Secretory Capacity of Pancreatic Beta-Cells Is Enhanced 6 Months After Renal Denervation in Hypertensive Patients

Secretory Capacity of Pancreatic Beta-Cells Is Enhanced 6 Months After Renal Denervation in Hypertensive Patients

A bidirectional relationship is known between increased sympathetic activity inducing insulin resistance and hyperinsulinemia producing sympathetic overactivity, resulting in a vicious circle (1). [...]it seems likely that renal denervation (RDN), introduced as an interventional approach for lowerin...

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Bibliographic Details
Published in:Journal of the American College of Cardiology Vol. 72; no. 25; pp. 3372 - 3374
Main Authors: Ott, Christian, Schmid, Axel, Mahfoud, Felix, Akarca, Ertan, Kistner, Iris, Ditting, Tilmann, Veelken, Roland, Böhm, Michael, Uder, Michael, Schmieder, Roland E.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 25-12-2018
Elsevier Limited
Subjects:
Ablation
Aged
Blood pressure
Blood Pressure - physiology
Cardiology
Denervation
Denervation - trends
Diabetes
Fasting
Female
Glucagon
Glucose
Hemoglobin
Homeostasis
Humans
Hyperinsulinemia
Hypertension
Hypertension - diagnosis
Hypertension - metabolism
Hypertension - surgery
Insulin
Insulin resistance
Insulin-Secreting Cells - metabolism
Kidney - innervation
Kidney - surgery
Kidneys
Male
Middle Aged
Pancreas
Patients
Peptides
Pilot Projects
Prospective Studies
Time Factors
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Summary:A bidirectional relationship is known between increased sympathetic activity inducing insulin resistance and hyperinsulinemia producing sympathetic overactivity, resulting in a vicious circle (1). [...]it seems likely that renal denervation (RDN), introduced as an interventional approach for lowering blood pressure (BP), may also have an impact on glucose homeostasis (2). [...]the objective of the study was to analyze whether RDN improves beta-cell secretory capacity. None of our patients received any glucose-lowering agent. Because glucagon directly stimulates beta-cells, the change of C-peptide concentrations by the glucagon test is a valid index of secretory capacity of beta-cells, reflecting functional beta-cell mass.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2018.09.075