Clinical efficacy of FK037 in the field of orthopedics
We carried out a multicenter collaborative trial at 15 institutes to evaluate the clinical efficacy of FK037, a new developed cephem antibiotic, in the treatment of bone and joint infections. FK037 was administered for the treatment of osteomyelitis and arthritis at 1-2g in divided doses for 6-31 da...
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| Published in: | CHEMOTHERAPY Vol. 42; no. Supplement3; pp. 317 - 327 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English Japanese |
| Published: |
Japanese Society of Chemotherapy
1994
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| Online Access: | Get full text |
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| Summary: | We carried out a multicenter collaborative trial at 15 institutes to evaluate the clinical efficacy of FK037, a new developed cephem antibiotic, in the treatment of bone and joint infections. FK037 was administered for the treatment of osteomyelitis and arthritis at 1-2g in divided doses for 6-31 days. A total of 46 patients were enrolled in the trial and the number of evaluable cases was 43. The efficacy rate for pyogenic osteomyelitis and arthritis were 68.8% and 100%, respectively. In bacteriological effect against 19 strains, the eradication rate were 68.4%(13/19). The MICs of FK037 were examined against 12 strains isolated in this clinical study. The MICs of FK037 against methicillinsusceptive Staphylococcus aureus were inferior to those of flomoxef (FMOX) and superior to those of ceftazidime (CAZ). However the MIC of FK037 against methicillin-resistant S. aureus was superior to other drugs. In Gram-negative bacteria, the MICs of FK037 were superior to those of CAZ, FMOX against Neisseria sp. and almost the same as those of CAZ against Pseudomonas aeruginosa. Two patients showed diarrhea as side effects. Five patients showed abnormal findings in clinical tests: eosinophilia evaluated in 1, GOT·GPT elevation in 3, GPT·LAP·γ-GTP elevation in 1. The results suggest that FK037 was highly useful for orthopedics infections. |
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| ISSN: | 0009-3165 1884-5894 |
| DOI: | 10.11250/chemotherapy1953.42.Supplement3_317 |