Search Results - "Akahoshi, Tomohiro"

Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C12:02, a Protective Allele, Using an Immunopeptidomics Approach by Chikata, Takayuki, Paes, Wayne, Akahoshi, Tomohiro, Partridge, Thomas, Murakoshi, Hayato, Gatanaga, Hiroyuki, Ternette, Nicola, Oka, Shinichi, Borrow, Persephone, Takiguchi, Masafumi

“…Despite the fact that the cell surface expression level of HLA-C on both uninfected and HIV-infected cells is lower than those of HLA-A and -B, increasing…”
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CD8 + T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication by Murakoshi, Hayato, Zou, Chengcheng, Kuse, Nozomi, Akahoshi, Tomohiro, Chikata, Takayuki, Gatanaga, Hiroyuki, Oka, Shinichi, Hanke, Tomáš, Takiguchi, Masafumi

“…Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention…”
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Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines by Borthwick, Nicola, Lin, Zhansong, Akahoshi, Tomohiro, Llano, Anuska, Silva-Arrieta, Sandra, Ahmed, Tina, Dorrell, Lucy, Brander, Christian, Murakoshi, Hayato, Takiguchi, Masafumi, Hanke, Tomáš

“…Fine definition of targeted CD8+ T-cell epitopes and their human leucocyte antigen (HLA) class I restriction informs iterative improvements of HIV-1 T-cell…”
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T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics by Akahoshi, Tomohiro, Gatanaga, Hiroyuki, Kuse, Nozomi, Chikata, Takayuki, Koyanagi, Madoka, Ishizuka, Naoki, Brumme, Chanson J, Murakoshi, Hayato, Brumme, Zabrina L, Oka, Shinichi, Takiguchi, Masafumi

“…HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics…”
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Expression and surface display of Cellulomonas endoglucanase in the ethanologenic bacterium Zymobacter palmae by Kojima, Motoki, Akahoshi, Tomohiro, Okamoto, Kenji, Yanase, Hideshi

“…In order to reduce the cost of bioethanol production from lignocellulosic biomass, we developed a tool for cell surface display of cellulolytic enzymes on the…”
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Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation by Sun, Xiaoming, Shi, Yi, Akahoshi, Tomohiro, Fujiwara, Mamoru, Gatanaga, Hiroyuki, Schönbach, Christian, Kuse, Nozomi, Appay, Victor, Gao, George F., Oka, Shinichi, Takiguchi, Masafumi

“…The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses…”
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Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes by AKAHOSHI, Tomohiro, CHIKATA, Takayuki, TAMURA, Yoshiko, GATANAGA, Hiroyuki, OKA, Shinichi, TAKIGUCHI, Masafumi

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Distinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope Specificity by Yagita, Yuichi, Kuse, Nozomi, Kuroki, Kimiko, Gatanaga, Hiroyuki, Carlson, Jonathan M, Chikata, Takayuki, Brumme, Zabrina L, Murakoshi, Hayato, Akahoshi, Tomohiro, Pfeifer, Nico, Mallal, Simon, John, Mina, Ose, Toyoyuki, Matsubara, Haruki, Kanda, Ryo, Fukunaga, Yuko, Honda, Kazutaka, Kawashima, Yuka, Ariumi, Yasuo, Oka, Shinichi, Maenaka, Katsumi, Takiguchi, Masafumi

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Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B5101 by Kawashima, Yuka, Kuse, Nozomi, Gatanaga, Hiroyuki, Naruto, Takuya, Fujiwara, Mamoru, Dohki, Sachi, Akahoshi, Tomohiro, Maenaka, Katsumi, Goulder, Philip, Oka, Shinichi, Takiguchi, Masafumi

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Impact of a single HLA-A24:02-associated escape mutation on the detrimental effect of HLA-B35:01 in HIV-1 control by Murakoshi, Hayato, Koyanagi, Madoka, Akahoshi, Tomohiro, Chikata, Takayuki, Kuse, Nozomi, Gatanaga, Hiroyuki, Rowland-Jones, Sarah L., Oka, Shinichi, Takiguchi, Masafumi

“…HLA-B*35 is an HLA allele associated with rapid progression to AIDS. However, a mechanism underlying the detrimental effect of HLA-B*35 on disease outcome…”
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CTL recognition of HIV‐1‐infected cells via cross‐recognition of multiple overlapping peptides from a single 11‐mer Pol sequence by Hashimoto, Masao, Akahoshi, Tomohiro, Murakoshi, Hayato, Ishizuka, Naoki, Oka, Shinichi, Takiguchi, Masafumi

“…It is known that overlapping HIV‐1 peptides of different lengths can be presented by a given HLA class I molecule. However, the role of those peptides in CD8+…”
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HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C∗12:02/C∗14:03 by Lin, Zhansong, Kuroki, Kimiko, Kuse, Nozomi, Sun, Xiaoming, Akahoshi, Tomohiro, Qi, Ying, Chikata, Takayuki, Naruto, Takuya, Koyanagi, Madoka, Murakoshi, Hayato, Gatanaga, Hiroyuki, Oka, Shinichi, Carrington, Mary, Maenaka, Katsumi, Takiguchi, Masafumi

“…Natural killer (NK) cells control viral infection in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their human…”
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Specificity of CD8 + T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya by Mohamed, Yehia S, Borthwick, Nicola J, Moyo, Nathifa, Murakoshi, Hayato, Akahoshi, Tomohiro, Siliquini, Francesca, Hannoun, Zara, Crook, Alison, Hayes, Peter, Fast, Patricia E, Mutua, Gaudensia, Jaoko, Walter, Silva-Arrieta, Sandra, Llano, Anuska, Brander, Christian, Takiguchi, Masafumi, Hanke, Tomáš

“…Sub-Saharan Africa carries the biggest burden of the human immunodeficiency virus type 1 (HIV-1)/AIDS epidemic and is in an urgent need of an effective…”
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Identification and characterization of HLA-B5401-restricted HIV-1-Nef and Pol-specific CTL epitopes by Kitano, Mitsutaka, Kobayashi, Naoki, Kawashima, Yuka, Akahoshi, Tomohiro, Nokihara, Kiyoshi, Oka, Shinichi, Takighuchi, Masafumi

“…The identification of HIV-1 cytotoxic T lymphocyte (CTL) epitopes presented by each HLA allele and the characterization of their CTL responses are important…”
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STING Ligand-Mediated Priming of Functional CD8 + T Cells Specific for HIV-1-Protective Epitopes from Naive T Cells by Kuse, Nozomi, Akahoshi, Tomohiro, Takiguchi, Masafumi

“…Functional HIV-1-specific CD8 T cells primed from naive T cells are expected to act as effector T cells in a "shock-and-kill" therapeutic strategy for an HIV-1…”
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Identification and characterization of 2 HIV-1 Gag immunodominant epitopes restricted by Asian HLA allele HLA-B4801 by Murakoshi, Hayato, Kitano, Mitsutaka, Akahoshi, Tomohiro, Kawashima, Yuka, Dohki, Sachi, Oka, Shinichi, Takiguchi, Masafumi

“…Abstract HLA-B*4801 is frequently found in Asian populations but rarely in Caucasian or African populations. Although HLA-B*4801–restricted human…”
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Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens by Zou, Chengcheng, Murakoshi, Hayato, Kuse, Nozomi, Akahoshi, Tomohiro, Chikata, Takayuki, Gatanaga, Hiroyuki, Oka, Shinichi, Hanke, Tomáš, Takiguchi, Masafumi

“…Cytotoxic T lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and recognize circulating HIV-1 could be key for both HIV-1 cure and…”
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Role of Escape Mutant-Specific T Cells in Suppression of HIV-1 Replication and Coevolution with HIV-1 by Zhang, Yu, Kuse, Nozomi, Akahoshi, Tomohiro, Chikata, Takayuki, Gatanaga, Hiroyuki, Oka, Shinichi, Murakoshi, Hayato, Takiguchi, Masafumi

“…The accumulation of HIV-1 escape mutations affects HIV-1 control by HIV-1-specific T cells. Some of these mutations can elicit escape mutant-specific T cells,…”
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Collaboration of a Detrimental HLA-B35:01 Allele with HLA-A24:02 in Coevolution of HIV-1 with T Cells Leading to Poorer Clinical Outcomes by Kuse, Nozomi, Murakoshi, Hayato, Akahoshi, Tomohiro, Chikata, Takayuki, James, Katherine L, Gatanaga, Hiroyuki, Rowland-Jones, Sarah L, Oka, Shinichi, Takiguchi, Masafumi

“…Although mutant-specific T cells are elicited in some individuals infected with HIV-1 mutant viruses, the detailed characteristics of these T cells remain…”
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Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes by Murakoshi, Hayato, Akahoshi, Tomohiro, Koyanagi, Madoka, Chikata, Takayuki, Naruto, Takuya, Maruyama, Rie, Tamura, Yoshiko, Ishizuka, Naoki, Gatanaga, Hiroyuki, Oka, Shinichi, Takiguchi, Masafumi

“…Identification and characterization of CD8(+) T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies…”
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