Search Results - "Akagawa, S."

Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process by Tran, Dat Huu, Sugamata, Ryuichi, Hirose, Tomoyasu, Suzuki, Shoichi, Noguchi, Yoshihiko, Sugawara, Akihiro, Ito, Fuyu, Yamamoto, Tomoko, Kawachi, Shoji, Akagawa, Kiyoko S., Ōmura, Satoshi, Sunazuka, Toshiaki, Ito, Naoki, Mimaki, Masakazu, Suzuki, Kazuo

“…The pandemic influenza 2009 (A(H1N1)pdm09) virus currently causes seasonal and annual epidemic outbreaks. The widespread use of anti-influenza drugs such as…”
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Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria by Kamada, Nobuhiko, Hisamatsu, Tadakazu, Okamoto, Susumu, Sato, Toshiro, Matsuoka, Katsuyoshi, Arai, Kumiko, Nakai, Takaaki, Hasegawa, Akira, Inoue, Nagamu, Watanabe, Noriaki, Akagawa, Kiyoko S, Hibi, Toshifumi

“…Disorders in enteric bacteria recognition by intestinal macrophages (Mphi) are strongly correlated with the pathogenesis of chronic colitis; however the…”
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Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages by AKAGAWA, Kiyoko S

“…Macrophages have various functions and play a critical role in host defense and the maintenance of homeostasis. However, macrophages are heterogeneous and…”
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Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents by Sugawara, Akihiro, Sueki, Akito, Hirose, Tomoyasu, Nagai, Kenichiro, Gouda, Hiroaki, Hirono, Shuichi, Shima, Hideaki, Akagawa, Kiyoko S., Ōmura, Satoshi, Sunazuka, Toshiaki

“…▪ Herein, we report the design and synthesis of the novel 12-membered non-antibiotic macrolide (8 R,9 S)-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A…”
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Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure–activity relationships and in vivo study by Sugawara, Akihiro, Sueki, Akito, Hirose, Tomoyasu, Shima, Hideaki, Akagawa, Kiyoko S, Ōmura, Satoshi, Sunazuka, Toshiaki

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Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPβ by Komuro, Iwao, Sunazuka, Toshiaki, Akagawa, Kiyoko S, Yokota, Yasuko, Iwamoto, Aikichi, Ōmura, Satoshi

“…Macrophages (MΦs) are a major source of HIV-1 especially in patients with tuberculosis. There are MΦs that are permissive and those that restrict HIV-1…”
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Generation of CD1+RelB+ Dendritic Cells and Tartrate-Resistant Acid Phosphatase-Positive Osteoclast-Like Multinucleated Giant Cells From Human Monocytes by Akagawa, Kiyoko S., Takasuka, Naomi, Nozaki, Yuko, Komuro, Iwao, Azuma, Miyuki, Ueda, Masamichi, Naito, Makoto, Takahashi, Kiyoshi

“…We previously showed that granulocyte-macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) stimulate the…”
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IL-10 Inhibits Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Human Monocyte Survival at the Early Stage of the Culture and Inhibits the Generation of Macrophages by Hashimoto, Shin-ichi, Komuro, Iwao, Yamada, Muneo, Akagawa, Kiyoko S

“…We previously demonstrated that IL-10 alone does not stimulate growth and differentiation of human monocytes, but enhances those of monocytes stimulated with…”
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Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages by AKAGAWA, Kiyoko S., KOMURO, Iwao, KANAZAWA, Hiroko, YAMAZAKI, Toshio, MOCHIDA, Keiko, KISHI, Fumio

“…Objectives:  Macrophages (Mφs) have various functions and play a critical role in host defense and the maintenance of homeostasis. Mφs exist in every tissue in…”
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Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis by Kamada, Nobuhiko, Hisamatsu, Tadakazu, Okamoto, Susumu, Chinen, Hiroshi, Kobayashi, Taku, Sato, Toshiro, Sakuraba, Atsushi, Kitazume, Mina T, Sugita, Akira, Koganei, Kazutaka, Akagawa, Kiyoko S, Hibi, Toshifumi

“…Intestinal macrophages play a central role in regulation of immune responses against commensal bacteria. In general, intestinal macrophages lack the expression…”
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Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model by Sugawara, Akihiro, Shima, Hideaki, Sueki, Akito, Hirose, Tomoyasu, Matsui, Hidehito, Nakano, Hayato, Hanaki, Hideaki, Akagawa, Kiyoko S, Ōmura, Satoshi, Sunazuka, Toshiaki

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Expression of Th2-skewed pathology mediators in monocyte-derived type 2 of dendritic cells (DC2) by Hata, Mitsumi, Takahara, Seiji, Tsuzaki, Hidetoshi, Ishii, Yoshiki, Nakata, Koh, Akagawa, Kiyoko S, Satoh, Kazuki

“…Abstract The information conveyed from dendritic cells (DCs) to naïve CD4+ T cells has crucial influence on their differentiation toward effector T cells. In…”
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Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression by Sugamata, Ryuichi, Sugawara, Akihiro, Nagao, Tomokazu, Suzuki, Koya, Hirose, Tomoyasu, Yamamoto, Ki-ichi, Oshima, Masamichi, Kobayashi, Kazuo, Sunazuka, Toshiaki, Akagawa, Kiyoko S, Ōmura, Satoshi, Nakayama, Toshinori, Suzuki, Kazuo

“…Severe respiratory disease arising from influenza virus infection has a high fatality rate. Neutrophil myeloperoxidase (MPO) has been implicated in the…”
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Catalase Plays a Critical Role in the CSF-independent Survival of Human Macrophages via Regulation of the Expression of BCL-2 Family by Komuro, Iwao, Yasuda, Tomoyoshi, Iwamoto, Aikichi, Akagawa, Kiyoko S.

“…M-colony-stimulating factor (M-CSF)-induced monocyte-derived macrophages (M-MΦ) required continuous presence of M-CSF for their survival, and depletion of…”
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Pancreatic cancer cells in hypoxia enhance the motility of pancreatic stellate cells via increased secretion of vascular endothelial growth factor by Eguchi, D, Ohuchida, K, Kozono, S, Cui, L, Zhao, M, Kenji, F, Akagawa, S, Ohtsuka, T, Takahata, S, Mizumoto, K, Tanaka, M

“…All pancreatic cancer cells in hypoxia expressed vascular endothelial growth factor (VEGF) at higher level compared with those in normoxia and the supernatants…”
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Role of peritoneal fibroblasts at disseminated sites of pancreatic cancer by Akagawa, S, Ohuchida, K, Ohtsuka, T, Eguchi, D, Fujiwara, K, Kozono, S, Cui, L, Ikenaga, N, Aishima, S, Mizumoto, K, Tanaka, M

“…Background: Fibroblasts existing in stroma of pancreatic cancer promote proliferation, invasion and metastasis of pancreatic cancer via increases in…”
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Enhancement of Macrophage Colony-Stimulating Factor–Induced Growth and Differentiation of Human Monocytes by Interleukin-10 by Hashimoto, Shin-ichi, Yamada, Muneo, Motoyoshi, Kazuo, Akagawa, Kiyoko S.

“…Interleukin-10 (IL-10) has been reported to be a negative cytokine for monocytes/macrophages. In the present study, we showed that IL-10 is rather a positive…”
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Macrolides with Promotive Activity of Monocyte to Macrophage Differentiation by Yoshida, Kiminari, Sunazuka, Toshiaki, Nagai, Kenichiro, Sugawara, Akihiro, Cho, Achim, Nagamitsu, Tohru, Harigaya, Yoshihiro, Otoguro, Kazuhiko, Akagawa, Kiyoko S, Omura, Satoshi

“…AbstractWe have been interested in the immunomodulatory effect, to promote differentiation of the human monocytic cell line THP-1 to macrophages of EM-A. We…”
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Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model by Sugawara, Akihiro, Shima, Hideaki, Sueki, Akito, Hirose, Tomoyasu, Matsui, Hidehito, Nakano, Hayato, Hanaki, Hideaki, Akagawa, Kiyoko S, Ōmura, Satoshi, Sunazuka, Toshiaki

“…The 14-membered macrolide erythromycin A expresses three distinct biological properties, including antibacterial activity, gastrointestinal motor-stimulating…”
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Diagnosis of Active Tuberculous Serositis by Antigen-Specific Interferon-  Response of Cavity Fluid Cells by Ariga, H., Kawabe, Y., Nagai, H., Kurashima, A., Masuda, K., Matsui, H., Tamura, A., Nagayama, N., Akagawa, S., Machida, K., Hebisawa, A., Nakajima, Y., Yotsumoto, H., Mori, T.

“…To develop a more accurate methodology for diagnosing active tuberculous pleurisy, as well as peritonitis and pericardits of tuberculous origin, we established…”
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