Search Results - "Akaike, Norio"

The effects of volatile anesthetics on synaptic and extrasynaptic GABA-induced neurotransmission by Kotani, Naoki, Akaike, Norio

“…Highlights ► We examined how volatile anesthetics modulate GABA release at single synaptic level. ► Each anesthetic showed different GABA-induced inhibitory…”
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The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology by Katsurabayashi, Shutaro, Oyabu, Kohei, Kubota, Kaori, Watanabe, Takuya, Nagamatsu, Tomohisa, Akaike, Norio, Iwasaki, Katsunori

“…Adenosine triphosphate (ATP) is the most vital energy source produced mainly in the mitochondria. Age-related mitochondrial dysfunction is associated with…”
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Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN by Takahashi, Nanae, Akaike, Norio, Nagamatsu, Tomohisa, Uchino, Hiroyuki, Kudo, Yoshihisa

“…We have no definitive treatment for dementia characterized by prolonged neuronal death due to the enormous accumulation of foreign matter, such as β-amyloid…”
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Depression of Synaptic N-methyl-D-Aspartate Responses by Xenon and Nitrous Oxide by Kotani, Naoki, Jang, Il-Sung, Nakamura, Michiko, Nonaka, Kiku, Nagami, Hideaki, Akaike, Norio

“…In "synapse bouton preparation" of rat hippocampal CA3 neurons, we examined how Xe and N O modulate N-methyl-D-aspartate (NMDA) receptor-mediated spontaneous…”
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Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation by Wakita, Masahito, Kotani, Naoki, Kogure, Kyuya, Akaike, Norio

“…Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated…”
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Effects of propofol on glycinergic neurotransmission in a single spinal nerve synapse preparation by Wakita, Masahito, Kotani, Naoki, Akaike, Norio

“…Abstract The effects of the intravenous anesthetic, propofol, on glycinergic transmission and on glycine receptor-mediated whole-cell currents ( IGly ) were…”
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Xenon modulates synaptic transmission to rat hippocampal CA3 neurons at both pre‐ and postsynaptic sites by Nonaka, Kiku, Kotani, Naoki, Akaike, Hironari, Shin, Min‐Chul, Yamaga, Toshitaka, Nagami, Hideaki, Akaike, Norio

“…Key points Xenon (Xe) non‐competitively inhibited whole‐cell excitatory glutamatergic current (IGlu) and whole‐cell currents gated by ionotropic glutamate…”
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Intra-axonal Ca2+ mobilization contributes to triphenyltin-induced facilitation in glycinergic transmission of rat spinal neurons by Noma, Kazuki, Kurauchi, Yuki, Katsuki, Hiroshi, Oyama, Yasuo, Akaike, Norio

“…Triphenyltin (TPT) is an organotin compound causing environmental hazard to many wild creatures. Our previous findings show that TPT increases of the frequency…”
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Modulation of excitatory synaptic transmission in rat hippocampal CA3 neurons by triphenyltin, an environmental pollutant by Wakita, Masahito, Oyama, Yasuo, Takase, Yuko, Akaike, Norio

“…•Adverse effects of triphenyltin are still a significant concern.•Triphenyltin facilitated glutamatergic synaptic transmission of neurons in the brain.•This…”
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Effects of propofol on GABAergic and glutamatergic transmission in isolated hippocampal single nerve-synapse preparations by Wakita, Masahito, Kotani, Naoki, Nonaka, Kiku, Shin, Min-Chul, Akaike, Norio

“…We evaluated the effects of propofol on synaptic transmission using a mechanically dissociated preparation of rat hippocampal CA3 neurons to allow assays of…”
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Nitrous oxide directly inhibits action potential-dependent neurotransmission from single presynaptic boutons adhering to rat hippocampal CA3 neurons by Wakita, Masahito, Kotani, Naoki, Yamaga, Toshitaka, Akaike, Norio

“…Highlights • Effect of N2 O on GABAergic and glutamatergic synapses was examined in CA3 neurons. • N2 O inhibited the AMPA/KA- and NMDA receptor-mediated…”
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Calcium channel subtypes on glutamatergic mossy fiber terminals synapsing onto rat hippocampal CA3 neurons by Shin, Min-Chul, Nonaka, Kiku, Yamaga, Toshitaka, Wakita, Masahito, Akaike, Hironari, Akaike, Norio

“…The current electrophysiological study investigated the functional roles of high- and low-voltage-activated Ca channel subtypes on glutamatergic small mossy…”
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Transsynaptic inhibition of spinal transmission by A2 botulinum toxin by Akaike, Norio, Shin, Min‐Chul, Wakita, Masahito, Torii, Yasushi, Harakawa, Tetsuhiro, Ginnaga, Akihiro, Kato, Keiko, Kaji, Ryuji, Kozaki, Shunji

“…Key points Botulinum toxin A (BoNT/A) blocks synaptic transmission via the cleavage of SNAP‐25. Axonal transport of BoNT/A (A1 type botulinum toxin (A1LL) and…”
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Modifications of excitatory and inhibitory transmission in rat hippocampal pyramidal neurons by acute lithium treatment by Wakita, Masahito, Nagami, Hideaki, Takase, Yuko, Nakanishi, Ryoji, Kotani, Naoki, Akaike, Norio

“…Highlights • Acute effects of Li+ were examined in isolated rat hippocampal pyramidal neurons. • 30–150 mM Li+ inhibited glutamatergic eEPSCs and GABAergic…”
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Type A1 but Not Type A2 Botulinum Toxin Decreases the Grip Strength of the Contralateral Foreleg Through Axonal Transport From the Toxin-Treated Foreleg of Rats by Torii, Yasushi, Akaike, Norio, Harakawa, Tetsuhiro, Kato, Keiko, Sugimoto, Nakaba, Goto, Yoshitaka, Nakahira, Shinji, Kohda, Tomoko, Kozaki, Shunji, Kaji, Ryuji, Ginnaga, Akihiro

“…The adverse effects of botulinum LL toxin and neurotoxin produced by subtype A1 (A1LL and A1NTX) are becoming issues, as the toxins could diffuse from the…”
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Inhibition of Membrane Na+ Channels by A Type Botulinum Toxin at Femtomolar Concentrations in Central and Peripheral Neurons by Shin, Min-Chul, Wakita, Masahito, Xie, Du-Jie, Yamaga, Toshitaka, Iwata, Satomi, Torii, Yasushi, Harakawa, Tetsuhiro, Ginnaga, Akihiro, Kozaki, Shunji, Akaike, Norio

“…Recent studies have demonstrated that the botulinum neurotoxins inhibit the release of acetylcholine, glutamate, GABA, and glycine in central nerve system…”
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AMPA-Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia by Noda, Mami, Nakanishi, Hiroshi, Nabekura, Junichi, Akaike, Norio

“…Microglial cells were isolated from rat cerebral cortex, and kainate (KA)-induced inward current was measured at a holding potential of -40 or -60 mV…”
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Techniques: Applications of the nerve–bouton preparation in neuropharmacology by Akaike, Norio, Moorhouse, Andrew J.

“…Single mammalian neurons can be isolated with adherent functional synaptic terminals using an enzyme-free, mechanical dissociation procedure. This allows…”
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Spinal Central Effects of Peripherally Applied Botulinum Neurotoxin A in Comparison between Its Subtypes A1 and A2 by Koizumi, Hidetaka, Goto, Satoshi, Okita, Shinya, Morigaki, Ryoma, Akaike, Norio, Torii, Yasushi, Harakawa, Tetsuhiro, Ginnaga, Akihiro, Kaji, Ryuji

“…Because of its unique ability to exert long-lasting synaptic transmission blockade, botulinum neurotoxin A (BoNT/A) is used to treat a wide variety of…”
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Increase in intracellular Ca2+ level by phenylsulfamide fungicides, tolylfluanid and dichlofluanid, in rat thymic lymphocytes by Fukunaga, Eri, Enma, Kana, Saitoh, Shohei, Nishimura-Danjyobara, Yumiko, Oyama, Yasuo, Akaike, Norio

“…Highlights • Tolylfluanid and dichlofluanid are frequently detected pesticides in crops. • Both pesticides increased intracellular Ca2+ levels in murine…”
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