate, and efforts have been…”
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Novel artifact‐robust and highly visible zinc solid fiducial marker for kilovoltage x‐ray image‐guided radiation therapy by Wang, Tianyuan, Inubushi, Sachiko, Ikeo, Naoko, Mukai, Toshiji, Okumura, Keisuke, Akasaka, Hiroaki, Yada, Ryuichi, Yoshida, Kenji, Miyawaki, Daisuke, Ishihara, Takeaki, Nakaoka, Ai, Sasaki, Ryohei

“…Purpose To develop a novel biocompatible solid fiducial marker that prevents radiopaque imaging artifacts and also maintains high imaging contrast for…”
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Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells by Salah, Mohammed, Akasaka, Hiroaki, Shimizu, Yasuyuki, Morita, Kenta, Nishimura, Yuya, Kubota, Hikaru, Kawaguchi, Hiroki, Sogawa, Tomomi, Mukumoto, Naritoshi, Ogino, Chiaki, Sasaki, Ryohei

“…Despite recent advances in radiotherapy, radioresistance in patients with pancreatic cancer remains a crucial dilemma for clinical treatment. Cancer stem cells…”
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First-In-Human Phase 1 Study of a Nonwoven Fabric Bioabsorbable Spacer for Particle Therapy: Space-Making Particle Therapy (SMPT) by Sasaki, Ryohei, MD, PhD, Demizu, Yusuke, MD, PhD, Yamashita, Tomohiro, PhD, Komatsu, Shohei, MD, PhD, Akasaka, Hiroaki, PhD, Miyawaki, Daisuke, MD, PhD, Yoshida, Kenji, MD, PhD, Wang, Tianyuan, PhD, Okimoto, Tomoaki, MD, PhD, Fukumoto, Takumi, MD, PhD

“…AbstractPurposeSurgical spacer placement (SSP) is useful in particle therapy (PT) for patients with abdominal or pelvic tumors located adjacent to normal…”
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Respiratory motion tracking of spine stereotactic radiotherapy in prone position by Mizonobe, Kazufusa, Akasaka, Hiroaki, Uehara, Kazuyuki, Oki, Yuya, Nakayama, Masao, Tamura, Shuhei, Munetomo, Yoshiki, Kubo, Katsumaro, Kawaguchi, Hiroki, Harada, Aya, Mayahara, Hiroshi

“…Purpose The CyberKnife system is a specialized device for non‐coplanar irradiation; however, it possesses the geometric restriction that the beam cannot be…”
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Radiosensitization effects and ROS generation by high Z metallic nanoparticles on human colon carcinoma cell (HCT116) irradiated under 150 MeV proton beam by Abdul Rashid, Raizulnasuha, Zainal Abidin, Safri, Khairil Anuar, Muhammad Afiq, Tominaga, Takahiro, Akasaka, Hiroaki, Sasaki, Ryohei, Kie, Katahira, Abdul Razak, Khairunisak, Pham, Binh. T.T., Hawkett, Brian S., Carmichael, Mary-Ann, Geso, Moshi, Rahman, Wan Nordiana

“…•High Z metallic nanoparticles have the potential to be applied as radiosensitizer in proton beam therapy.•AuNPs, SPIONs, PtNDs and BiNRs under irradiation…”
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Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells by Akasaka, Hiroaki, Sasaki, Ryohei, Yoshida, Kenji, Takayama, Izumi, Yamaguchi, Toyofumi, Yoshida, Hiromi, Mizushina, Yoshiyuki

“…Gemcitabine (GEM) is used to treat various carcinomas and represents an advance in pancreatic cancer treatment. In the screening for DNA polymerase (pol)…”
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Plan comparison of prostate stereotactic radiotherapy in spacer implant patients by Oki, Yuya, Uehara, Kazuyuki, Mizonobe, Kazufusa, Akasaka, Hiroaki, Shiota, Yuichirou, Sakamoto, Risako, Harada, Aya, Kitatani, Keiji, Yabuuchi, Tomonori, Miyazaki, Shuichirou, Hattori, Takayuki, Mayahara, Hiroshi

“…In prostate stereotactic body radiation therapy (SBRT), hydrogel spacers are increasingly used. This study aimed to perform a dosimetry comparison of treatment…”
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MGDG extracted from spinach enhances the cytotoxicity of radiation in pancreatic cancer cells by Akasaka, Hiroaki, Mizushina, Yoshiyuki, Yoshida, Kenji, Ejima, Yasuo, Mukumoto, Naritoshi, Wang, Tianyuan, Inubushi, Sachiko, Nakayama, Masao, Wakahara, Yuki, Sasaki, Ryohei

“…In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study…”
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