Disruption of cerebellar cholinergic system in hypoxic neonatal rats and its regulation with glucose, oxygen and epinephrine resuscitations

Graphical abstract Highlights ► Cerebellar muscarinic M1/2/3 receptor was decreased due to neonatal hypoxia. ► Acetylcholine metabolism was also disturbed – leading to metabolic shift. ► Glucose resuscitation, alone and with oxygen, reversed the cholinergic alterations. ► Common clinical practice of...

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Bibliographic Details
Published in:	Neuroscience Vol. 236; pp. 253 - 261
Main Authors:	Anju, T.R, Ajayan, M.S, Paulose, C.S
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 16-04-2013 Elsevier
Subjects:	Acetylcholine - metabolism acetylcholine easterase Animals Animals, Newborn Biological and medical sciences Cerebellum - metabolism cholineacetyl transferase Epinephrine - pharmacology Fundamental and applied biological sciences. Psychology glucose Glucose - pharmacology Hypoxia, Brain - metabolism muscarinic receptor neonatal hypoxia Neurology oxygen Oxygen - pharmacology Rats Rats, Wistar Real-Time Polymerase Chain Reaction Receptors, Muscarinic - metabolism Vertebrates: nervous system and sense organs AChE glucose QNB ACh neonatal hypoxia quinuclidinylbenzilate S.E.M muscarinic receptor choline acetyltransferase analysis of variance CoA ANOVA cholineacetyl transferase ROS reactive oxygen species acetylcholine esterase ChAT choline O acetyltransferase acetylcholine easterase acetylcholine standard error of the mean oxygen Epinephrine Cerebellum Oxygen Rat Enzyme Transferases Rodentia Central nervous system Environmental factor Glucose Catecholamine Encephalon Cholinergic receptor Vertebrata Mammalia Animal Neurotransmitter Hypoxia Acetylcholine Muscarinic receptor
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Summary:	Graphical abstract Highlights ► Cerebellar muscarinic M1/2/3 receptor was decreased due to neonatal hypoxia. ► Acetylcholine metabolism was also disturbed – leading to metabolic shift. ► Glucose resuscitation, alone and with oxygen, reversed the cholinergic alterations. ► Common clinical practice of 100% oxygen or epinephrine upset the cholinergic system. ► This highlights the importance of glucose supplementation in neonatal care to hypoxia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.056