Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate

Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. We established the Men of African Descent and Carcinoma of...

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Published in:	Journal of global oncology Vol. 4; no. 4; pp. 1 - 14
Main Authors:	Andrews, Caroline, Fortier, Brian, Hayward, Amy, Lederman, Ruth, Petersen, Lindsay, McBride, Jo, Petersen, Desiree C, Ajayi, Olabode, Kachambwa, Paidamoyo, Seutloali, Moleboheng, Shoko, Aubrey, Mokhosi, Mamokhosana, Hiller, Reinhard, Adams, Marcia, Ongaco, Chrissie, Pugh, Elizabeth, Romm, Jane, Shelford, Tameka, Chinegwundoh, Frank, Adusei, Ben, Mante, Sunny, Snyper, Nana Yaa, Agalliu, Ilir, Lounsbury, David W, Rohan, Thomas, Orfanos, Alex, Quintana, Yuri, Jacobson, Judith S, Neugut, Alfred I, Gelmann, Edward, Lachance, Joseph, Dial, Cherif, Diallo, Thierno Amadou, Jalloh, Mohamed, Gueye, Serigne Magueye, Kane, Papa Moussa Sène, Diop, Halimatou, Ndiaye, Anna Julienne, Sall, Amina Sow, Toure-Kane, Ndeye Coumba, Onyemata, Ezenwa, Abimiku, Alash'le, Adjei, Andrew A, Biritwum, Richard, Gyasi, Richard, Kyei, Mathew, Mensah, James E, Okine, Julian, Okyne, Vicky, Rockson, Isabella, Tay, Evelyn, Tettey, Yao, Yeboah, Edward, Chen, Wenlong C, Singh, Elvira, Cook, Michael B, Duffy, Christine N, Hsing, Ann, Soo, Cassandra Claire, Fernandez, Pedro, Irusen, Hayley, Aisuodionoe-Shadrach, Oseremen, Jamda, Abubakar Mustapha, Olabode, Peter Oluwole, Nwegbu, Maxwell Madueke, Ajibola, Olalekan Hafees, Ajamu, Olushola Jeremiah, Ambuwa, Yakubu Garba, Adebiyi, Akindele Olupelumi, Asuzu, Michael, Ogunbiyi, Olufemi, Popoola, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Odiaka, Emeka, Makinde, Ifeoluwa, Joffe, Maureen, Pentz, Audrey, Rebbeck, Timothy R
Format:	Journal Article
Language:	English
Published:	United States American Society of Clinical Oncology 01-09-2018
Subjects:	Baltimore Black or African American Black People Carcinoma - epidemiology Carcinoma - genetics Carcinoma - pathology Genomics Genotype Humans Male Original Report Prostate - pathology Prostatic Neoplasms - epidemiology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology South Africa - epidemiology South Africa Baltimore
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Summary:	Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of CaP in SSA. We established the Men of African Descent and Carcinoma of the Prostate Network, which includes seven SSA centers partnering with five US centers to study the genetics and epidemiology of CaP in SSA. We developed common data elements and instruments, regulatory infrastructure, and biosample collection, processing, and shipping protocols. We tested this infrastructure by collecting epidemiologic, medical record, and genomic data from a total of 311 patients with CaP and 218 matched controls recruited at the seven SSA centers. We extracted genomic DNA from whole blood, buffy coat, or buccal swabs from 265 participants and shipped it to the Center for Inherited Disease Research (Baltimore, MD) and the Centre for Proteomics and Genomics Research (Cape Town, South Africa), where genotypes were generated using the UK Biobank Axiom Array. We used common instruments for data collection and entered data into the shared database. Double-entered data from pilot participants showed a 95% to 98% concordance rate, suggesting that data can be collected, entered, and stored with a high degree of accuracy. Genotypes were obtained from 95% of tested DNA samples (100% from blood-derived DNA samples) with high concordance across laboratories. We provide approaches that can produce high-quality epidemiologic and genomic data in multicenter studies of cancer in SSA.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2378-9506 2378-9506
DOI:	10.1200/JGO.18.00063