Search Results - "Akagi, Kazutaka"
-
1
Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila
Published in Scientific reports (05-11-2020)“…Exposure to genotoxic stress by environmental agents or treatments, such as radiation therapy, can diminish healthspan and accelerate aging. We have developed…”
Get full text
Journal Article -
2
Proteasome activity determines pupation timing through the degradation speed of timer molecule Blimp‐1
Published in Development, growth & differentiation (01-10-2018)“…The transcriptional repressor Blimp‐1 is a labile protein. This characteristic is key for determining pupation timing because the timing of the disappearance…”
Get full text
Journal Article -
3
Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster
Published in PLoS genetics (01-11-2018)“…Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function…”
Get full text
Journal Article -
4
Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2015)“…Significance Metamorphosis is an important biological process by which animals alter their body structures to become sexually mature adults. We discovered that…”
Get full text
Journal Article -
5
New Possibilities for Evaluating the Development of Age-Related Pathologies Using the Dynamical Network Biomarkers Theory
Published in Cells (Basel, Switzerland) (01-09-2023)“…Aging is the slowest process in a living organism. During this process, mortality rate increases exponentially due to the accumulation of damage at the…”
Get full text
Journal Article -
6
The binding of multiple nuclear receptors to a single regulatory region is important for the proper expression of EDG84A in Drosophila melanogaster
Published in Journal of molecular biology (09-01-2013)“…Nuclear receptor transcription factor family members share target sequence similarity; however, little is known about how these factors exert their specific…”
Get full text
Journal Article -
7
Drosophila Blimp-1 Is a Transient Transcriptional Repressor That Controls Timing of the Ecdysone-Induced Developmental Pathway
Published in Molecular and Cellular Biology (01-12-2007)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
8
2B-02 Control mechanism of prepupal period in different Drosophila species
Published in Genes & Genetic Systems (2010)“…Living organisms somehow determine developmental timing in their life. Intriguingly, in Drosophila melanogaster, the prepupal period is 12 hours at standard…”
Get full text
Journal Article -
9
General sessions1B-08 Transcriptional repressor Blimp-1 works as an hourglass in the biological timer system to determine pupation timing in Drosophila
Published in Genes & Genetic Systems (2009)“…At the onset of metamorphosis in D.melanogaster, a large pulse of ecdysone causes puparium formation and this is followed by another small ecdysone pulse that…”
Get full text
Journal Article -
10
2C-09 Determination mechanism of pupation timing by unstable transcription factor Blimp-1 in Drosophila
Published in Genes & Genetic Systems (2007)“…We have recently found that Blimp-1, which induced directly by ecdysone plays important roles in determining the precise timing of FTZ-F1 expression and the…”
Get full text
Journal Article -
11
Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila
Published in Cell metabolism (12-01-2016)“…Endogenous circadian clocks orchestrate several metabolic and signaling pathways that are known to modulate lifespan, suggesting clocks as potential targets…”
Get full text
Journal Article -
12
Autocrine regulation of ecdysone synthesis by beta 3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2015)“…In Drosophila, pulsed production of the steroid hormone ecdysone plays a pivotal role in developmental transitions such as metamorphosis. Ecdysone production…”
Get full text
Journal Article -
13
Regulatory mechanisms of ecdysone‐inducible Blimp‐1 encoding a transcriptional repressor that is important for the prepupal development in Drosophila
Published in Development, growth & differentiation (01-06-2011)“…Blimp‐1 is an ecdysone‐inducible transcription factor that is expressed in the early stage of the prepupal period. The timing of its disappearance determines…”
Get full text
Journal Article -
14
A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster
Published in Development (Cambridge) (01-07-2016)“…During the development of multicellular organisms, many events occur with precise timing. In Drosophila melanogaster, pupation occurs about 12 h after puparium…”
Get full text
Journal Article -
15
A biological timer in the fat body comprised of Blimp-1, βFTZ-F1 and Shade regulates pupation timing in Drosophila melanogaster
Published in Development (Cambridge) (01-01-2016)“…During the development of multicellular organisms, many events occur with precise timing. In Drosophila melanogaster, pupation occurs about 12 hours after…”
Get full text
Journal Article -
16
-
17
Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential forDrosophilametamorphosis
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2015)“…InDrosophila, pulsed production of the steroid hormone ecdysone plays a pivotal role in developmental transitions such as metamorphosis. Ecdysone production is…”
Get full text
Journal Article -
18
Autocrine regulation of ecdysone synthesis by [Beta]3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2015)“…In Drosophila, pulsed production of the steroid hormone ecdysone plays a pivotal role in developmental transitions such as metamorphosis. Ecdysone production…”
Get full text
Journal Article -
19
The Binding of Multiple Nuclear Receptors to a Single Regulatory Region Is Important for the Proper Expression of EDG84A in Drosophilamelanogaster
Published in Journal of molecular biology (09-01-2013)“…Nuclear receptor transcription factor family members share target sequence similarity; however, little is known about how these factors exert their specific…”
Get full text
Journal Article