Search Results - "Akahane, Toshiaki"

A tailored next‐generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomas by Higa, Nayuta, Akahane, Toshiaki, Yokoyama, Seiya, Yonezawa, Hajime, Uchida, Hiroyuki, Takajo, Tomoko, Kirishima, Mari, Hamada, Taiji, Matsuo, Kei, Fujio, Shingo, Hanada, Tomoko, Hosoyama, Hiroshi, Yonenaga, Masanori, Sakamoto, Akihisa, Hiraki, Tsubasa, Tanimoto, Akihide, Yoshimoto, Koji

“…Central nervous system tumors are classified based on an integrated diagnosis combining histology and molecular characteristics, including IDH1/2 and H3‐K27M…”
Get full text

Genome Editing Using Cas9 Ribonucleoprotein Is Effective for Introducing PDGFRA Variant in Cultured Human Glioblastoma Cell Lines by Hamada, Taiji, Yokoyama, Seiya, Akahane, Toshiaki, Matsuo, Kei, Tanimoto, Akihide

“…Many variants of uncertain significance (VUS) have been detected in clinical cancer cases using next-generation sequencing-based cancer gene panel analysis…”
Get full text

An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors by Hamada, Taiji, Akahane, Toshiaki, Yokoyama, Seiya, Higa, Nayuta, Kirishima, Mari, Matsuo, Kei, Shimokawa, Michiko, Yoshimoto, Koji, Tanimoto, Akihide

“…Understanding human genome alterations is necessary to optimize genome-based cancer therapeutics. However, some newly discovered mutations remain as variants…”
Get full text

Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel by HIGA, Nayuta, AKAHANE, Toshiaki, YOKOYAMA, Seiya, YONEZAWA, Hajime, UCHIDA, Hiroyuki, FUJIO, Shingo, KIRISHIMA, Mari, TAKIGAWA, Kosuke, HATA, Nobuhiro, TOH, Keita, YAMAMOTO, Junkoh, HANAYA, Ryosuke, TANIMOTO, Akihide, YOSHIMOTO, Koji

“…Rapid technological advances in molecular biology, including next-generation sequencing, have identified key genetic alterations in central nervous system…”
Get full text

PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells by Kitazono, Ikumi, Hamada, Taiji, Yoshimura, Takuya, Kirishima, Mari, Yokoyama, Seiya, Akahane, Toshiaki, Tanimoto, Akihide

“…Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is 7.6 kDa peptide originally found in Purkinje cells. PCP4/PEP19 is a differentiation maker of Purkinje cells,…”
Get full text

Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions by Akahane, Toshiaki, Kanomata, Naoki, Harada, Oi, Yamashita, Tetsumasa, Kurebayashi, Junichi, Tanimoto, Akihide, Moriya, Takuya

“…Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor…”
Get full text

MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer by Hamada, Taiji, Higashi, Michiyo, Yokoyama, Seiya, Akahane, Toshiaki, Hisaoka, Masanori, Noguchi, Hirotsugu, Furukawa, Tatsuhiko, Tanimoto, Akihide

“…The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with…”
Get full text

Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis by Akahane, Toshiaki, Yamaguchi, Tomomi, Kato, Yasutaka, Yokoyama, Seiya, Hamada, Taiji, Nishida, Yukari, Higashi, Michiyo, Nishihara, Hiroshi, Suzuki, Shinsuke, Ueno, Shinichi, Tanimoto, Akihide

“…In addition to conventional cytology, liquid-based cytology (LBC) is also used for immunocytochemistry and gene analysis. However, an appropriate method to…”
Get full text

Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma by Kirishima, Mari, Yokoyama, Seiya, Akahane, Toshiaki, Higa, Nayuta, Uchida, Hiroyuki, Yonezawa, Hajime, Matsuo, Kei, Yamamoto, Junkoh, Yoshimoto, Koji, Hanaya, Ryosuke, Tanimoto, Akihide

“…Glioblastomas (GBMs) are the most aggressive types of central nervous system tumors. Although certain genomic alterations have been identified as prognostic…”
Get full text

Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid by Yoshida, Michiharu, Kobayashi, Hiroyuki, Terasaka, Shunsuke, Endo, Shogo, Yamaguchi, Shigeru, Motegi, Hiroaki, Itay, Rachmilevitch, Suzuki, Shuji, Brokman, Omer, Shapira, Yeruham, Moriyama, Kenji, Kawase, Yumiko, Akahane, Toshiaki, Kato, Yasutaka, Kamada, Hajime, Houkin, Kiyohiro

“…Sonodynamic therapy (SDT) is used to treat various malignancies and can be applied to brain tumors using a transcranial magnetic resonance imaging-guided…”
Get full text

Sequential evaluation of MUC promoter methylation using next‐generation sequencing‐based custom‐made panels in liquid‐based cytology specimens of pancreatic cancer by Yokoyama, Sieya, Iwaya, Hiromichi, Akahane, Toshiaki, Hamada, Taiji, Higashi, Michiyo, Hashimoto, Shinichi, Tanoue, Shiroh, Ohtsuka, Takao, Ido, Akio, Tanimoto, Akihide

“…Background As liquid‐based cytology (LBC) specimens preserve high‐quality DNA, clinical sequencing of LBC specimens using next‐generation sequencing (NGS) is…”
Get full text

Gallbladder microbiota composition is associated with pancreaticobiliary and gallbladder cancer prognosis by Kirishima, Mari, Yokoyama, Seiya, Matsuo, Kei, Hamada, Taiji, Shimokawa, Michiko, Akahane, Toshiaki, Sugimoto, Tomoyuki, Tsurumaru, Hirohito, Ishibashi, Matsujiro, Mataki, Yuko, Ootsuka, Takao, Nomoto, Mitsuharu, Hayashi, Chihiro, Horiguchi, Akihiko, Higashi, Michiyo, Tanimoto, Akihide

“…The microbial population of the intestinal tract and its relationship to specific diseases has been extensively studied during the past decade. However,…”
Get full text

Direct next‐generation sequencing analysis using endometrial liquid‐based cytology specimens for rapid cancer genomic profiling by Akahane, Toshiaki, Kitazono, Ikumi, Kobayashi, Yusuke, Nishida‐Kirita, Yukari, Yamaguchi, Tomomi, Yanazume, Shintaro, Tabata, Kazuhiro, Kobayashi, Hiroaki, Tanimoto, Akihide

“…Background Genomic examination of cytology specimens is often performed on cell blocks or conventional smears rather than on liquid‐based cytology (LBC)…”
Get full text

Human Papilloma Virus 18-Positive Submucosal Small Cell Neuroendocrine Carcinoma of the Vagina: An Immunohistochemical and Genomic Study by Kitazono, Ikumi, Akahane, Toshiaki, Sakihama, Mika, Yanazume, Shintaro, Matsushita, Michiko, Tabata, Kazuhiro, Kobayashi, Yusuke, Kobayashi, Hiroaki, Umekita, Yoshihisa, Tanimoto, Akihide

“…Primary vaginal neuroendocrine carcinoma (NEC) is extremely rare among female genital tract tumors. Here, we report 2 cases of vaginal small cell NEC (SCNEC)…”
Get full text

Next‐generation sequencing in residual liquid‐based cytology specimens for cancer genome analysis by Yamaguchi, Tomomi, Akahane, Toshiaki, Harada, Ohi, Kato, Yasutaka, Aimono, Eriko, Takei, Hidehiro, Tasaki, Takashi, Noguchi, Hirotsugu, Nishihara, Hiroshi, Kamata, Hajime, Tanimoto, Akihide

“…Background Cancer genome profiling of cytology specimens using next‐generation sequencing (NGS) requires adequate and good‐quality DNA. Genomic examination of…”
Get full text

Integrated diagnosis of adult‐type glioma according to 2021 World Health Organization classification: Analysis of 184 cases using a custom‐made next‐generation sequencing panel by Kirishima, Mari, Akahane, Toshiaki, Higa, Nayuta, Yonezawa, Hajime, Uchida, Hiroyuki, Kitazono, Ikumi, Higashi, Michiyo, Yoshimoto, Koji, Tanimoto, Akihide

Get full text

Molecular Evaluation of Endometrial Dedifferentiated Carcinoma, Endometrioid Carcinoma, Carcinosarcoma, and Serous Carcinoma Using a Custom-Made Small Cancer Panel by Kobayashi, Yusuke, Kitazono, Ikumi, Akahane, Toshiaki, Yanazume, Shintaro, Kamio, Masaki, Togami, Shinichi, Nohara, Sachio, Sakamoto, Ippei, Yokoyama, Seiya, Tabata, Kazuhiro, Kobayashi, Hiroaki, Tanimoto, Akihide

“…It is often difficult to histologically differentiate among endometrial dedifferentiated carcinoma (DC), endometrioid carcinoma (EC), serous carcinoma (SC),…”
Get full text

Next-generation sequencing analysis of endometrial screening liquid-based cytology specimens: a comparative study to tissue specimens by Akahane, Toshiaki, Kitazono, Ikumi, Yanazume, Shintaro, Kamio, Masaki, Togami, Shinichi, Sakamoto, Ippei, Nohara, Sachio, Yokoyama, Seiya, Kobayashi, Hiroaki, Hiraki, Tsubasa, Suzuki, Shinsuke, Ueno, Shinichi, Tanimoto, Akihide

“…Liquid-based cytology (LBC) is now a widely used method for cytologic screening and cancer diagnosis. Since the cells are fixed with alcohol-based fixatives,…”
Get full text

The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses by Kanai, Yae, Nishihara, Hiroshi, Miyagi, Yohei, Tsuruyama, Tatsuhiro, Taguchi, Kenichi, Katoh, Hiroto, Takeuchi, Tomoyo, Gotoh, Masahiro, Kuramoto, Junko, Arai, Eri, Ojima, Hidenori, Shibuya, Ayako, Yoshida, Teruhiko, Akahane, Toshiaki, Kasajima, Rika, Morita, Kei‐ichi, Inazawa, Johji, Sasaki, Takeshi, Fukayama, Masashi, Oda, Yoshinao

“…Genome research using appropriately collected pathological tissue samples is expected to yield breakthroughs in the development of biomarkers and…”
Get full text

Two Components of Variant Profiles in Primary Vaginal Carcinosarcoma via Next-Generation Sequencing and a Literature Review by Kotoku, Rakan, Yanazume, Shintaro, Kuroda, Takafumi, Kobayashi, Yusuke, Kitazono, Ikumi, Akahane, Toshiaki, Tanimoto, Akihide, Kobayashi, Hiroaki

“…Primary vaginal carcinosarcoma (VCS) is an extremely rare and aggressive tumor consisting of admixed malignant epithelial and mesenchymal elements. We report a…”
Get full text