Search Results - "Akamatsu, Yuzuru"

Novel semisynthetic antibiotics from caprazamycins A–G: caprazene derivatives and their antibacterial activity by Takahashi, Yoshiaki, Igarashi, Masayuki, Miyake, Toshiaki, Soutome, Hiromi, Ishikawa, Kanae, Komatsuki, Yasuhiro, Koyama, Yoshiko, Nakagawa, Naoko, Hattori, Seiko, Inoue, Kunio, Doi, Norio, Akamatsu, Yuzuru

“…Acidic treatment of a mixture of caprazamycins (CPZs) A–G isolated from a screen of novel antimycobacterial agents gave caprazene, a core structure of CPZs, in…”
Get full text

Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature by Hiramatsu, Keiichi, Igarashi, Masayuki, Morimoto, Yuh, Baba, Tadashi, Umekita, Maya, Akamatsu, Yuzuru

“…Abstract By screening cultures of soil bacteria, we re-discovered an old antibiotic (nybomycin) as an antibiotic with a novel feature. Nybomycin is active…”
Get full text

Reminiscence of our research on membrane phospholipids in mammalian cells by using the novel technology by AKAMATSU, Yuzuru

“…By using “our devised up-to-the-second technique” over 30 years ago, we succeeded in the first isolation in the world of the three different kinds of mammalian…”
Get full text

Isolation and Characterization of Signermycin B, an Antibiotic That Targets the Dimerization Domain of Histidine Kinase WalK by WATANABE, Takafumi, IGARASHI, Masayuki, EGUCHI, Yoko, AKAMATSU, Yuzuru, UTSUMI, Ryutaro, OKAJIMA, Toshihide, ISHII, Eiji, KINO, Hirokazu, HATANO, Masaki, SAWA, Ryuichi, UMEKITA, Maya, KIMURA, Tomoyuki, OKAMOTO, Sho

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Synthesis and antibacterial activity of tripropeptin C derivatives modified at the carboxyl groups by Hirosawa, Sehei, Takahashi, Yoshiaki, Hashizume, Hideki, Miyake, Toshiaki, Akamatsu, Yuzuru

Get full text

Synthesis and antibacterial activity of 4″ or 6″-alkanoylamino derivatives of arbekacin by Sasaki, Kazushige, Kobayashi, Yoshihiko, Kurihara, Takashi, Yamashita, Yohei, Takahashi, Yoshiaki, Miyake, Toshiaki, Akamatsu, Yuzuru

“…Arbekacin, an aminoglycoside antibiotic, is an important drug because it shows a potent efficacy against methicillin-resistant Staphylococcus aureus . However,…”
Get full text

Amycolamicin: A Novel Broad-Spectrum Antibiotic Inhibiting Bacterial Topoisomerase by Sawa, Ryuichi, Takahashi, Yoshiaki, Hashizume, Hideki, Sasaki, Kazushige, Ishizaki, Yoshimasa, Umekita, Maya, Hatano, Masaki, Abe, Hikaru, Watanabe, Takumi, Kinoshita, Naoko, Homma, Yoshiko, Hayashi, Chigusa, Inoue, Kunio, Ohba, Syunichi, Masuda, Toru, Arakawa, Masayuki, Kobayashi, Yoshihiko, Hamada, Masa, Igarashi, Masayuki, Adachi, Hayamitsu, Nishimura, Yoshio, Akamatsu, Yuzuru

“…The abuse of antibacterial drugs imposes a selection pressure on bacteria that has driven the evolution of multidrug resistance in many pathogens. Our efforts…”
Get full text

Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp by Hashizume, Hideki, Adachi, Hayamitsu, Igarashi, Masayuki, Nishimura, Yoshio, Akamatsu, Yuzuru

“…The time-kill studies using pargamicin A against Staphylococcus aureus and Enterococcus faecalis were performed. The effects of the incorporation of…”
Get full text

Structure–activity relationship of boronic acid derivatives of tyropeptin: Proteasome inhibitors by Watanabe, Takumi, Abe, Hikaru, Momose, Isao, Takahashi, Yoshikazu, Ikeda, Daishiro, Akamatsu, Yuzuru

“…The structure–activity relationship of the boronic acid derivatives of tyropeptin, a proteasome inhibitor, was studied. Among 41 derivatives,…”
Get full text

Discovery of Incednine as a Potent Modulator of the Anti-apoptotic Function of Bcl-xL from Microbial Origin by Futamura, Yushi, Sawa, Ryuichi, Umezawa, Yoji, Igarashi, Masayuki, Nakamura, Hikaru, Hasegawa, Kimiko, Yamasaki, Mikio, Tashiro, Etsu, Takahashi, Yoshikazu, Akamatsu, Yuzuru, Imoto, Masaya

“…Anti-apoptotic oncoproteins Bcl-2 and Bcl-xL are overexpressed in many cancers and play a crucial role in cancer initiation, progression, and resistance to…”
Get full text

Biosynthesis of amycolamicin: the biosynthetic origin of a branched α-aminoethyl moiety in the unusual sugar amycolose by Tohyama, Shigehiro, Takahashi, Yoshikazu, Akamatsu, Yuzuru

Get full text

Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins by Igarashi, Masayuki, Takahashi, Yoshiaki, Shitara, Tetsuo, Nakamura, Hikaru, Naganawa, Hiroshi, Miyake, Toshiaki, Akamatsu, Yuzuru

“…Novel antibiotics, active against acid-fast bacteria, caprazamycins, were isolated from the culture broth of Streptomyces sp. MK730-62F2. The planar structures…”
Get full text

Synthesis of boronic acid derivatives of tyropeptin: Proteasome inhibitors by Watanabe, Takumi, Momose, Isao, Abe, Masatoshi, Abe, Hikaru, Sawa, Ryuichi, Umezawa, Yoji, Ikeda, Daishiro, Takahashi, Yoshikazu, Akamatsu, Yuzuru

“…Synthesis of boronic acid derivatives ( 3a– c) of tyropeptin, proteasome inhibitors, are reported. Boronic acid derivatives of tyropeptin were synthesized with…”
Get full text

Vegfrecine, an Inhibitor of VEGF Receptor Tyrosine Kinases Isolated from the Culture Broth of Streptomyces sp by Nosaka, Chisato, Adachi, Hayamitsu, Sawa, Ryuichi, Nakae, Koichi, Atsumi, Sonoko, Kinoshita, Naoko, Kubota, Yumiko, Igarashi, Masayuki, Sei, Yoshihisa, Yamaguchi, Kentaro, Shibuya, Masabumi, Nishimura, Yoshio, Akamatsu, Yuzuru

“…A new inhibitor of VEGF receptor tyrosine kinases, vegfrecine (1), was isolated from the culture broth of Streptomyces sp. MK931-CF8. The molecular structure…”
Get full text

Pargamicin A, a Novel Cyclic Peptide Antibiotic from Amycolatopsis sp by Igarashi, Masayuki, Sawa, Ryuichi, Kinoshita, Naoko, Hashizume, Hideki, Nakagawa, Naoko, Homma, Yoshiko, Nishimura, Yoshio, Akamatsu, Yuzuru

“…A novel cyclic peptide antibiotic, pargamicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated ML1-hF4, was…”
Get full text

A New Type of Tripropeptin with Anteiso-branched Chain Fatty Acid from Lysobacter sp. BMK333-48F3 by Hashizume, Hideki, Igarashi, Masayuki, Sawa, Ryuichi, Adachi, Hayamitsu, Nishimura, Yoshio, Akamatsu, Yuzuru

“…Branched chain amino acids are often utilized as the precursors of many lipid-containing bacterial secondary metabolites. The effect of isoleucine on the…”
Get full text

Migrastatin Acts as a Muscarinic Acetylcholine Receptor Antagonist by Nakae, Koichi, Nishimura, Yoshio, Ohba, Syunichi, Akamatsu, Yuzuru

“…Migrastatin and its analogs have various biological activities such as inhibition of cell migration and anchorage-independent growth of cancer cells. Although…”
Get full text

Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells by Sakamoto, Shuichi, Kojima, Fukiko, Igarashi, Masayuki, Sawa, Ryuichi, Umekita, Maya, Kubota, Yumiko, Nakae, Koichi, Yamaguchi, Shoichi, Adachi, Hayamitsu, Nishimura, Yoshio, Akamatsu, Yuzuru

“…Osteoblasts are the cells responsible for bone formation during embryonic development and adult life. Small compounds that could induce osteoblast…”
Get full text

Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity by Kurata, Ikuko, Umekita, Maya, Sawa, Tsutomu, Hattori, Seiko, Hayashi, Chigusa, Kinoshita, Naoko, Homma, Yoshiko, Igarashi, Masayuki, Hamada, Masa, Watanabe, Takumi, Sawa, Ryuichi, Naganawa, Hiroshi, Takahashi, Yoshikazu, Akamatsu, Yuzuru

“…Paleic acid (1), an antibiotic, was obtained from a fermentation broth of Paenibacillus sp. BMK771-AF3. The compound is a fatty acid (9 Z ,16 R…”
Get full text

Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal root ganglion neurons by Nakae, Koichi, Kojima, Fukiko, Sawa, Ryuichi, Kubota, Yumiko, Igarashi, Masayuki, Kinoshita, Naoko, Adachi, Hayamitu, Nishimura, Yoshio, Akamatsu, Yuzuru

Get full text