Search Results - "Aizawa, Yuuki"
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A loop extrusion-independent mechanism contributes to condensin I-mediated chromosome shaping
Published in The Journal of cell biology (07-03-2022)“…Condensin I is a five-subunit protein complex that is central to mitotic chromosome assembly in eukaryotic cells. Despite recent progress, its molecular…”
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Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays
Published in eLife (19-08-2022)“…In vertebrates, condensin I and condensin II cooperate to assemble rod-shaped chromosomes during mitosis. Although the mechanism of action and regulation of…”
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Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma
Published in Laboratory investigation (01-03-2020)“…Cancer cells, including malignant lymphoma cells, alter their metabolism, termed “metabolic reprograming,” on initiation of malignant transformation as well as…”
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Survival prognostic factors in nonsmall cell lung cancer patients with simultaneous brain metastases and poor performance status at initial presentation
Published in Heliyon (30-09-2024)“…Although the treatment of nonsmall cell lung cancer (NSCLC) has rapidly progressed recently, there is little evidence of treatment for patients with…”
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Improved Methods for Preparing the Telomere Tethering Complex Bqt1–Bqt2 for Structural Studies
Published in The Protein Journal (01-04-2020)“…In eukaryotes, chromosome ends (telomeres) are tethered to the inner nuclear membrane. During the early stages of meiosis, telomeres move along the nuclear…”
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Regulation of condensin II by self-suppression and release mechanisms
Published in Molecular biology of the cell (01-02-2024)“…In vertebrates, two distinct condensin complexes, condensin I and condensin II, cooperate to drive mitotic chromosome assembly. It remains largely unknown how…”
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