Search Results - "Akamizu, T"

Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases by Inoue, N, Watanabe, M, Morita, M, Tomizawa, R, Akamizu, T, Tatsumi, K, Hidaka, Y, Iwatani, Y

“…The severity of Hashimoto's disease (HD) and intractability (or inducibility to remission) of Graves' disease (GD) varies among patients. Forkhead box P3…”
Get full text

Association of the -31C/T functional polymorphism in the interleukin-1β gene with the intractability of Graves' disease and the proportion of T helper type 17 cells by Hayashi, F, Watanabe, M, Nanba, T, Inoue, N, Akamizu, T, Iwatani, Y

“…Interleukin (IL)-1β is a proinflammatory cytokine and has been implicated in the pathogenesis of several autoimmune diseases. To evaluate the hypothesis that…”
Get full text

Association of functional polymorphisms in promoter regions of IL5, IL6 and IL13 genes with development and prognosis of autoimmune thyroid diseases by Inoue, N, Watanabe, M, Morita, M, Tatusmi, K, Hidaka, Y, Akamizu, T, Iwatani, Y

“…To clarify the association of genetic producibility of interleukin (IL)-5, IL-6 and IL-13, which are secreted by T helper type 2 (Th2), with the development…”
Get full text

869T/C polymorphism in the transforming growth factor-β1 gene is associated with the severity and intractability of autoimmune thyroid disease by Yamada, H, Watanabe, M, Nanba, T, Akamizu, T, Iwatani, Y

“…The severity of Hashimoto's disease (HD) and the intractability of Graves' disease (GD) vary among patients. To clarify whether the +869T/C polymorphism in the…”
Get full text

Improvement of meal‐related symptoms and epigastric pain in patients with functional dyspepsia treated with acotiamide was associated with acylated ghrelin levels in Japan by Yamawaki, H., Futagami, S., Kawagoe, T., Maruki, Y., Hashimoto, S., Nagoya, H., Sato, H., Kodaka, Y., Gudis, K., Akamizu, T., Sakamoto, C., Iwakiri, K.

“…Background The aim of this study is to clarify whether acotiamide and rabeprazole combination therapy can improve clinical symptoms, gastric emptying, and…”
Get full text

The +869T/C polymorphism in the transforming growth factor- beta 1 gene is associated with the severity and intractability of autoimmune thyroid disease by Yamada, H, Watanabe, M, Nanba, T, Akamizu, T, Iwatani, Y

“…The severity of Hashimoto's disease (HD) and the intractability of Graves' disease (GD) vary among patients. To clarify whether the +869T/C polymorphism in the…”
Get full text

Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects by AKAMIZU, Takashi, TAKAYA, Kazuhiko, YOKODE, Masayuki, TANAKA, Koichi, KANGAWA, Kenji, IRAKO, Taiga, HOSODA, Hiroshi, TERAMUKAI, Satoshi, MATSUYAMA, Akiko, TADA, Harue, MIURA, Kazumi, SHIMIZU, Akira, FUKUSHIMA, Masanori

“…It has been demonstrated that ghrelin plays a major role in the regulation of GH secretion and food intake. These actions make ghrelin a strong candidate for…”
Get full text

Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody by Inoue, N, Watanabe, M, Nanba, T, Wada, M, Akamizu, T, Iwatani, Y

“…The severity of Hashimoto's disease (HD) and intractability of Graves' disease (GD) varies among patients. Severity of HD is associated with the functional…”
Get full text

PO371 NEEDS OF PHARMACEUTICAL PAIN THERAPY IN JAPANESE DIABETIC PATIENTS MIGHT BE HIGHER THAN PHYSICIANS' EXPECTATION by Sasaki, H, Kurisu, S, Ogawa, K.-i, Tanaka, H, Arita, M, Akamizu, T, Nishi, M, Furuta, H, Nanjio, K

Get full text

Association of functional GITR gene polymorphisms related to expression of glucocorticoid‐induced tumour necrosis factor‐receptor (GITR) molecules with prognosis of autoimmune thyroid disease by Tomizawa, R., Watanabe, M., Inoue, N., Takemura, K., Hidaka, Y., Akamizu, T., Hayakawa, K., Iwatani, Y.

“…Summary The glucocorticoid‐induced tumour necrosis factor (TNF)‐receptor (GITR) affects the functions of regulatory T (Treg) and effector T (Teff) cells, but…”
Get full text

Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure by Akamizu, T, Murayama, T, Teramukai, S, Miura, K, Bando, I, Irako, T, Iwakura, H, Ariyasu, H, Hosoda, H, Tada, H, Matsuyama, A, Kojima, S, Wada, T, Wakatsuki, Y, Matsubayashi, K, Kawakita, T, Shimizu, A, Fukushima, M, Yokode, M, Kangawa, K

“…Aging is associated with a decrease in growth hormone (GH) secretion, appetite and energy intake. As ghrelin stimulates both GH secretion and appetite,…”
Get full text

Antithyrotropin receptor antibody: an update by Akamizu, T

“…Numerous studies have reported the characteristics and significance concerning antithyrotropin receptor antibodies (TSHR-Abs), which cause Graves' disease and…”
Get more information

Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats by IRAKO, T, AKAMIZU, T, HOSODA, H, IWAKURA, H, ARIYASU, H, TOJO, K, TAJIMA, N, KANGAWA, K

Get full text

Monoclonal Antibodies to Thyroid Specific Autoantigens by Akamizu, Takashi

“…Monoclonal antibody (MAbs) is a powerful and essential tool to perform studies concerning antigens and antibodies at molecular level. MAbs to major thyroid…”
Get full text

A case of type 2 diabetes with abrupt-onset hypoglycemia due to anti-insulin antibody: Immunological change evaluated by Scatchard analysis during successful treatment by the exchange from human insulin to insulin analogue by Osawa, K, Nakagawa, T, Sasaki, H, Wakasaki, H, Furuta, H, Nishi, M, Nanjo, K, Akamizu, T

Get full text

Drug‐induced neutropenia associated with anti‐neutrophil cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicity by Akamizu, T., Ozaki, S., Hiratani, H., Uesugi, H., Sobajima, J., Hataya, Y., Kanamoto, N., Saijo, M., Hattori, Y., Moriyama, K., Ohmori, K., Nakao, K.

“…SUMMARY Although antineutrophil antibodies are thought to be involved in drug‐induced neutropenia, neither the precise mechanisms nor the particular antigens…”
Get full text

Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients by Akamizu, T, Sale, M M, Rich, S S, Hiratani, H, Noh, J Y, Kanamoto, N, Saijo, M, Miyamoto, Y, Saito, Y, Nakao, K, Bowden, D W

“…In a previous study we identified a microsatellite marker near the thyrotropin receptor (TSHR) gene. Studies with this marker, TSHR-CA, revealed a significant…”
Get more information

International Consensus Guidance Statement on the Management and Treatment of IgG4‐Related Disease by Khosroshahi, A., Wallace, Z. S., Crowe, J. L., Akamizu, T., Azumi, A., Carruthers, M. N., Chari, S. T., Della‐Torre, E., Frulloni, L., Goto, H., Hart, P. A., Kamisawa, T., Kawa, S., Kawano, M., Kim, M. H., Kodama, Y., Kubota, K., Lerch, M. M., Löhr, M., Masaki, Y., Matsui, S., Mimori, T., Nakamura, S., Nakazawa, T., Ohara, H., Okazaki, K., Ryu, J.H., Saeki, T., Schleinitz, N., Shimatsu, A., Shimosegawa, T., Takahashi, H., Takahira, M., Tanaka, A., Topazian, M., Umehara, H., Webster, G. J., Witzig, T. E., Yamamoto, M., Zhang, W., Chiba, T., Stone, J. H.

Get full text

Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains by KOSUGI, S, BAN, T, AKAMIZU, T, KOHN, L. D

“…Residues 287 to 404 of the rat thyrotropin (TSH) receptor exhibit little homology to gonadotropin receptors. A large segment of this region, residues 303-382,…”
Get full text

Cloning, Chromosomal Assignment, and Regulation of the Rat Thyrotropin Receptor: Expression of the Gene is Regulated by Thyrotropin, Agents that Increase cAMP Levels, and Thyroid Autoantibodies by Akamizu, Takashi, Ikuyama, Shoichiro, Saji, Motoyasu, Kosugi, Shinji, Kozak, Christine, McBride, O. Wesley, Kohn, Leonard D.

“…A rat thyrotropin (thyroid-stimulating hormone, TSH) receptor cDNA was isolated that encoded a protein of 764 amino acids, Mr86,528. Transfection of the cDNA…”
Get full text