Search Results - "Ajjarapu, Srinivas"

HPMCAS-Based Amorphous Solid Dispersions in Clinic: A Review on Manufacturing Techniques (Hot Melt Extrusion and Spray Drying), Marketed Products and Patents by Corrie, Leander, Ajjarapu, Srinivas, Banda, Srikanth, Parvathaneni, Madhukiran, Bolla, Pradeep Kumar, Kommineni, Nagavendra

“…Today, therapeutic candidates with low solubility have become increasingly common in pharmaceutical research pipelines. Several techniques such as hot melt…”
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Melt Fusion Techniques for Solubility Enhancement: A Comparison of Hot Melt Extrusion and KinetiSol® Technologies by Ajjarapu, Srinivas, Banda, Srikanth, Basim, Pratap, Dudhipala, Narendar

“…A successful candidate for oral drug delivery needs to possess adequate solubility and dissolution rate to elicit its therapeutic action. Extensive research is…”
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Analysis of docosanol using GC/MS: Method development, validation, and application to ex vivo human skin permeation studies by Shankar, Vijay Kumar, Wang, Mei, Ajjarapu, Srinivas, Kolimi, Praveen, Avula, Bharathi, Murthy, Reena, Khan, Ikhlas, Murthy, Sathyanarayana Narasimha

“…Docosanol is the only US Food and Drug Administration (FDA) approved over-the-counter topical product for treating recurrent oral-facial herpes simplex…”
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Metronidazole crystal patterns formed during the metamorphosis of topical carbopol gels by Srinivas Ajjarapu, Kevin DeBoyace, Sandeep Sarabu, Vijay K Shankar, Srinath Rangappa, Peter L Wildfong, Narasimha Murthy

“…Metronidazole topical formulations such as gels, creams, and lotions are used in the treatment of bacterial vaginosis and inflammation lesions of rosacea…”
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Instability of therapeutic proteins — An overview of stresses, stabilization mechanisms and analytical techniques involved in lyophilized proteins by Butreddy, Arun, Janga, Karthik Yadav, Ajjarapu, Srinivas, Sarabu, Sandeep, Dudhipala, Narendar

“…Solid-state is the preferred choice for storage of protein therapeutics to improve stability and preserve the biological activity by decreasing the physical…”
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Current trends in the development of liposomes for chemotherapeutic drug delivery by Kumbham, Soniya, Ajjarapu, Srinivas, Ghosh, Balaram, Biswas, Swati

“…Published literature on cancer by health agencies and health organizations reveals increased cancer incidence year by year. The first line of cancer treatment…”
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Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics and dissolution performance by Butreddy, Arun, Sarabu, Sandeep, Almutairi, Mashan, Ajjarapu, Srinivas, Kolimi, Praveen, Bandari, Suresh, Repka, Michael A.

“…[Display omitted] Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of…”
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Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin by Shankar, Vijay Kumar, Police, Anitha, Ajjarapu, Srinivas, Murthy, S. Narasimha

“…[Display omitted] •In vitro skin clearance and binding of silymarin was evaluated.•Silymarin solubility was increased by SBE-β-CD–silymarin…”
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Corrigendum to “Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin” [Int. J. Pharm. 63 (2023) 122431] by Shankar, Vijay Kumar, Police, Anitha, Ajjarapu, Srinivas, Murthy, S. Narasimha

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Formulation and processing of solid self-emulsifying drug delivery systems (HME S-SEDDS): A single-step manufacturing process via hot-melt extrusion technology through response surface methodology by Raman Kallakunta, Venkata, Dudhipala, Narendar, Nyavanandi, Dinesh, Sarabu, Sandeep, Yadav Janga, Karthik, Ajjarapu, Srinivas, Bandari, Suresh, Repka, Michael A.

“…[Display omitted] The objective of the current study is the formulation development and manufacturing of solid self-emulsifying drug delivery systems (HME…”
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Development and characterization of Novel topical oil/PEG creams of voriconazole for the treatment of fungal infections by Shettar, Abhishek, Shankar, Vijay Kumar, Ajjarapu, Srinivas, Kulkarni, Vijay I., Repka, Micheal A., Murthy, S. Narasimha

“…Voriconazole (VRC), a second generation triazole derivative emerged as a promising candidate for the treatment of fungal infections. Voriconazole is…”
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Role of Thermodynamic Activity on the Topical Delivery of a Model Hydrophilic Drug by Ajjarapu, Srinivas

“…Drug release from the topical formulations and drug permeation into the skin from the topical formulations is influenced by formulation variables like…”
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A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the Solubility of Poorly Soluble Drugs: Effect of Formulation Variables on Dissolution and Stability by Sarabu, Sandeep, Kallakunta, Venkata Raman, Butreddy, Arun, Janga, Karthik Yadav, Ajjarapu, Srinivas, Bandari, Suresh, Zhang, Feng, Murthy, S. Narasimha, Repka, Michael A.

“…Fenofibrate is an effective lipid-lowering drug; however, its poor solubility and high log p (5.2) result in insufficient absorption from the gastrointestinal…”
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A Rapid Tool to Optimize Process Variables for Continuous Manufacturing of Metronidazole Ointment Using Melt Extrusion Technique by Ajjarapu, Srinivas, Rangappa, Srinath, Shankar, Vijay Kumar, Shettar, Abhishek, Kumar, H.N. Shiva, Kulkarni, Vijay I., Repka, Micheal A, Murthy, S. Narasimha

“…The use of hot-melt extrusion (HME) technique in the preparation of semi-solid products offers several advantages over conventional processes. However, the…”
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Continuous Manufacturing of Oil in Water (O/W) Emulgel by Extrusion Process by Echanur, V. Anusha, Matadh, Anusha V., Pragathi, S. G., Sarasija, S., Thean, Yeoh, Badruddoza, Abu Zayed, Shah, Jaymin, Kulkarni, Vijay, Ajjarapu, Srinivas, Reena, N. M., Shivakumar, H. N., Murthy, S. Narasimha

“…Pharmaceutical industries and drug regulatory agencies are inclining towards continuous manufacturing due to better control over the processing conditions and…”
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Evaluation of soluble fentanyl microneedles for loco-regional anti-nociceptive activity by Maurya, Abhijeet, Rangappa, Srinath, Bae, Jungeun, Dhawan, Trisha, Ajjarapu, Sankar Srinivas, Murthy, S. Narasimha

“…[Display omitted] The use of opioids for treating acute and chronic pain condition is a common clinical practice. When delivered systemically, the analgesic…”
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Microbial Stability of Pharmaceutical and Cosmetic Products by Dao, Huy, Lakhani, Prit, Police, Anitha, Kallakunta, Venkataraman, Ajjarapu, Sankar Srinivas, Wu, Kai-Wei, Ponkshe, Pranav, Repka, Michael A., Narasimha Murthy, S.

“…This review gives a brief overview about microbial contamination in pharmaceutical products. We discuss the distribution and potential sources of…”
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