Search Results - "Akamine, Tomoyo"

SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy by Kawanami, Daiji, Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Akamine, Tomoyo, Yokota, Tamotsu, Sango, Kazunori, Utsunomiya, Kazunori

“…Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) worldwide. Glycemic and blood pressure (BP) control are important but not…”
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ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells by Takeda, Yusuke, Matoba, Keiichiro, Kawanami, Daiji, Nagai, Yosuke, Akamine, Tomoyo, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori

“…The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various cellular functions, including organization of the actin cytoskeleton,…”
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Rho-Kinase Blockade Attenuates Podocyte Apoptosis by Inhibiting the Notch Signaling Pathway in Diabetic Nephropathy by Matoba, Keiichiro, Kawanami, Daiji, Nagai, Yosuke, Takeda, Yusuke, Akamine, Tomoyo, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori

“…Podocyte apoptosis is a key process in the onset of diabetic nephropathy. A significant body of evidence shows that the Notch signaling pathway plays a central…”
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Glycolaldehyde induces sensory neuron death through activation of the c-Jun N-terminal kinase and p-38 MAP kinase pathways by Akamine, Tomoyo, Takaku, Shizuka, Suzuki, Mari, Niimi, Naoko, Yako, Hideji, Matoba, Keiichiro, Kawanami, Daiji, Utsunomiya, Kazunori, Nishimura, Rimei, Sango, Kazunori

“…Glycolaldehyde (GA) is a highly reactive hydroxyaldehyde and one of the glycolytic metabolites producing advanced glycation endproducts (AGEs), but its…”
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Glycolaldehyde induces sensory neuron death through activation of the c-Jun N-terminal kinase and p-38 MAP kinase pathways by Akamine, Tomoyo, Takaku, Shizuka, Suzuki, Mari, Niimi, Naoko, Yako, Hideji, Matoba, Keiichiro, Kawanami, Daiji, Utsunomiya, Kazunori, Nishimura, Rimei, Sango, Kazunori

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ROCK2 regulates TGF-β-induced expression of CTGF and profibrotic genes via NF-κB and cytoskeleton dynamics in mesangial cells by Nagai, Yosuke, Matoba, Keiichiro, Kawanami, Daiji, Takeda, Yusuke, Akamine, Tomoyo, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…The small GTPase Rho and its effector Rho kinase (ROCK) are involved in the pathogenesis of diabetic kidney disease. Rho kinase has two isoforms: ROCK1 and…”
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392-P: ROCK2-Mediated Podocyte Dysfunction in Diabetic Nephropathy by MATOBA, KEIICHIRO, TAKEDA, YUSUKE, AKAMINE, TOMOYO, NAGAI, YOSUKE, UKICHI, RIKAKO, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase RhoA and its downstream effector, Rho-kinase (ROCK), are implicated in a variety of cellular functions (e.g., cell adhesion, migration) via…”
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469-P: ROCK1/AMPK Axis Regulates the Development of Diabetic Kidney Disease via Modulation of Fatty Acid Metabolism by NAGAI, YOSUKE, MATOBA, KEIICHIRO, TAKEDA, YUSUKE, AKAMINE, TOMOYO, KAWANAMI, DAIJI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase Rho and its effector Rho-kinase are involved in the pathogenesis of diabetic kidney disease. Accumulating evidence shows that renal…”
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481-P: Renal Distribution and Expression Analysis of ROCK Isoforms in Diabetic Kidney Disease by MATOBA, KEIICHIRO, TAKEDA, YUSUKE, NAGAI, YOSUKE, AKAMINE, TOMOYO, KANAZAWA, YASUSHI, KAWANAMI, DAIJI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase Rho and its effector, Rho-kinase (ROCK), are implicated in the fundamental cellular processes (e.g., cell adhesion, migration). Studies over…”
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117-OR: Inhibition of Endothelial ROCK2 Induces Fat Browning and Improves Metabolic Dysfunction by TAKEDA, YUSUKE, MATOBA, KEIICHIRO, NAGAI, YOSUKE, UKICHI, RIKAKO, SEKIGUCHI, KENSUKE, AKAMINE, TOMOYO, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…Intraperitoneal fat is regarded as an important risk factor for dyslipidemia, impaired glucose tolerance, and coronary heart diseases. However, the detailed…”
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389-P: Pathological Significance of Renal Tubular ROCK2 in Chronic Kidney Disease by SEKIGUCHI, KENSUKE, MATOBA, KEIICHIRO, UKICHI, RIKAKO, NAGAI, YOSUKE, TAKEDA, YUSUKE, AKAMINE, TOMOYO, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase Rho and its effector Rho-kinase (ROCK) are implicated in the pathogenesis of diabetic kidney disease. In chronic kidney diseases including…”
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394-P: ROCK1/AMPK Axis Regulates the Development of Diabetic Kidney Disease via Modulation of Fatty Acid Metabolism by NAGAI, YOSUKE, MATOBA, KEIICHIRO, SEKIGUCHI, KENSUKE, UKICHI, RIKAKO, TAKEDA, YUSUKE, AKAMINE, TOMOYO, KANAZAWA, YASUSHI, UTSUNOMIYA, KAZUNORI, NISHIMURA, RIMEI

“…The small GTPase Rho and its effector Rho-kinase (ROCK) are involved in the pathogenesis of diabetic kidney disease. Accumulating evidence shows that renal…”
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Establishment of a myelinating co-culture system with a motor neuron-like cell line NSC-34 and an adult rat Schwann cell line IFRS1 by Takaku, Shizuka, Yako, Hideji, Niimi, Naoko, Akamine, Tomoyo, Kawanami, Daiji, Utsunomiya, Kazunori, Sango, Kazunori

“…Co-culture models of neurons and Schwann cells have been utilized for the study of myelination and demyelination in the peripheral nervous system; in most of…”
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Rho-Kinase Induces CTGF Expression through Actin Dynamics in Mesangial Cells by NAGAI, YOSUKE, KAWANAMI, DAIJI, MATOBA, KEIICHIRO, TAKEDA, YUSUKE, AKAMINE, TOMOYO, ISHIZAWA, SHO, KANAZAWA, YASUSHI, YOKOTA, TAMOTSU, UTSUNOMIYA, KAZUNORI

“…Introduction: Transforming growth factor (TGF)-β promotes the development of diabetic nephropathy by enhancing excessive production of extracellular matrix…”
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ROCK2 Regulates the Expression of Cell Adhesion Molecules and Cell-to-Cell Adhesion in Vascular Endothelial Cells by TAKEDA, YUSUKE, MATOBA, KEIICHIRO, KAWANAMI, DAIJI, NAGAI, YOSUKE, AKAMINE, TOMOYO, ISHIZAWA, SHO, KANAZAWA, YASUSHI, YOKOTA, TAMOTSU, UTSUNOMIYA, KAZUNORI

“…A pro-inflammatory lipid mediator, lysophosphatidic acid (LPA), is a potent activator of the RhoA/Rho kinase signaling pathway and has been shown to induce the…”
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