Search Results - "Ajani, A"

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression by Lei, Guang, Zhang, Yilei, Koppula, Pranavi, Liu, Xiaoguang, Zhang, Jie, Lin, Steven H., Ajani, Jaffer A., Xiao, Qin, Liao, Zhongxing, Wang, Hui, Gan, Boyi

“…Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified as a natural tumor suppression mechanism. Here, we show that…”
Get full text

Drug resistance and Cancer stem cells by Li, Yuan, Wang, Zhenning, Ajani, Jaffer A, Song, Shumei

“…Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds,…”
Get full text

Cancer Stem Cells: The Promise and the Potential by Ajani, Jaffer A, Song, Shumei, Hochster, Howard S, Steinberg, Ira B

“…Despite the advancement of treatment modalities, many cancer patients experience tumor recurrence and metastasis at regional or distant sites. Evolving…”
Get full text

Gastric cancer—molecular and clinical dimensions by Wadhwa, Roopma, Song, Shumei, Lee, Ju-Seog, Yao, Yixin, Wei, Qingyi, Ajani, Jaffer A.

“…Key Points Globally, gastric cancer is the fourth most common cancer in men and fifth most common cancer in women Helicobacter pylori is the most intriguing…”
Get full text

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer by Shitara, Kohei, Ajani, Jaffer A., Moehler, Markus, Garrido, Marcelo, Gallardo, Carlos, Shen, Lin, Yamaguchi, Kensei, Wyrwicz, Lucjan, Skoczylas, Tomasz, Bragagnoli, Arinilda Campos, Liu, Tianshu, Tehfe, Mustapha, Elimova, Elena, Bruges, Ricardo, Zander, Thomas, de Azevedo, Sergio, Kowalyszyn, Ruben, Pazo-Cid, Roberto, Schenker, Michael, Cleary, James M., Yanez, Patricio, Feeney, Kynan, Karamouzis, Michalis V., Poulart, Valerie, Lei, Ming, Xiao, Hong, Kondo, Kaoru, Li, Mingshun, Janjigian, Yelena Y.

“…Standard first-line chemotherapy results in disease progression and death within one year in most patients with human epidermal growth factor receptor 2…”
Get full text

Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma by Doki, Yuichiro, Ajani, Jaffer A, Kato, Ken, Xu, Jianming, Wyrwicz, Lucjan, Motoyama, Satoru, Ogata, Takashi, Kawakami, Hisato, Hsu, Chih-Hung, Adenis, Antoine, El Hajbi, Farid, Di Bartolomeo, Maria, Braghiroli, Maria I, Holtved, Eva, Ostoich, Sandra A, Kim, Hye R, Ueno, Masaki, Mansoor, Wasat, Yang, Wen-Chi, Liu, Tianshu, Bridgewater, John, Makino, Tomoki, Xynos, Ioannis, Liu, Xuan, Lei, Ming, Kondo, Kaoru, Patel, Apurva, Gricar, Joseph, Chau, Ian, Kitagawa, Yuko

“…Previously untreated patients with advanced esophageal cancer were randomly assigned to receive chemotherapy alone, chemotherapy plus nivolumab, or nivolumab…”
Get full text

Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial by Shah, Manish A., Shitara, Kohei, Ajani, Jaffer A., Bang, Yung-Jue, Enzinger, Peter, Ilson, David, Lordick, Florian, Van Cutsem, Eric, Gallego Plazas, Javier, Huang, Jing, Shen, Lin, Oh, Sang Cheul, Sunpaweravong, Patrapim, Soo Hoo, Hwoei Fen, Turk, Haci Mehmet, Oh, Mok, Park, Jung Wook, Moran, Diarmuid, Bhattacharya, Pranob, Arozullah, Ahsan, Xu, Rui-Hua

“…There is an urgent need for first-line treatment options for patients with human epidermal growth factor receptor 2 (HER2)-negative, locally advanced…”
Get full text

Cancer incidence rates and trends among children and adolescents in the United States, 2001-2009 by Siegel, David A, King, Jessica, Tai, Eric, Buchanan, Natasha, Ajani, Umed A, Li, Jun

“…Cancer continues to be the leading disease-related cause of death among children and adolescents in the United States. More current information is needed to…”
Get full text

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade by Shen, Jianfeng, Ju, Zhenlin, Zhao, Wei, Wang, Lulu, Peng, Yang, Ge, Zhongqi, Nagel, Zachary D., Zou, Jun, Wang, Chen, Kapoor, Prabodh, Ma, Xiangyi, Ma, Ding, Liang, Jiyong, Song, Shumei, Liu, Jinsong, Samson, Leona D., Ajani, Jaffer A., Li, Guo-Min, Liang, Han, Shen, Xuetong, Mills, Gordon B., Peng, Guang

“…ARID1A (the AT-rich interaction domain 1A, also known as BAF250a ) is one of the most commonly mutated genes in cancer 1 , 2 . The majority of ARID1A mutations…”
Get full text

Tislelizumab Versus Chemotherapy as Second-Line Treatment for Advanced or Metastatic Esophageal Squamous Cell Carcinoma (RATIONALE-302): A Randomized Phase III Study by Shen, Lin, Kato, Ken, Kim, Sung-Bae, Ajani, Jaffer A, Zhao, Kuaile, He, Zhiyong, Yu, Xinmin, Shu, Yongqian, Luo, Qi, Wang, Jufeng, Chen, Zhendong, Niu, Zuoxing, Zhang, Longzhen, Yi, Tienan, Sun, Jong-Mu, Chen, Jianhua, Yu, Guohua, Lin, Chen-Yuan, Hara, Hiroki, Bi, Qing, Satoh, Taroh, Pazo-Cid, Roberto, Arkenau, Hendrick-Tobias, Borg, Christophe, Lordick, Florian, Li, Liyun, Ding, Ningning, Tao, Aiyang, Shi, Jingwen, Van Cutsem, Eric

“…Patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) have poor prognosis. For these patients, treatment options are limited after…”
Get full text

Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System by KOHLER, Betsy A, WARD, Elizabeth, MCCARTHY, Bridget J, SCHYMURA, Maria J, RIES, Lynn A. G, EHEMAN, Christie, JEMAL, Ahmedin, ANDERSON, Robert N, AJANI, Umed A, EDWARDS, Brenda K

“…The American Cancer Society, the Centers for Disease Control and Prevention (CDC), the National Cancer Institute, and the North American Association of Central…”
Get full text

HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology by Bartley, Angela N, Washington, Mary Kay, Colasacco, Carol, Ventura, Christina B, Ismaila, Nofisat, Benson, 3rd, Al B, Carrato, Alfredo, Gulley, Margaret L, Jain, Dhanpat, Kakar, Sanjay, Mackay, Helen J, Streutker, Catherine, Tang, Laura, Troxell, Megan, Ajani, Jaffer A

“…Context ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker established for selection of a specific therapy for patients with…”
Get full text

Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project by Sohn, Bo Hwa, Hwang, Jun-Eul, Jang, Hee-Jin, Lee, Hyun-Sung, Oh, Sang Cheul, Shim, Jae-Jun, Lee, Keun-Wook, Kim, Eui Hyun, Yim, Sun Young, Lee, Sang Ho, Cheong, Jae-Ho, Jeong, Woojin, Cho, Jae Yong, Kim, Joohee, Chae, Jungsoo, Lee, Jeeyun, Kang, Won Ki, Kim, Sung, Noh, Sung Hoon, Ajani, Jaffer A, Lee, Ju-Seog

“…The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein-Barr virus (EBV), microsatellite instability…”
Get full text

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma by Wang, Ruiping, Dang, Minghao, Harada, Kazuto, Han, Guangchun, Wang, Fang, Pool Pizzi, Melissa, Zhao, Meina, Tatlonghari, Ghia, Zhang, Shaojun, Hao, Dapeng, Lu, Yang, Zhao, Shuangtao, Badgwell, Brian D., Blum Murphy, Mariela, Shanbhag, Namita, Estrella, Jeannelyn S., Roy-Chowdhuri, Sinchita, Abdelhakeem, Ahmed Adel Fouad, Wang, Yuanxin, Peng, Guang, Hanash, Samir, Calin, George A., Song, Xingzhi, Chu, Yanshuo, Zhang, Jianhua, Li, Mingyao, Chen, Ken, Lazar, Alexander J., Futreal, Andrew, Song, Shumei, Ajani, Jaffer A., Wang, Linghua

“…Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of ITH remain poorly understood. We performed single-cell…”
Get full text

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance by Uchihara, Tomoyuki, Miyake, Keisuke, Yonemura, Atsuko, Komohara, Yoshihiro, Itoyama, Rumi, Koiwa, Mayu, Yasuda, Tadahito, Arima, Kota, Harada, Kazuto, Eto, Kojiro, Hayashi, Hiromitsu, Iwatsuki, Masaaki, Iwagami, Shiro, Baba, Yoshifumi, Yoshida, Naoya, Yashiro, Masakazu, Masuda, Mari, Ajani, Jaffer A, Tan, Patrick, Baba, Hideo, Ishimoto, Takatsugu

“…Extracellular vesicles (EV) from cancer-associated fibroblasts (CAF) are composed of diverse payloads. Although CAFs impact the aggressive characteristics of…”
Get full text

A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma by Song, Shumei, Xie, Min, Scott, Ailing W, Jin, Jiankang, Ma, Lang, Dong, Xiaochuan, Skinner, Heath D, Johnson, Randy L, Ding, Sheng, Ajani, Jaffer A

“…Mounting evidence suggests that the Hippo coactivator Yes-associated protein 1 (YAP1) is a major mediator of cancer stem cell (CSC) properties, tumor…”
Get full text

The role of microRNAs in cancers of the upper gastrointestinal tract by Song, Shumei, Ajani, Jaffer A.

“…Upper gastrointestinal tract cancers (UGICs) pose a major health risk around the world, and therapeutic improvements have been very slow and small. Increased…”
Get full text

Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer by Lin, Steven H, Hobbs, Brian P, Verma, Vivek, Tidwell, Rebecca S, Smith, Grace L, Lei, Xiudong, Corsini, Erin M, Mok, Isabel, Wei, Xiong, Yao, Luyang, Wang, Xin, Komaki, Ritsuko U, Chang, Joe Y, Chun, Stephen G, Jeter, Melenda D, Swisher, Stephen G, Ajani, Jaffer A, Blum-Murphy, Mariela, Vaporciyan, Ara A, Mehran, Reza J, Koong, Albert C, Gandhi, Saumil J, Hofstetter, Wayne L, Hong, Theodore S, Delaney, Thomas F, Liao, Zhongxing, Mohan, Radhe

“…Whether dosimetric advantages of proton beam therapy (PBT) translate to improved clinical outcomes compared with intensity-modulated radiation therapy (IMRT)…”
Get full text

Updated Analysis of SWOG-Directed Intergroup Study 0116: A Phase III Trial of Adjuvant Radiochemotherapy Versus Observation After Curative Gastric Cancer Resection by SMALLEY, Stephen R, BENEDETTI, Jacqueline K, STEMMERMANN, Grant N, BLANKE, Charles D, MACDONALD, John S, HALLER, Daniel G, HUNDAHL, Scott A, ESTES, Norman C, AJANI, Jaffer A, GUNDERSON, Leonard L, GOLDMAN, Bryan, MARTENSON, James A, JESSUP, J. Milburn

“…Surgical resection of gastric cancer has produced suboptimal survival despite multiple randomized trials that used postoperative chemotherapy or more…”
Get full text

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype by Oh, Sang Cheul, Sohn, Bo Hwa, Cheong, Jae-Ho, Kim, Sang-Bae, Lee, Jae Eun, Park, Ki Cheong, Lee, Sang Ho, Park, Jong-Lyul, Park, Yun-Yong, Lee, Hyun-Sung, Jang, Hee-Jin, Park, Eun Sung, Kim, Sang-Cheol, Heo, Jeonghoon, Chu, In-Sun, Jang, You-Jin, Mok, Young-Jae, Jung, WonKyung, Kim, Baek-Hui, Kim, Aeree, Cho, Jae Yong, Lim, Jae Yun, Hayashi, Yuki, Song, Shumei, Elimova, Elena, Estralla, Jeannelyn S., Lee, Jeffrey H., Bhutani, Manoop S., Lu, Yiling, Liu, Wenbin, Lee, Jeeyun, Kang, Won Ki, Kim, Sung, Noh, Sung Hoon, Mills, Gordon B., Kim, Seon-Young, Ajani, Jaffer A., Lee, Ju-Seog

“…Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes,…”
Get full text