Search Results - "Aizawa, Kazumasa"

Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis by Takata, Toshihiko, Shimizu, Atsuyuki, Sakakibara, Shiro, Watabe, Hiroomi, Aizawa, Kazumasa, Totsuka, Kyoichi

“…Pharmacokinetic and pharmacodynamic (PK/PD) parameters, which are important indices of the therapeutic efficacy of antimicrobials, and the minimum inhibitory…”
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Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers by Nakashima, Mitsuyoshi, Morita, Jun, Takata, Toshihiko, Aizawa, Kazumasa

“…Tebipenem pivoxil (TBPM-PI), a novel oral carbapenem antibiotic, is a prodrug of tebipenem (TBPM). We assessed the pharmacokinetics of TBPM-PI fine granules at…”
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Tissue and aural discharge distribution of tebipenem pivoxil by Baba, Shunkichi, Kasahara, Hiroshi, Morita, Jun, Aizawa, Kazumasa, Sunakawa, Keisuke

“…Tebipenem pivoxil (TBPM-PI) is a novel oral carbapenem antibiotic. It has been developed as a prodrug of tebipenem (TBPM), to increase absorption. We assessed…”
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Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin by Cahalan, M K, Hashimoto, Y, Aizawa, K, Verotta, D, Ionescu, P, Balea, M, Eger, 2nd, E I, Benet, L Z, Ehrenfeld, W K, Goldstone, J

“…There is no adequate explanation for the highly variable response of systemic blood pressure to nitroglycerin (glyceryl trinitrate [GTN]). Aging produces…”
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Physiological models are good tools to predict rat bioavailability of EF5154 prodrugs from in vitro intestinal parameters by Nomoto, Masahiro, Tatebayashi, Tomoko, Morita, Jun, Suzuki, Hisashi, Aizawa, Kazumasa, Kurosawa, Tohru, Komiya, Izumi

“…There are only a few reports on the methods that predict in vivo bioavailability from in vitro intestinal parameters. In the present study, we constructed…”
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PHARMACOKINETICS OF ME 1207, A NOVEL ORAL CEPHEM ANTIBIOTIC, IN EXPERIMENTAL ANIMALS by Matsumoto, Takashi, Okamoto, Junichi, Saito, Kouichi, Aizawa, Kazumasa, Komiya, Izumi

“…The pharmacokinetics of ME 1207, a new oral cephem antibiotic, was studied in mice, rats and dogs. 1. ME 1207 was mainly absorbed from the upper part of the…”
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Report 2 : POINTS TO BE CONSIDERED FOR CONDUCTING TOXICOKINETIC STUDIES UNDER GLP AND FOR VALIDATING ANALYTICAL METHODS (<Session 5A>TOXICOKINETICS) by YUZURIHA, Teruaki, AIZAWA, Kazumasa, OKADA, Junya

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イヌ及びヒトにおけるEthyl Loflazepate (CM6912) 代謝物の生体内動態コンピューターによるシミュレーション by 伊藤, 雅之, 相沢, 一雅, 小宮, 泉, 宮城, 克己, 藤田, 正敬, 梅村, 甲子郎

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Points to be considered for conducting toxicokinetic studies under GLP and for validating analytical methods by Yuzuriha, T, Aizawa, K, Okada, J

“…Issues discussed by TK Working Group of the JPMA for the implementation of ICH guideline for toxicokinetics (TK) are summarized. 1) A unique management system…”
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Dose- and time-dependent kinetics of the renal excretion of nitrofurantoin in the rabbit by Watari, N, Aizawa, K, Kaneniwa, N

“…A pharmacokinetic study on the renal excretion of nitrofurantoin was carried out in rabbits at doses ranging from 0.5 to 15 mg/kg. With increasing dose,…”
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Nonlinear assessment of nitrofurantoin bioavailability in rabbits by Watari, N, Funaki, T, Aizawa, K, Kaneniwa, N

“…The influence of route of administration on the absolute bioavailability and GI tract absorption of nitrofurantoin was investigated in rabbits. The disposition…”
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Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes by Hale, V G, Aizawa, K, Sheiner, L B, Benet, L Z

“…The livers of 15 rabbits were perfused in situ with prednisone (PO) or prednisolone (POH) over a wide range of steady state concentrations, resulting in…”
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Pharmacokinetics of the Two Major Metabolites of Ethyl Loflazepate (CM6912) in Dogs and Humans. Simulation by a Digital Computer by ITO, MASAYUKI, AIZAWA, KAZUMASA, KOMIYA, IZUMI, MIYAGI, KATSUMI, FUJITA, MASATAKA, UMEMURA, KOSHIRO

“…A linear pharmacokinetic model was developed in order to calculate separately the plasma (or blood) concentrations of CM6913 and CM7116, major metabolites of…”
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