Search Results - "Akao, Atsushi"

Efficient Synthesis of 1,4-Diaryl-5-methyl-1,2,3-triazole, A Potential mGluR1 Antagonist, and the Risk Assessment Study of Arylazides by Tsuritani, Takayuki, Mizuno, Hiroo, Nonoyama, Nobuaki, Kii, Satoshi, Akao, Atsushi, Sato, Kimihiko, Yasuda, Nobuyoshi, Mase, Toshiaki

“…A concise and practical synthesis of a 1,4-diaryl-5-methyl-1,2,3-triazole is described. A mGluR1 antagonist 1 was prepared with one-pot operation by the…”
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Highly chemoselective reduction using a Rh/C–Fe(OAc) 2 system: practical synthesis of functionalized indoles by Akao, Atsushi, Sato, Kimihiko, Nonoyama, Nobuaki, Mase, Toshiaki, Yasuda, Nobuyoshi

“…Here, we report a highly effective and chemoselective method of preparing substituted indoles from ( E)-2-nitropyrrolidinostyrenes via hydrogenation in the…”
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Synthesis of a Muscarinic Receptor Antagonist via a Diastereoselective Michael Reaction, Selective Deoxyfluorination and Aromatic Metal−Halogen Exchange Reaction by Mase, Toshiaki, Houpis, Ioannis N, Akao, Atsushi, Dorziotis, Ilias, Emerson, Khateeta, Hoang, Thoa, Iida, Takehiko, Itoh, Takahiro, Kamei, Keisuke, Kato, Shinji, Kato, Yoshiaki, Kawasaki, Masashi, Lang, Fengrui, Lee, Jaemoon, Lynch, Joseph, Maligres, Peter, Molina, Audrey, Nemoto, Takayuki, Okada, Shigemitsu, Reamer, Robert, Song, Jake Z, Tschaen, David, Wada, Toshihiro, Zewge, Daniel, Volante, R. P, Reider, Paul J, Tomimoto, Koji

“…An efficient synthesis of a structurally unique, novel M3 antagonist 1 is described. Compound 1 is conveniently disconnected retrosynthetically at the amide…”
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Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs by Kigoshi, Hideo, Suenaga, Kiyotake, Takagi, Masaki, Akao, Atsushi, Kanematsu, Kengo, Kamei, Noriyuki, Okugawa, Youko, Yamada, Kiyoyuki

“…Artificial analogs of aplyronine A ( 1 ), a potent antitumor macrolide, were synthesized and structure–activity (cytotoxicity and actin-depolymerizing…”
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Practical synthesis of a potent indolocarbazole-based, DNA topoisomerase inhibitor by Akao, Atsushi, Hiraga, Shouichi, Iida, Takehiko, Kamatani, Asayuki, Kawasaki, Masashi, Mase, Toshiaki, Nemoto, Takayuki, Satake, Nobuya, Weissman, Steven A, Tschaen, David M, Rossen, Kai, Petrillo, Daniel, Reamer, Robert A, Volante, R.P

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Practical Asymmetric Synthesis of a Selective Endothelin A Receptor (ETA) Antagonist by Song, Zhiguo J, Zhao, Matthew, Frey, Lisa, Li, Jing, Tan, Lushi, Chen, Cheng Y, Tschaen, David M, Tillyer, Richard, Grabowski, Edward J. J, Volante, Ralph, Reider, Paul J, Kato, Yoshiaki, Okada, Shigemitsu, Nemoto, Takayuki, Sato, Hiroki, Akao, Atsushi, Mase, Toshiaki

“…A practical, chromotography-free asymmetric synthesis was developed for the large scale preparation of an endothelin receptor antagonist 2. This synthesis…”
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Asymmetric synthesis of a selective endothelin A receptor antagonist by Kato, Yoshiaki, Niiyama, Kenji, Nemoto, Takayuki, Jona, Hideki, Akao, Atsushi, Okada, Shigemitsu, Song, Zhiguo J, Zhao, Matthew, Tsuchiya, Yoshimi, Tomimoto, Koji, Mase, Toshiaki

“…An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. A highly substituted pyridine intermediate 11a was efficiently…”
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Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs by Suenaga, Kiyotake, Kamei, Noriyuki, Okugawa, Youko, Takagi, Masaki, Akao, Atsushi, Kigoshi, Hideo, Yamada, Kiyoyuki

“…The artificial analogs of aplyronine A ( 1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin…”
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Asymmetric Synthesis of a Selective Endothelin A Receptor Antagonist by Kato, Yoshiaki, Niiyama, Kenji, Jona, Hideki, Okada, Shigemitsu, Akao, Atsushi, Hiraga, Shouichi, Tsuchiya, Yoshimi, Tomimoto, Koji, Mase, Toshiaki

“…An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. Asymmetric conjugate addition of aryllithium derived from 18 to the…”
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A mild and practical deprotection method for benzyl thioethers by Akao, Atsushi, Nonoyama, Nobuaki, Yasuda, Nobuyoshi

“…A highly effective and mild deprotection method was developed for benzyl thioethers using dibutylmagnesium in the presence of a catalytic amount of titanocene…”
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Development of Large-Scale Preparations of Indole Derivatives:  Evaluation of Potential Thermal Hazards and Studies of Reaction Kinetics and Mechanisms by Akao, Atsushi, Nonoyama, Nobuaki, Mase, Toshiaki, Yasuda, Nobuyoshi

“…Hydrogenation of (E)-2-nitropyrrolidinostyrene in the presence of the doped rhodium catalyst is safe, scalable, and highly effective for the preparation of…”
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An Efficient and Scalable Synthesis of Substituted Phenanthrenequinones by Intramolecular Friedel−Crafts Reaction of Imidazolides by Yoshikawa, Naoki, Doyle, Austin, Tan, Lushi, Murry, Jerry A, Akao, Atsushi, Kawasaki, Masashi, Sato, Kimihiko

“…An efficient synthesis of 9,10-phenanthrenequinones is described. The two carbonyl groups were introduced by an orthoselective intermolecular Friedel−Crafts…”
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Bromine–magnesium exchange of 5-bromo-2-picoline via an organomagnesium complex nBu2iPrMgLi: a new preparation methodology of functionalized picolines under noncryogenic conditions by Kii, Satoshi, Akao, Atsushi, Iida, Takehiko, Mase, Toshiaki, Yasuda, Nobuyoshi

“…The organomagnesium complex nBu2iPrMgLi, readily prepared from nBuLi and iPrMgCl (2:1), is quite efficient for the bromine–magnesium exchange of…”
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Synthesis of a Muscarinic Receptor Antagonist via a Diastereoselective Michael Reaction, Selective Deoxyfluorination and Aromatic Metal-Halogen Exchange Reaction by Mase, Toshiaki, Houpis, Ioannis N, Akao, Atsushi, Dorziotis, Ilias, Emerson, Khateeta, Hoang, Thoa, Iida, Takehiko, Itoh, Takahiro, Kamei, Keisuke, Kato, Shinji, Kawasaki, Masashi, Lang, Fengrui, Lee, Jaemoon, Lynch, Joseph, Maligres, Peter, Molina, Audrey, Nemoto, Takayuki, Okada, Shigemitsu, Reamer, Robert, Song, Zhiguo J, Tschaen, David, Wada, Toshihiro, Zewge, David, Volante, R. P, Reider, Paul J, Tomimoto, Koji

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