Search Results - "Ajenjo, Nuria"

A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis by Zhu, Lucía, Retana, Diana, García‐Gómez, Pedro, Álvaro‐Espinosa, Laura, Priego, Neibla, Masmudi‐Martín, Mariam, Yebra, Natalia, Miarka, Lauritz, Hernández‐Encinas, Elena, Blanco‐Aparicio, Carmen, Martínez, Sonia, Sobrino, Cecilia, Ajenjo, Nuria, Artiga, Maria‐Jesus, Ortega‐Paino, Eva, Torres‐Ruiz, Raúl, Rodríguez‐Perales, Sandra, Soffietti, Riccardo, Bertero, Luca, Cassoni, Paola, Weiss, Tobias, Muñoz, Javier, Sepúlveda, Juan Manuel, González‐León, Pedro, Jiménez‐Roldán, Luis, Moreno, Luis Miguel, Esteban, Olga, Pérez‐Núñez, Ángel, Hernández‐Laín, Aurelio, Toldos, Oscar, Ruano, Yolanda, Alcázar, Lucía, Blasco, Guillermo, Fernández‐Alén, José, Caleiras, Eduardo, Lafarga, Miguel, Megías, Diego, Graña‐Castro, Osvaldo, Nör, Carolina, Taylor, Michael D, Young, Leonie S, Varešlija, Damir, Cosgrove, Nicola, Couch, Fergus J, Cussó, Lorena, Desco, Manuel, Mouron, Silvana, Quintela‐Fandino, Miguel, Weller, Michael, Pastor, Joaquín, Valiente, Manuel, de la Lama‐Zaragoza, Adolfo, Calero‐Felix, Lourdes, Fiaño‐Valverde, Concepcion, Delgado‐López, Pedro David, Montalvo‐Afonso, Antonio, Pascual‐Llorente, Mar, Díaz‐Piqueras, Ángela, Nam‐Cha, SH, Barrena López, Cristina, Plans Ahicart, Gerard, Martínez‐Saez, Elena, Ramón y Cajal, Santiago, Nicolás, Pilar

“…We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing…”
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Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid Leukemia Cells by Ajenjo, Nuria, Canon, Estela, Sanchez-Perez, Isabel, Matallanas, David, Leon, Javier, Perona, Rosario, Crespo, Piero

“…ERKs, mitogen-activated protein kinases, are well characterized as key mediators in the conveyance of signals that promote cell survival in cells of…”
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Determination of viability of human cartilage allografts by a rapid and quantitative method not requiring cartilage digestion by López, Carmen, Ajenjo, Nuria, Muñoz-Alonso, Maria J, Farde, Pilar, León, J, Gómez-Cimiano, J

“…Fresh osteochondral allograft transplantation is increasingly used for the treatment of cartilage pathologies of the knee. It is believed that transplantation…”
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Myeloid Leukemia Cell Growth and Differentiation Are Independent of Mitogen-activated Protein Kinase ERK1/2 Activation by Ajenjo, Nuria, Aaronson, David S., Ceballos, Eva, Richard, Carlos, León, Javier, Crespo, Piero

“…The mitogen-activated protein kinase ERK1/2 pathway is essential in the control of cell proliferation and differentiation in most cellular systems. As such, it…”
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The Rho Family GTPase Cdc42 Regulates the Activation of Ras/MAP Kinase by the Exchange Factor Ras-GRF by Arozarena, I, Aaronson, D S, Matallanas, D, Sanz, V, Ajenjo, N, Tenbaum, S P, Teramoto, H, Ighishi, T, Zabala, J C, Gutkind, J S, Crespo, P

“…The Ras guanine-nucleotide exchange factor Ras-GRF/Cdc25 Mn harbors a complex array of structural motifs that include a Dbl-homology (DH) domain, usually found…”
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Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21Cip1 Pathway by Vaqué, Jose P., Navascues, Joaquin, Shiio, Yuzuru, Laiho, Marikki, Ajenjo, Nuria, Mauleon, Itsaso, Matallanas, David, Crespo, Piero, León, Javier

“…Even though RAS usually acts as a dominant transforming oncogene, in primary fibroblasts and some established cell lines Ras inhibits proliferation. This can…”
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p38α MAP Kinase as a Sensor of Reactive Oxygen Species in Tumorigenesis by Dolado, Ignacio, Swat, Aneta, Ajenjo, Nuria, De Vita, Gabriella, Cuadrado, Ana, Nebreda, Angel R.

“…p38α is a stress-activated protein kinase that negatively regulates malignant transformation induced by oncogenic H-Ras, although the mechanisms involved are…”
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Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism by Monteiro, Cátia, Miarka, Lauritz, Perea-García, María, Priego, Neibla, García-Gómez, Pedro, Álvaro-Espinosa, Laura, de Pablos-Aragoneses, Ana, Yebra, Natalia, Retana, Diana, Baena, Patricia, Fustero-Torre, Coral, Graña-Castro, Osvaldo, Troulé, Kevin, Caleiras, Eduardo, Tezanos, Patricia, Muela, Pablo, Cintado, Elisa, Trejo, José Luis, Sepúlveda, Juan Manuel, González-León, Pedro, Jiménez-Roldán, Luis, Moreno, Luis Miguel, Esteban, Olga, Pérez-Núñez, Ángel, Hernández-Lain, Aurelio, Mazarico Gallego, José, Ferrer, Irene, Suárez, Rocío, Garrido-Martín, Eva M., Paz-Ares, Luis, Dalmasso, Celine, Cohen-Jonathan Moyal, Elizabeth, Siegfried, Aurore, Hegarty, Aisling, Keelan, Stephen, Varešlija, Damir, Young, Leonie S., Mohme, Malte, Goy, Yvonne, Wikman, Harriet, Fernández-Alén, Jose, Blasco, Guillermo, Alcázar, Lucía, Cabañuz, Clara, Grivennikov, Sergei I., Ianus, Andrada, Shemesh, Noam, Faria, Claudia, Lee, Rebecca, Lorigan, Paul, Le Rhun, Emilie, Weller, Michael, Soffietti, Riccardo, Bertero, Luca, Ricardi, Umberto, Bosch-Barrera, Joaquim, Sais, Elia, Teixidor, Eduard, Hernández-Martínez, Alejandro, Calvo, Alfonso, Aristu, Javier, Martin, Santiago M., Gonzalez, Alvaro, Adler, Omer, Erez, Neta, Sobrino, Cecilia, Ajenjo, Nuria, Artiga, Maria-Jesus, Ortega-Paino, Eva, Valiente, Manuel

“…© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits by Sanchez-Aguilera, Alberto, Masmudi-Martín, Mariam, Navas-Olive, Andrea, Baena, Patricia, Hernández-Oliver, Carolina, Priego, Neibla, Cordón-Barris, Lluís, Alvaro-Espinosa, Laura, García, Santiago, Martínez, Sonia, Lafarga, Miguel, Sobrino, Cecilia, Ajenjo, Nuria, Artiga, Maria-Jesus, Ortega-Paino, Eva, García-Calvo, Virginia, Pérez-Núñez, Angel, González-León, Pedro, Jiménez-Roldán, Luis, Moreno, Luis Miguel, Esteban, Olga, Sepúlveda, Juan Manuel, Toldos, Oscar, Laín, Aurelio Hernández, Arenas, Alicia, Blasco, Guillermo, Alén, José Fernández, Zaragoza, Adolfo de la Lama, Núñez, Antía Domínguez, Calero, Lourdes, Valverde, Concepción Fiaño, Piñeiro, Ana González, Delgado López, Pedro David, Pascual, Mar, Ahicart, Gerard Plans, Otín, Begoña Escolano, Lin, Michael Z, Al-Shahrour, Fátima, Menendez de la Prida, Liset, Valiente, Manuel

“…A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how brain metastasis co-opts the…”
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Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors by Martínez-González, Sonia, Rodríguez-Arístegui, Sonsoles, Gómez de la Oliva, Cristina Ana, Hernández, Ana Isabel, González Cantalapiedra, Esther, Varela, Carmen, García, Ana Belén, Rabal, Obdulia, Oyarzabal, Julen, Bischoff, James R., Klett, Javier, Albarrán, María Isabel, Cebriá, Antonio, Ajenjo, Nuria, García-Serelde, Beatriz, Gómez-Casero, Elena, Cuadrado-Urbano, Manuel, Cebrián, David, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…PIM kinase family (PIM-1, PIM-2 and PIM-3) is an appealing target for the discovery and development of selective inhibitors, useful in various disease…”
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Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors by Martínez-González, Sonia, Alvarez, Rosa M, Martín, José I, García, Ana Belén, Riesco-Fagundo, Concepción, Varela, Carmen, Rodríguez Hergueta, Antonio, González Cantalapiedra, Esther, Albarrán, M. I, Gómez-Casero, Elena, Cebriá, Antonio, Aguirre, Enara, Ajenjo, Nuria, Cebrián, David, Di Geronimo, Bruno, Cunningham, Darren, O’Neill, Michael, Dave, Harish P. G, Blanco-Aparicio, Carmen, Pastor, Joaquín

“…The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising…”
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Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition by Blanco-Aparicio, Carmen, Collazo, Ana María García, Oyarzabal, Julen, Leal, Juan F, Albarán, María Isabel, Lima, Francisco Ramos, Pequeño, Belén, Ajenjo, Nuria, Becerra, Mercedes, Alfonso, Patricia, Reymundo, María Isabel, Palacios, Irene, Mateos, Genoveva, Quiñones, Helena, Corrionero, Ana, Carnero, Amancio, Pevarello, Paolo, Lopez, Ana Rodríguez, Fominaya, Jesús, Pastor, Joaquín, Bischoff, James R

“…Abstract The serine/threonine Pim 1 kinase is an oncogene whose expression is deregulated in several human cancers. Overexpression of Pim 1 facilitates cell…”
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Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors by Pastor, Joaquín, Oyarzabal, Julen, Saluste, Gustavo, Alvarez, Rosa María, Rivero, Virginia, Ramos, Francisco, Cendón, Elena, Blanco-Aparicio, Carmen, Ajenjo, Nuria, Cebriá, Antonio, Albarrán, M.I., Cebrián, David, Corrionero, Ana, Fominaya, Jesús, Montoya, Guillermo, Mazzorana, Marco

“…PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production…”
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Abstract A275: Co-targeting PIM and PI3K/mTOR pathways with a single molecule: Novel orally available combined PIM/PI3K and PIM/PI3K/mTOR kinase inhibitors by Blanco Aparicio, Carmen, Renner, Oliver, Gomez-Casero, Elena, Cebriá, Antonio, Ajenjo, Nuria, Aguirre, Enara, Cebrián, David, Rodriguez de Miguel, Mª Carmen, Pequeño, Belén, Albarrán, MªIsabel, Riesco, Rosario, García, Ana Belén, Alvarez, Rosa, O'Neill, Michael, Martinez, Sonia, Pastor, Joaquin

“…Abstract The PI3K/AKT pathway is commonly activated in human cancer. Multiple small-molecule inhibitors have been developed to target PI3K/mTOR or AKT kinases,…”
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Abstract B228: Discovery of 6-Methyl-3-aryl-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-ylamine compounds as Pim kinase inhibitors with potent activity in tumoral cell lines and special binding mode by Aparicio, Carmen Blanco, Martinez, Sonia, Garcia-Serelde, Beatriz, Garcia-Collazo, Ana Maria, Ajenjo, Nuria, Noya, Beatriz, Corrionero, Ana, Rodriguez, Antonio, Cebrian, David, Martin, Jose Ignacio, Casas, Estela, Pierre, Carl-Gustave, Cebria, Antonio, Gonzalez, Esther, Palacios, Irene, Mazzerano, Marco, Mateos, Genoveva, Hernandez, Ana Isabel, Albarran, M Isabel, Ramos, Francisco, Reymundo, MIsabel, Salgado, Antonio, Fominaya, Jesus, Montoya, Guillermo, Pastor, Joaquin

“…Abstract Proviral integration site for Moloney murine leukemia virus (PIM) kinases are potent oncogens. Pim-1, 2 and 3 are highly conserved kinases that have…”
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p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis by Dolado, Ignacio, Swat, Aneta, Ajenjo, Nuria, De Vita, Gabriella, Cuadrado, Ana, Nebreda, Angel R

“…p38alpha is a stress-activated protein kinase that negatively regulates malignant transformation induced by oncogenic H-Ras, although the mechanisms involved…”
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Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21 super(Cip1) Pathway by Vaque, Jose P, Navascues, Joaquin, Shiio, Yuzuru, Laiho, Marikki, Ajenjo, Nuria, Mauleon, Itsaso, Matallanas, David, Crespo, Piero, Leon, Javier

“…Even though RAS usually acts as a dominant transforming oncogene, in primary fibroblasts and some established cell lines Ras inhibits proliferation. This can…”
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Regulation of c-myc and max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase c modifiers : C-myc is down-regulated but does not inhibit differentiation by LERGA, A, CRESPO, P, GUTKIND, S, LEON, J, BERCIANO, M, DELGADO, M. D, CANELLES, M, CALES, C, RICHARD, C, CEBALLOS, E, GUTIERREZ, P, AJENJO, N

“…We have studied the regulation and role of c-Myc and Max in the differentiation pathways induced in K562 cells by 12-O-tetradecanoyl phorbol-13 acetate (TPA)…”
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