Search Results - "Aizenstein, Brian"

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases by Shokat, Kevan M, Apsel, Beth, Blair, Jimmy A, Gonzalez, Beatriz, Nazif, Tamim M, Feldman, Morri E, Aizenstein, Brian, Hoffman, Randy, Williams, Roger L, Knight, Zachary A

“…The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains…”
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Noninvasive Detection of Acute and Chronic Injuries in Human Renal Transplant by Elevation of Multiple Cytokines/Chemokines in Urine by HUAIZHONG HU, KWUN, Jean, AIZENSTEIN, Brian D, KNECHTLE, Stuart J

“…Injuries in kidney transplant is currently diagnosed by needle biopsy. A noninvasive test that sensitively detects these injuries would benefit the patients…”
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Elevation of CXCR3‐Binding Chemokines in Urine Indicates Acute Renal‐Allograft Dysfunction by Hu, Huaizhong, Aizenstein, Brian D., Puchalski, Alice, Burmania, Jeanine A., Hamawy, Majed M., Knechtle, Stuart J.

“…A noninvasive urinary test that diagnoses acute renal allograft dysfunction would benefit renal transplant patients. We aimed to develop a rapid urinary…”
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Characterization of Cytochrome P450 2D6 Alleles Using the Invader™ System by Matt Neville, Rebecca Selzer, Brian Aizenstein, Megan Maguire, Kirk Hogan, Robert Walton, Ken Welsh, Bruce Neri, Monika de Arruda

“…The cytochrome p450 (CYP) superfamily comprises enzymes that play an essential role in the transformation of medically relevant compounds. Accurate genotyping…”
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Inhibitor hijacking of Akt activation by Shokat, Kevan M, Okuzumi, Tatsuya, Fiedler, Dorothea, Zhang, Chao, Gray, Daniel C, Aizenstein, Brian, Hoffman, Randy

“…The kinase Akt plays a central role as a regulator of multiple growth factor input signals, thus making it an attractive anticancer drug target. A-443654 is an…”
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Abstract 712: Detection of lung cancer by assay of novel methylated DNA markers in plasma by Allawi, Hatim T., Giakoumopoulos, Maria, Flietner, Evan, Oliphant, Austin, Volkmann, Carla, Aizenstein, Brian, Sander, Tamara, Eckmayer, Drew, Strong, Ashley Poenitzsch, Gray, Melissa, Berger, Barry, Yab, Tracy, Taylor, William, Mahoney, Douglas, Kisiel, John B., Midthun, David E., Ahlquist, David A., Lidgard, Graham P.

“…Abstract Purpose: Lung cancer is the leading cause of cancer deaths worldwide. Most present symptomatically at late stage with high lethality. Early detection…”
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A methylated DNA marker panel for the sensitive detection of lung cancer in tissue by Giakoumopoulos, Maria, Sander, Tamara, Volkmann, Carla, Oliphant, Austin, Flietner, Evan, Aizenstein, Brian, Eckmayer, Drew, Vaccaro, Abram, Rathore, Vipul, Carlson, Jennifer, Berger, Barry M., Yab, Tracy C., Taylor, William R, Smyrk, Thomas C., Edell, Eric, Mahoney, Douglas W., Kisiel, John B., Ahlquist, David A., Lidgard, Graham P., Allawi, Hatim T.

“…Abstract only…”
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Synthesis and evaluation of indazole based analog sensitive Akt inhibitors by Okuzumi, Tatsuya, Ducker, Gregory S, Zhang, Chao, Aizenstein, Brian, Hoffman, Randy, Shokat, Kevan M

“…The kinase Akt is a key signaling node in regulating cellular growth and survival. It is implicated in cancer by mutation and its role in the downstream…”
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Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs by Williams, Olusegun, Houseman, Benjamin T., Kunkel, Eric J., Aizenstein, Brian, Hoffman, Randy, Knight, Zachary A., Shokat, Kevan M.

“…PI3Kδ and PI3Kγ regulate immune cell signaling, while the related PI3Kα and PI3Kβ regulate cell survival and metabolism. Selective inhibitors of PI3Kδ/γ…”
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Characterization of cytochrome P450 2D6 alleles using the Invader system by Nevilie, Matt, Selzer, Rebecca, Aizenstein, Brian, Maguire, Megan, Hogan, Kirk, Walton, Robert, Welsh, Ken, Neri, Bruce, de Arruda, Monika

“…The cytochrome p450 (CYP) superfamily comprises enzymes that play an essential role in the transformation of medically relevant compounds. Accurate genotyping…”
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Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs by Williams, Olusegun, Houseman, Benjamin T, Kunkel, Eric J, Aizenstein, Brian, Hoffman, Randy, Knight, Zachary A, Shokat, Kevan M

“…PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of…”
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Variable and conserved structural elements of trypanosome variant surface glycoproteins by Reinitz, D M, Aizenstein, B D, Mansfield, J M

“…The characterization of B cell epitopes on the trypanosome variant surface glycoprotein (VSG) rests on elucidation of variant specific amino acid sequences…”
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