Search Results - "Akaho, Eiichi"

Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors by Zheng, Xiaoxia, Oda, Hiroyuki, Takamatsu, Kayo, Sugimoto, Yukio, Tai, Akihiro, Akaho, Eiichi, Ali, Hamed Ismail, Oshiki, Toshiyuki, Kakuta, Hiroki, Sasaki, Kenji

“…Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1 inhibitors as analgesic agents are reported. In order to create novel…”
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An innovative classification of, and a new structure-activity-relationship approach to degradation kinetics of cephalosporins: an attempt to enhance the therapeutic activity by Akaho, Eiichi, Nakayama, Hitomi

“…Degradation kinetics of cephalosporins was innovatively classified into six groups according to its mechanism that is based on the attached functional and/or…”
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Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11 by Ali, Hamed I., Yamada, Morio, Fujita, Yukihisa, Maeda, Mitsuko, Akaho, Eiichi

“…We investigated the 16α-hydroxylation of steroid molecules and regioselective binding mode in homology-modeled cytochrome P450-2C11 to correlate the biological…”
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A Study on the Interaction between p60c-Src Receptor Tyrosine Kinase and Arylcarboxylic and Arylacetic Acid Derivatives Based on Docking Modes and in Vitro Activity by Altuntas, Tunca Gul, Olgen, Sureyya, Nebioglu, Dogu, Akaho, Eiichi

“…The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the…”
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A comparative study of internet search engines by applying cost effective treatment for myocardial infarction as a search topic by AKAHO, E, SYED RIZWANUDDIN AHMAD

“…Reports results of a comparative study of Internet search engines by means of searches for a specific search topic: 'cost effective treatment for myocardial…”
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A comparative study of AutoDock and PMF scoring performances, and SAR of 2-substituted pyrazolotriazolopyrimidines and 4-substituted pyrazolopyrimidines as potent xanthine oxidase inhibitors by Ali, Hamed I., Fujita, Takayuki, Akaho, Eiichi, Nagamatsu, Tomohisa

“…4-Alkylidenehydrazino-1H-pyrazolo[3,4-d]pyrimidines, 4-arylmethylidenehydrazino-1H-pyrazolo[3,4-d]pyrimidines, and 2-substituted…”
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A Proposed Optimal Health Care System Based on a Comparative Study Conducted Between Canada and Japan by Akaho, Eiichi, Coffin, Garth D., Kusano, Takanori, Locke, Linda, Okamoto, Takashi

“…Objectives: Every country wants a good health care system for all citizens with minimum expenditure. By comparing health care systems in Canada and Japan, both…”
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American and Japanese drug distribution and information systems in 1994 and a proposed system for improved pharmaceutical care by AKAHO, E, RUNION, H. I, INOUE, K

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A study of pharmacists' consciousness toward separation of medical practice from pharmaceutical dispensing by Akaho, Eiichi, Uchinashi, Masako, Tsurusawa, Akiko, Tominaga, Junko, Hayashi, Shinichi

“…Separation of medical practice from pharmaceutical dispensing had been a system with just the notation without the reality even after Showa era, although its…”
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Antitumor studies – Part 2: Structure–activity relationship study for flavin analogs including investigations on their in vitro antitumor assay and docking simulation into protein tyrosine kinase by Ali, Hamed I., Tomita, Keiichiro, Akaho, Eiichi, Kunishima, Munetaka, Kawashima, Yutaka, Yamagishi, Takehiro, Ikeya, Hisao, Nagamatsu, Tomohisa

“…Various analogs of flavins, 5-deazaflavins, and flavin-5-oxides were docked into the binding site of protein tyrosine kinase pp60 c-src, and some of them were…”
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Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents by Ali, Hamed I., Tomita, Keiichiro, Akaho, Eiichi, Kambara, Hiroto, Miura, Shinji, Hayakawa, Hiroyuki, Ashida, Noriyuki, Kawashima, Yutaka, Yamagishi, Takehiro, Ikeya, Hisao, Yoneda, Fumio, Nagamatsu, Tomohisa

“…The prepared 2-deoxo-2-phenyl-5-deazaflavins ( 1) and 2-deoxo-2-phenylflavin-5-oxides ( 2) exhibited significant antitumor activities against CCRF-HSB-2, KB,…”
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Effect of Additives on Physical Properties of Fine Ethyl Cellulose Microcapsules Prepared by the Wurster Process by FUKUMORI, Yoshinobu, ICHIKAWA, Hideki, YAMAOKA, Yumiko, AKAHO, Eiichi, TAKEUCHI, Yoshikazu, FUKUDA, Tomoaki, KANAMORI, Ryuichi, OSAKO, Yoshifumi

“…Ethyl cellulose (EC) microcapsules with fine calcium carbonate cores (32-44μm) and drug layers were prepared. The effect of additives on the particle size…”
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VSDK: Virtual screening of small molecules using AutoDock Vina on Windows platform by Baba, Natsumi, Akaho, Eiichi

“…Screening of ligand molecules to target proteins using computer-aided docking is a critical step in rational drug discovery. Based on this circumstance, we…”
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Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors by Ali, Hamed Ismail, Nagamatsu, Tomofumi, Akaho, Eiichi

“…Different classes of compounds were investigated for their binding affinities into different protein tyrosine kinases (PTKs) employing a novel flexible ligand…”
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薬剤師の医薬分業に対する意識に関する調査 by 赤穗, 榮一, 内梨, 雅子, 鶴澤, 明子, 冨永, 順子, 林, 信一

“…医師法第22条や薬剤師法第19条に記されているように, 本来診断及び処方は医師が, 調剤は薬剤師が行うとされている. この医薬分業12)は単なる役割分担ではなく, 医師薬剤師が自己の権利と義務を認識し責任を持つことで更なる医療の発展を目指したものである. しかし,…”
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Reduction of Lipophilicity at the Lipophilic Domain of RXR Agonists Enables Production of Subtype Preference: RXRα-Preferential Agonist Possessing a Sulfonamide Moiety by Takamatsu, Kayo, Takano, Atsushi, Yakushiji, Nobumasa, Morishita, Ken-ichi, Matsuura, Nobuyasu, Makishima, Makoto, Ali, Hamed Ismail, Akaho, Eiichi, Tai, Akihiro, Sasaki, Kenji, Kakuta, Hiroki

“…Retinoid X receptor agonists (RXR agonists, rexinoids) are interesting candidates for the treatment of cancers such as tamoxifen‐resistant breast cancer and…”
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Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors by Olgen, Sureyya, Akaho, Eiichi, Nebioglu, Dogu

“…A series of N-substituted indole-2-carboxylic acid esters have been prepared by replacing the benzoyl group of indomethacin with a benzyl and a phenyl group…”
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Evaluation of indole esters as inhibitors of p60(c-Src) receptor tyrosine kinase and investigation of the inhibition using receptor docking studies by Olgen, Sureyya, Akaho, Eiichi, Nebioglu, Dogu

“…Several indole esters were tested as inhibitors of tyrosine kinase p60(c-Src). Compound (4) was found fairly active against the enzyme with IC50 = 1.34 microM…”
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Studies on adsorption characteristics and mechanism of adsorption of chlorhexidine mainly by carbon black by Akaho, E, Fukumori, Y

“…The extent of adsorption of chlorhexidine to carbon black and sanitary cotton was determined by measuring the amounts of chlorhexidine adsorbed to carbon black…”
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Corrigendum to “Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors” [Bioorg. Med. Chem. 15 (2007) 1014–1021] by Zheng, Xiaoxia, Oda, Hiroyuki, Takamatsu, Kayo, Sugimoto, Yukio, Tai, Akihiro, Akaho, Eiichi, Ali, Hamed Ismail, Oshiki, Toshiyuki, Kakuta, Hiroki, Sasaki, Kenji

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