Search Results - "Ajitkumar, Parthasarathi"

A method for the enrichment, isolation and validation of Mycobacterium smegmatis population surviving in the presence of bactericidal concentrations of rifampicin and moxifloxacin by Pradhan, Atul, Swaminath, Sharmada, Jakkala, Kishor, Ajitkumar, Parthasarathi

“…ABSTRACT The bacterial populations surviving in the presence of antibiotics contain cells that have gained genetic resistance, phenotypic resistance and…”
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Hypoxic Non-replicating Persistent Mycobacterium tuberculosis Develops Thickened Outer Layer That Helps in Restricting Rifampicin Entry by Jakkala, Kishor, Ajitkumar, Parthasarathi

“…Bacteria undergo adaptive morphological changes to survive under stress conditions. The present work documents the morphological changes in Mycobacterium…”
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A Minor Subpopulation of Mycobacteria Inherently Produces High Levels of Reactive Oxygen Species That Generate Antibiotic Resisters at High Frequency From Itself and Enhance Resister Generation From Its Major Kin Subpopulation by Nair, Rashmi Ravindran, Sharan, Deepti, Ajitkumar, Parthasarathi

“…Antibiotic-exposed bacteria produce elevated levels of reactive oxygen species (ROS), to which either they succumb or get mutated genome-wide to generate…”
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Mycobacterium tuberculosis Cells Surviving in the Continued Presence of Bactericidal Concentrations of Rifampicin in vitro Develop Negatively Charged Thickened Capsular Outer Layer That Restricts Permeability to the Antibiotic by Sebastian, Jees, Nair, Rashmi Ravindran, Swaminath, Sharmada, Ajitkumar, Parthasarathi

“…Majority of the cells in the bacterial populations exposed to lethal concentrations of antibiotics for prolonged duration succumbs to the antibiotics'…”
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Complete identity and expression of StfZ, the cis-antisense RNA to the mRNA of the cell division gene ftsZ, in Escherichia coli by Anand, Deepak, Jakkala, Kishor, Nair, Rashmi Ravindran, Sharan, Deepti, Pradhan, Atul, Mukkayyan, Nagaraja, Ajitkumar, Parthasarathi

“…Bacteria regulate FtsZ protein levels through transcriptional and translational mechanisms for proper cell division. A cis -antisense RNA, StfZ, produced from…”
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Percoll discontinuous density gradient centrifugation method for the fractionation of the subpopulations of Mycobacterium smegmatis and Mycobacterium tuberculosis from in vitro cultures by Vijay, Srinivasan, Nair, Rashmi Ravindran, Sharan, Deepti, Jakkala, Kishor, Ajitkumar, Parthasarathi

“…•The Percoll discontinuous density gradient centrifugation fractionates mycobacterial subpopulations, SCs and NCs.•High enrichment of the subpopulations of SCs…”
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Mycobacterial Populations Partly Change the Proportions of the Cells Undergoing Asymmetric/Symmetric Divisions in Response to Glycerol Levels in Growth Medium by Pradhan, Atul, Mukkayyan, Nagaraja, Jakkala, Kishor, Ajitkumar, Parthasarathi

“…Twenty to thirty percent of the septating mycobacterial cells of the mid-log phase population showed highly deviated asymmetric constriction during division…”
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Mycobacterium smegmatis strains genetically resistant to moxifloxacin emerge de novo from the moxifloxacin-surviving population containing high levels of superoxide, H2O2, hydroxyl radical, and Fe (II) by Paul, Avraneel, Nair, Rashmi, Jakkala, Kishor, Ajitkumar, Parthasarathi

“…Background: The antibiotic-exposed bacteria often contain the reactive oxygen species (ROS), hydroxyl radical, which inflicts genome-wide mutations, causing…”
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Unveiling Unusual Features of Formation of Septal Partition and Constriction in Mycobacteria—an Ultrastructural Study by Vijay, Srinivasan, Anand, Deepak, Ajitkumar, Parthasarathi

“…The ultrastructural functions of the electron-dense glycopeptidolipid-containing outermost layer (OL), the arabinogalactan-mycolic acid-containing…”
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Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of Mycobacterium smegmatis globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation by Swaminath, Sharmada, Pradhan, Atul, Nair, Rashmi Ravindran, Ajitkumar, Parthasarathi

“…•Physiological role of mono-ADP-ribosyl transferase (Arr) of Mycobacterium smegmatis revealed.•Arr is required to maintain ROS levels in actively growing M…”
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Growth and division mechanisms by which genetic resisters emerge from the rifampicin-surviving population of differentially antibiotic-susceptible mycobacterial subpopulations by Jakkala, Kishor, Paul, Avraneel, Nair, Rashmi, Swaminath, Sharmada, Pradhan, Atul, Ajitkumar, Parthasarathi

“…Background: We recently reported the de novo emergence of unusually high numbers of antibiotic resisters from the in vitro cultures of Mycobacterium…”
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The H2O2 inherently released by the mycobacterial minor subpopulation enhances the survival of the major kin subpopulation against rifampicin by Nair, Rashmi Ravindran, Sharan, Deepti, Srinivasan, Vijay, Mukkayyan, Nagaraja, Jakkala, Kishor, Ajitkumar, Parthasarathi

“…•Stress survival of mycobacterial minor (SCs) and major (NCs) subpopulations.•The SCs enhance survival of the NCs against rifampicin.•H2O2 released by the SCs…”
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Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB by JOSEPH, Jeena, MUDDULURU, Giridhar, ANTONY, Sini, VASHISTHA, Surabhi, AJITKUMAR, Parthasarathi, SOMASUNDARAM, Kumaravel

“…Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a short chain fatty acid,…”
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NDK Interacts with FtsZ and Converts GDP to GTP to Trigger FtsZ Polymerisation--A Novel Role for NDK by Mishra, Saurabh, Jakkala, Kishor, Srinivasan, Ramanujam, Arumugam, Muthu, Ranjeri, Raghavendra, Gupta, Prabuddha, Rajeswari, Haryadi, Ajitkumar, Parthasarathi

“…Nucleoside diphosphate kinase (NDK), conserved across bacteria to humans, synthesises NTP from NDP and ATP. The eukaryotic homologue, the NDPK, uses ATP to…”
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Redox-dependent condensation of the mycobacterial nucleoid by WhiB4 by Chawla, Manbeena, Mishra, Saurabh, Anand, Kushi, Parikh, Pankti, Mehta, Mansi, Vij, Manika, Verma, Taru, Singh, Parul, Jakkala, Kishor, Verma, H.N., AjitKumar, Parthasarathi, Ganguli, Munia, Narain Seshasayee, Aswin Sai, Singh, Amit

“…Oxidative stress response in bacteria is mediated through coordination between the regulators of oxidant-remediation systems (e.g. OxyR, SoxR) and nucleoid…”
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MtFtsX a predicted membrane domain of ABC transporter complex MtFtsEX of Mycobacterium tuberculosis interacts with the cell division protein MtFtsZ by Mir, Mushtaq, Srinivasan, Ramanujam, Ajitkumar, Parthasarathi

“…Background: Bacterial cytokinesis is orchestrated by a complex of dozen of proteins called 'divisome' at the mid-cell site. FtsZ, the eukaryotic tubulin…”
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Transcriptional Analysis of the Principal Cell Division Gene, ftsZ, of Mycobacterium tuberculosis by ROY, Sougata, AJITKUMAR, Parthasarathi

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis by Srinivasan, Ramanujam, Anilkumar, Gopalakrishnapillai, Rajeswari, Harayadi, Ajitkumar, Parthasarathi

“…Abstract FtsH is a membrane-bound ATP-dependent zinc-metalloprotease which proteolytically regulates the levels of specific membrane and cytoplasmic proteins…”
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Genetic resisters to antibiotics in Escherichia coli arise from the antibiotic-surviving population containing three reactive oxygen species by Paul, Avraneel, Nair, Rashmi Ravindran, Ajitkumar, Parthasarathi

“…ABSTRACT Antibiotic-exposed bacteria acquire genetic mutations and emerge as antibiotic-resistant clones that thwart treatment of bacterial diseases…”
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Highly fluorescent GFP m 2+ ‐based genome integration‐proficient promoter probe vector to study Mycobacterium tuberculosis promoters in infected macrophages by Roy, Sougata, Narayana, Yeddula, Narayanaswamy Balaji, Kithiganahalli, Ajitkumar, Parthasarathi

“…Summary Study of activity of cloned promoters in slow‐growing Mycobacterium tuberculosis during long‐term growth conditions in vitro or inside macrophages,…”
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