Search Results - "Akarid, Khadija"
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RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux
Published in Cell death & disease (25-04-2019)“…Early detection of viruses by the innate immune system is crucial for host defense. The NLRP3 inflammasome, through activation of caspase-1, promotes the…”
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Dissecting Platelet's Role in Viral Infection: A Double-Edged Effector of the Immune System
Published in International journal of molecular sciences (19-01-2023)“…Platelets play a major role in the processes of primary hemostasis and pathological inflammation-induced thrombosis. In the mid-2000s, several studies expanded…”
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Inhibiting human and 'Leishmania' arginases using 'Cannabis sativa' as a potential therapy for cutaneous leishmaniasis: A molecular docking study
Published in Tropical medicine and infectious disease (26-11-2022)“…Cutaneous leishmaniasis (CL), a vector-borne parasitic disease caused by the 'Leishmania' protozoan, is a serious public health problem in Morocco. The…”
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Molecular identification of Leishmania infection in the most relevant sand fly species and in patient skin samples from a cutaneous leishmaniasis focus, in Morocco
Published in PLoS neglected tropical diseases (02-03-2018)“…Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of Leishmania and transmitted by several species of sand flies. CL is among the…”
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Mix-and-match COVID-19 vaccines trigger high antibody response after the third dose vaccine in Moroccan health care workers
Published in Vaccine: X (01-08-2023)“…Recent studies have shown that in individuals who have received two doses of COVID-19 vaccine, the level of IgG antibodies decreased over time. In addition,…”
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Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous Leishmania
Published in Frontiers in cellular and infection microbiology (04-10-2019)“…Disease manifestation after infection with cutaneous species is the result of a complex interplay of diverse factors, including the immune status of the host,…”
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Moroccan strains of Leishmania major and Leishmania tropica differentially impact on nitric oxide production by macrophages
Published in Parasites & vectors (23-10-2017)“…Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by protozoa of the genus Leishmania. In Morocco, CL is a public health problem mainly…”
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Anti-SARS-CoV-2 Antibody Responses 5 Months Post Complete Vaccination of Moroccan Healthcare Workers
Published in Vaccines (Basel) (18-03-2022)“…Data about the duration of antibodies after vaccination show that the protection against SARS-CoV-2 infection begins to decline over time. This study aims to…”
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Environmental, Climatic, and Parasite Molecular Factors Impacting the Incidence of Cutaneous Leishmaniasis Due to Leishmania tropica in Three Moroccan Foci
Published in Microorganisms (Basel) (25-08-2022)“…Cutaneous leishmaniasis (CL) occurring due to Leishmania tropica is a public health problem in Morocco. The distribution and incidence of this form of…”
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IL-1 Polymorphism and Helicobacter pylori Infection Features: Highlighting VNTR's Potential in Predicting the Susceptibility to Infection-Associated Disease Development
Published in Microorganisms (Basel) (31-01-2023)“…Genetic polymorphisms at the IL-1 cluster are associated with increased ( )-associated disease risk in an ethnically dependent manner. Due to the corroborated…”
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Possible introduction of Leishmania tropica to urban areas determined by epidemiological and clinical profiles of patients with cutaneous leishmaniasis in Casablanca (Morocco)
Published in Parasite epidemiology and control (01-05-2020)“…Leishmaniases are a group of infectious diseases caused by protozoan Leishmania parasites and are transmitted by the bites of infected phlebotomine sandflies…”
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The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of Leishmania major and Leishmania tropica Is Not Associated with p47phox Phosphorylation
Published in Microorganisms (Basel) (10-05-2021)“…Polymorphonuclear neutrophils (PMNs) are the first phagocyte recruited and infected by Leishmania. They synthetize superoxide anions (O2−) under the control of…”
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Leishmania major-mediated prevention of programmed cell death induction in infected macrophages is associated with the repression of mitochondrial release of cytochrome c
Published in Journal of leukocyte biology (01-07-2004)“…Leishmania are obligate, intracellular parasites of macrophages in their vertebrate hosts, including humans, in which they cause disease. Here, we report that…”
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14
CD95 engagement induces disseminated endothelial cell apoptosis in vivo: immunopathologic implications
Published in Blood (15-04-2002)“…Fas (CD95) is a death receptor involved in apoptosis induction on engagement by Fas ligand (CD95L). Although CD95L-mediated apoptosis has been proposed as a…”
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15
The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?
Published in Microbial pathogenesis (01-04-2021)“…The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in…”
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Tissue tropism: Is it an intrinsic characteristic of Leishmania species?
Published in Acta tropica (01-08-2022)“…•To visceralize, Leishmania faces skin immunity and harsh conditions in deep organs.•Viscerotropic and dermotropic Leishmania spp are genetically…”
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Kinetics of specific anti-SARS-CoV-2 IgM, IgA, and IgG responses during the first 12 months after SARS-CoV-2 infection: A prospective longitudinal study
Published in PloS one (12-07-2023)“…Coronavirus 2019 (COVID-19) is a global health threat. The kinetics of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) need to…”
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Genetic variations in Interferon-Induced with Helicase C Domain 1: Impact on COVID-19 risk and severity in the Moroccan population
Published in Human immunology (01-11-2024)“…The clinical spectrum of COVID-19 varies considerably, ranging from asymptomatic cases to severe disease and even death. This variability can partly be…”
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The different faces of the NLRP3 inflammasome in cutaneous Leishmaniasis: A review
Published in Cytokine (Philadelphia, Pa.) (01-11-2021)“…•NLRP3 inflammasome activation elicits the IL-1βIL production.•This innate complex is involved in Cutaneous leishmaniasis (CL) physiopathology.•NLRP3…”
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Targeting IL-1β in patients with advanced Helicobacter pylori infection: a potential therapy for gastric cancer
Published in Future microbiology (01-05-2022)“…( ) infection is a causal factor of gastric cancer. Among the cytokines secreted during this infection, IL-1β is highly associated with promotion and…”
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