WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer

The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we p...

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Bibliographic Details
Published in:	Environment international Vol. 126; pp. 804 - 815
Main Authors:	Paulo, Marilia Silva, Adam, Balazs, Akagwu, Cyril, Akparibo, Issaka, Al-Rifai, Rami H., Bazrafshan, Sholeh, Gobba, Fabriziomaria, Green, Adele C., Ivanov, Ivan, Kezic, Sanja, Leppink, Nancy, Loney, Tom, Modenese, Alberto, Pega, Frank, Peters, Cheryl E., Prüss-Üstün, Annette M., Tenkate, Thomas, Ujita, Yuka, Wittlich, Marc, John, Swen M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-05-2019 Elsevier
Subjects:	Cost of Illness Cross-Sectional Studies Humans Melanoma - etiology Meta-Analysis as Topic Occupational Diseases - etiology Occupational Exposure - analysis Quality-Adjusted Life Years Skin Neoplasms - etiology Systematic Reviews as Topic Ultraviolet Rays - adverse effects World Health Organization
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Summary:	The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from melanoma and non-melanoma skin cancer (or keratinocyte carcinoma) from occupational exposure to solar ultraviolet radiation, to inform the development of the WHO/ILO joint methodology. We aim to systematically review studies on occupational exposure to solar ultraviolet radiation (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework and conducting both systematic reviews in tandem and in a harmonized way. Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Ovid Medline, PubMed, EMBASE, and Web of Science. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand-search reference list of previous systematic reviews and included study records and consult additional experts. We will include working-age (≥15 years) workers in the formal and informal economy in any WHO and/or ILO Member State, but exclude children (<15 years) and unpaid domestic workers. For Systematic Review 1, we will include quantitative studies on the prevalence of relevant levels of occupational exposure to solar ultraviolet radiation (i.e. <0.33 SED/d and ≥0.33 SED/d) and of the total working time spent outdoors, stratified by country, sex, age and industrial sector or occupation, in the years 1960 to 2018. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the effect of any occupational exposure to solar ultraviolet radiation (i.e., ≥0.33 SED/d) on the prevalence of, incidence of or mortality due to melanoma and non-melanoma skin cancer, compared with the theoretical minimum risk exposure level (i.e. <0.33 SED/d). At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess the risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2. CRD42018094817. •WHO and ILO are developing a joint methodology for estimating the national and global work-related burden of disease and injury.•A large network of experts is contributing to this WHO/ILO joint methodology with two systematic reviews described in this protocol.•The authors will systematically review studies on occupational exposure to solar ultraviolet radiation (Systematic Review 1).•They will also systematically review and meta-analyse estimates of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer (Systematic Review 2).•The authors will develop both systematic reviews in tandem and in a harmonized way, using the Navigation Guide systematic review methodology as an organizing framework.
ISSN:	0160-4120 1873-6750
DOI:	10.1016/j.envint.2018.09.039