Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1-/- Rats

Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1-/- Rats

Cognitive impairments appear at or before motor signs in about one third of patients with Parkinson's disease (PD) and have a cumulative prevalence of roughly 80% overall. These deficits exact an unrelenting toll on patients' quality and activities of daily life due in part to a lack of av...

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Published in:Frontiers in behavioral neuroscience Vol. 16; p. 951268
Main Authors: Pinizzotto, Claudia C, Dreyer, Katherine M, Aje, Oluwagbohunmi A, Caffrey, Ryan M, Madhira, Keertana, Kritzer, Mary F
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 06-12-2022
Frontiers Media S.A
Subjects:
Alzheimer's disease
Animal cognition
Behavioral Neuroscience
cognition
Cognitive ability
hippocampus
Information processing
Laboratory animals
Memory
Movement disorders
Mutation
Neurodegenerative diseases
Parkinson's disease
Pattern recognition
perirhinal cortex
PTEN protein
PTEN-induced putative kinase
PTEN-induced putative kinase1
Rodents
Spatial memory
Visual discrimination
Visual pathways
United States > US
PTEN-induced putative kinase1
cognition
hippocampus
spatial memory
perirhinal cortex
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Summary:Cognitive impairments appear at or before motor signs in about one third of patients with Parkinson's disease (PD) and have a cumulative prevalence of roughly 80% overall. These deficits exact an unrelenting toll on patients' quality and activities of daily life due in part to a lack of available treatments to ameliorate them. This study used three well-validated novel object recognition-based paradigms to explore the suitability of rats with knockout of the PTEN-induced putative kinase1 gene ( ) for investigating factors that induce cognitive decline in PD and for testing new ways to mitigate them. Longitudinal testing of rats from 3-9 months of age revealed significant impairments in male -/- rats compared to wild type controls in Novel Object Recognition, Novel Object Location and Object-in-Place tasks. Task-specific differences in the progression of object discrimination/memory deficits across age were also seen. Finally, testing using an elevated plus maze, a tapered balance beam and a grip strength gauge showed that in all cases recognition memory deficits preceded potentially confounding impacts of gene knockout on affect or motor function. Taken together, these findings suggest that knockout of the gene negatively impacts the brain circuits and/or neurochemical systems that support performance in object recognition tasks. Further investigations using -/- rats and object recognition memory tasks should provide new insights into the neural underpinnings of the visual recognition memory and visuospatial information processing deficits that are often seen in PD patients and accelerate the pace of discovery of better ways to treat them.
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This article was submitted to Learning and Memory, a section of the journal Frontiers in Behavioral Neuroscience
Reviewed by: Marta Méndez, University of Oviedo, Spain; Vanessa Costhek Abilio, Federal University of São Paulo, Brazil
Edited by: Flávio F. Barbosa, Federal University of Paraíba, Brazil
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2022.951268