Beneficial Effects of Long-Term Consumption of a Probiotic Combination of Lactobacillus casei Shirota and Bifidobacterium breve Yakult May Persist After Suspension of Therapy in Lactose-Intolerant Patients

Beneficial Effects of Long-Term Consumption of a Probiotic Combination of Lactobacillus casei Shirota and Bifidobacterium breve Yakult May Persist After Suspension of Therapy in Lactose-Intolerant Patients

Background: The efficacy of some probiotic strains for the management of lactose intolerance remains to be established. Aim :To evaluate the effects of a 4-week consumption of a probiotic product containing Lactobacillus casei Shirota and Bifidobacterium breve Yakult (107–109 CFU of each strain) on...

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Bibliographic Details
Published in:Nutrition in clinical practice Vol. 27; no. 2; pp. 247 - 251
Main Authors: Almeida, Camila Casuccio, Lorena, Sônia Letícia Silva, Pavan, Célia Regina, Akasaka, Helena Midori Imamura, Mesquita, Maria Aparecida
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-04-2012
Subjects:
Adult
Area Under Curve
Bifidobacterium
Breath Tests
Dietary Supplements
Digestion
Exhalation
Female
Humans
Hydrogen - metabolism
Lactobacillus casei
Lactose - metabolism
lactose intolerance
Lactose Intolerance - complications
Lactose Intolerance - drug therapy
Lactose Intolerance - metabolism
Male
Middle Aged
Nursing
probiotics
Probiotics - administration & dosage
Probiotics - therapeutic use
lactose intolerance
probiotics
breath tests
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Summary:Background: The efficacy of some probiotic strains for the management of lactose intolerance remains to be established. Aim :To evaluate the effects of a 4-week consumption of a probiotic product containing Lactobacillus casei Shirota and Bifidobacterium breve Yakult (107–109 CFU of each strain) on symptoms and breath hydrogen exhalation after a lactose load in lactose-intolerant patients and whether the beneficial results persisted after probiotic discontinuation. Methods: Twenty-seven patients with lactose maldigestion and intolerance participated in this study, which comprised 4 hydrogen breath tests: baseline condition (20 g lactose), after lactase ingestion (9000 FCC units), at the end of 4-week probiotic supplementation, and a follow-up test performed 3 months after probiotic discontinuation. For each test, the area under the breath hydrogen concentration vs time curve (AUC180 min) was calculated, and symptom scores were recorded. Results: The probiotic combination significantly reduced symptom scores (P < .01) and breath hydrogen AUC (P = .04) compared with the baseline condition. The comparison with the lactase test showed that symptom scores were similar (P > .05), despite the significantly higher (P = .01) AUC values after probiotic use. In the follow-up test, symptom scores and breath hydrogen AUC values remained similar to those found at the end of probiotic intervention. Conclusion: Four-week consumption of a probiotic combination of L casei Shirota and B breve Yakult seems to improve symptoms and decrease hydrogen production intake in lactose-intolerant patients. These effects may persist for at least 3 months after suspension of probiotic consumption.
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ISSN:0884-5336
1941-2452
DOI:10.1177/0884533612440289