Search Results - "Aizpea, Zubia"

In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, Maria, Moutinho, Catia, Setien, Fernando, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Solvent-Free Thermal and Microwave-Assisted [3 + 2] Cycloadditions between Stabilized Azomethine Ylides and Nitrostyrenes. An Experimental and Theoretical Study by Arrieta, Ana, Otaegui, Dorleta, Zubia, Aizpea, Cossío, Fernando P, Díaz-Ortiz, Angel, de la Hoz, Antonio, Herrero, M. Antonia, Prieto, Pilar, Foces-Foces, Concepción, Pizarro, José L, Arriortua, María I

“…The stereochemical outcomes observed in the thermal and microwave-assisted [3 + 2] cycloaddition between stabilized azomethine ylides and nitrostyrenes have…”
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c-Met in pancreatic cancer stem cells： Therapeutic implications by Marta Herreros-Villanueva Aizpea Zubia-Olascoaga Luis Bujanda

“…Pancreatic cancer is the deadliest solid cancer and currently the fourth most frequent cause of cancer-related deaths. Emerging evidence suggests that cancer…”
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Development and validation of a liquid chromatography–tandem mass spectrometry for the determination of Kendine 91, a novel histone deacetylase inhibitor, in mice plasma and tissues: Application to a pharmacokinetic study by Otaegui, Dorleta, Rodríguez-Gascón, Alicia, Zubia, Aizpea, Cossío, Fernando P., Pedraz, José Luis

“…A liquid chromatography–tandem mass spectrometric method (LC–MS/MS) has been developed and validated to determine the concentration of Kendine 91 in mice…”
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Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice by Otaegui, Dorleta, Rodríguez-Gascón, Alicia, Zubia, Aizpea, Cossío, Fernando P, Pedraz, José Luis

“…Purpose The present investigation was undertaken to characterize the pharmacokinetics and oral bioavailability of Kendine 91 in mice and to compare it with…”
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Abstract 4725: Efficacy of a new small-molecule inhibitor of histone deacetylase 6 (HDAC6) in preclinical models of B-cell lymphoma and acute myeloid leukemia by Villanueva, Lorea, Perez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Setien, Fernando, Moutinho, Catia, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José Tomás, Piris, Miguel Ángel, Cossio, Fernando, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia by Perez-Salvia, Montserrat, Eneko, Aldaba, Yosu, Vara, Myriam, Fabre, Cristina, Ferrer, Carme, Masdeu, Aizpea, Zubia, Eider, San Sebastian, Dorleta, Otaegui, Pere, Llinàs-Arias, Margalida, Rosselló-Tortella, Maria, Berdasco, Fernando, Setien, Catia, Moutinho, Alberto, Villanueva, González-Barca, Eva, Muncunill, Josep, Navarro, Jose Tomas, Piris, Miguel Angel, Fernando, Cossio, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, San Sebastian, Eider, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Moutinho, Cátia, Setién, Fernando, Villanueva Garatachea, Alberto, González Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Design, Synthesis, and Functional Evaluation of Leukocyte Function Associated Antigen‑1 Antagonists in Early and Late Stages of Cancer Development by San Sebastián, Eider, Zimmerman, Tahl, Zubia, Aizpea, Vara, Yosu, Martin, Elyette, Sirockin, Finton, Dejaegere, Annick, Stote, Roland H, Lopez, Xabier, Pantoja-Uceda, David, Valcárcel, María, Mendoza, Lorea, Vidal-Vanaclocha, Fernando, Cossío, Fernando P, Blanco, Francisco J

“…The integrin leukocyte function associated antigen 1 (LFA-1) binds the intercellular adhesion molecule 1 (ICAM-1) by its αL-chain inserted domain (I-domain)…”
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Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of α4β1-Integrin-Mediated Hepatic Melanoma Metastasis by Zubia, Aizpea, Mendoza, Lorea, Vivanco, Silvia, Aldaba, Eneko, Carrascal, Teresa, Lecea, Begoña, Arrieta, Ana, Zimmerman, Tahl, Vidal-Vanaclocha, Fernando, Cossío, Fernando P.

“…Inhibitors of the interaction between protein VLA‐4 and its natural ligand VCAM‐1 have been designed, even though the structure of the protein remains…”
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Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study by Otaegui, Dorleta, Masdeu, Carme, Aldaba, Eneko, Vara, Yosu, Zubia, Aizpea, San Sebastian, Eider, Alcalá, Maria, Villafruela, Sergio, Cossío, Fernando P., Rodriguez-Gascón, Alicia

“…IKH12 is a novel histone deacetylase 6 selective inhibitor. A rapid and sensitive liquid chromatography tandem mass spectrometry method was developed and…”
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Abstract C46: Design, synthesis, and functional evaluation of leukocyte-function associated antigen-1 (LFA-1) antagonists in early and late stages of cancer development by Sebastin, Eider San, Zimmerman, Tahl, Zubia, Aizpea, Vara, Yosu, Martin, Elyette, Dejaegere, Annick, Stote, Roland H., Lopez, Xabier, Pantoja-Uceda, David, Valcarcel, Maria, Mendoza, Lorea, Vidal-Vanaclocha, Fernando, Cossio, Fernando P., Blanco, Francisco J.

“…The integrin Leukocyte Function-associated Antigen-1 (LFA-1) recognizes and binds the Intercellular Adhesion Molecule-1 (ICAM-1) by its L chain Inserted domain…”
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Quantitative Evaluation of the Catalytic Activity of Dendrimers with Only One Active Center at the Core:  Application to the Nitroaldol (Henry) Reaction by Zubia, Aizpea, Cossío, Fernando P, Morao, Iñaki, Rieumont, Marina, Lopez, Xabier

“…One reference tertiary amine and three families of structurally related trialkylamines and dendrimers have been synthesized, characterized, and studied by…”
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Application of stereocontrolled stepwise [3+2] cycloadditions to the preparation of inhibitors of alpha4beta1-integrin-mediated hepatic melanoma metastasis by Zubia, Aizpea, Mendoza, Lorea, Vivanco, Silvia, Aldaba, Eneko, Carrascal, Teresa, Lecea, Begoña, Arrieta, Ana, Zimmerman, Tahl, Vidal-Vanaclocha, Fernando, Cossio, Fernando P

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Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of α 4 β 1 ‐Integrin‐Mediated Hepatic Melanoma Metastasis by Zubia, Aizpea, Mendoza, Lorea, Vivanco, Silvia, Aldaba, Eneko, Carrascal, Teresa, Lecea, Begoña, Arrieta, Ana, Zimmerman, Tahl, Vidal‐Vanaclocha, Fernando, Cossío, Fernando P.

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Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of α 4 β 1 ‐Integrin‐Mediated Hepatic Melanoma Metastasis by Zubia, Aizpea, Mendoza, Lorea, Vivanco, Silvia, Aldaba, Eneko, Carrascal, Teresa, Lecea, Begoña, Arrieta, Ana, Zimmerman, Tahl, Vidal‐Vanaclocha, Fernando, Cossío, Fernando P.

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Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of α4β1-Integrin-Mediated Hepatic Melanoma Metastasis by Zubia, Aizpea, Mendoza, Lorea, Vivanco, Silvia, Aldaba, Eneko, Carrascal, Teresa, Lecea, Begoña, Arrieta, Ana, Zimmerman, Tahl, Vidal-Vanaclocha, Fernando, Cossío, Fernando P.

“…Inhibitoren der Wechselwirkung zwischen dem Protein VLA‐4 und seinem natürlichen Liganden VCAM‐1 wurden entwickelt, obwohl die Struktur des Proteins unbekannt…”
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