Search Results - "Aiyar, Nambi V"

Differential vasoconstrictor activity of human urotensin‐II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey by Douglas, Stephen A, Sulpizio, Anthony C, Piercy, Valerie, Sarau, Henry M, Ames, Robert S, Aiyar, Nambi V, Ohlstein, Eliot H, Willette, Robert N

“…Urotensin‐II (U‐II) and its G‐protein‐coupled receptor, GPR14, are expressed within mammalian cardiac and peripheral vascular tissue and, as such, may regulate…”
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Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats by Wang, X, Barone, F C, Aiyar, N V, Feuerstein, G Z

“…The expression of interleukin-1 beta (IL-1 beta) is upregulated after focal brain ischemia, and previous work has demonstrated its involvement in ischemic…”
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Characterization of neuromedin U effects in canine smooth muscle by Westfall, Timothy D, McCafferty, Gerald P, Pullen, Mark, Gruver, Susan, Sulpizio, Anthony C, Aiyar, V Nambi, Disa, Jyoti, Contino, Lisa C, Mannan, Ishrat J, Hieble, J Paul

“…Two endogenous receptors for the potent smooth muscle-stimulating peptide neuromedin U (NmU) have recently been identified and cloned. Pharmacological,…”
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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 by Ames, Robert S, Sarau, Henry M, Chambers, Johathan K, Willette, Robert N, Aiyar, Nambi V, Romanic, Anne M, Louden, Calvert S, Foley, James J, Sauermelch, Charles F, Coatney, Robert W, Ao, Zhaohui, Disa, Jyoti, Holmes, Stephen D, Stadel, Jeffrey M, Martin, John D, Liu, Wu-Schyong, Glover, George I, Wilson, Shelagh, McNulty, Dean E, Ellis, Catherine E, Elshourbagy, Nabil A, Shabon, Usman, Trill, John J, Hay, Douglas W. P, Ohlstein, Eliot H, Bergsma, Derk J, Douglas, Stephen A

“…Urotensin-II (U-II) is a vasoactive 'somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned…”
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Molecular and pharmacological characterization of genes encoding urotensin‐II peptides and their cognate G‐protein‐coupled receptors from the mouse and monkey by Elshourbagy, Nabil A., Douglas, Stephen A., Shabon, Usman, Harrison, Stephen, Duddy, Graham, Sechler, Jan L., Ao, Zhaohui, Maleeff, Beverly E., Naselsky, Diane, Disa, Jyoti, Aiyar, Nambi V.

“…Urotensin‐II (U‐II) and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases. To test such hypothesis,…”
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Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists by MORALES-RAMOS, Angel I, MECOM, John S, LONDREGAN, Allyn T, MORROW, Dwight M, SENADHI, Shobha, THALJI, Reema K, ZHAO, Steve, BURNS-KURTIS, Cynthia L, MARINO, Joseph P, KIESOW, Terry J, GRAYBILL, Todd L, BROWN, Gregory D, AIYAR, Nambi V, DAVENPORT, Elizabeth A, KALLAL, Lorena A, KNAPP-REED, Beth A, PENG LI

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Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists by Morales-Ramos, Angel I, Mecom, John S, Kiesow, Terry J, Graybill, Todd L, Brown, Gregory D, Aiyar, Nambi V, Davenport, Elizabeth A, Kallal, Lorena A, Knapp-Reed, Beth A, Li, Peng, Londregan, Allyn T, Morrow, Dwight M, Senadhi, Shobha, Thalji, Reema K, Zhao, Steve, Burns-Kurtis, Cynthia L, Marino, Jr, Joseph P

“…High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists…”
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The peptidic urotensin‐II receptor ligand GSK248451 possesses less intrinsic activity than the low‐efficacy partial agonists SB‐710411 and urantide in native mammalian tissues and recombinant cell systems by Behm, David J, Stankus, Gerald, Doe, Christopher P A, Willette, Robert N, Sarau, Henry M, Foley, James J, Schmidt, Dulcie B, Nuthulaganti, Parvathi, Fornwald, James A, Ames, Robert S, Lambert, David G, Calo', Girolamo, Camarda, Valeria, Aiyar, Nambi V, Douglas, Stephen A

“…1 Several peptidic urotensin‐II (UT) receptor antagonists exert ‘paradoxical’ agonist activity in recombinant cell‐ and tissue‐based bioassay systems, likely…”
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Identification and pharmacological characterization of native, functional human urotensin‐II receptors in rhabdomyosarcoma cell lines by Douglas, Stephen A, Naselsky, Diane, Ao, Zhaohui, Disa, Jyoti, Herold, Christopher L, Lynch, Frank, Aiyar, Nambi V

“…In an effort to identify endogenous, native mammalian urotensin‐II (U‐II) receptors (UT), a diverse range of human, primate and rodent cell lines (49 in total)…”
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Identification and characterization of binding sites for human urotensin-II in Sprague–Dawley rat renal medulla using quantitative receptor autoradiography by Disa, Jyoti, Floyd, Latitia E., Edwards, Richard M., Douglas, Stephen A., Aiyar, Nambi V.

“…Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date…”
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erratum: Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 by Ames, Robert S, Sarau, Henry M, Chambers, Johathan K, Willette, Robert N, Aiyar, Nambi V, Romanic, Anne M, Louden, Calvert S, Foley, James J, Sauermelch, Charles F, Coatney, Robert W, Ao, Zhaohui, Disa, Jyoti, Holmes, Stephen D, Stadel, Jeffrey M, Martin, John D, Liu, Wu-Schyong, Glover, George I, Wilson, Shelagh, McNulty, Dean E, Ellis, Catherine E, Elshourbagy, Nabil A, Shabon, Usman, Trill, John J, Hay, Douglas W. P, Ohlstein, Eliot H, Bergsma, Derk J, Douglas, Stephen A

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Development of potent and selective small-molecule human Urotensin-II antagonists by McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Sehon, Clark A., Sha, Deyou, Wang, Gren Z., Wang, Ning, Viet, Andrew Q., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Yuan, Catherine C.K., Douglas, Stephen A., Neeb, Michael J.

“…This work describes the development of potent and selective human Urotensin-II antagonists starting from lead compound 1. Several problems relating to oral…”
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Differential agonistic and antagonistic effects of the urotensin-II ligand SB-710411 at rodent and primate UT receptors by BEHM, David J, HEROLD, Christopher L, CAMARDA, Valeria, AIYAR, Nambi V, DOUGLAS, Stephen A

“…SB-710411 (Cpa-c[d-Cys-Pal-d-Trp-Lys-Val-Cys]-Cpa-amide) inhibited [(125)I]urotensin-II rat and monkey UT receptor binding (pK(i)s 7.50+/-0.07 and…”
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Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles by McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Erhard, Karl, Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Jin, Jian, Sehon, Clark A., Sha, Deyou, Shi, Dongchuan, Wang, Feng, Wang, Gren Z., Wang, Ning, Wang, Yonghui, Viet, Andrew Q., Yuan, Catherine C.K., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Douglas, Stephen A., Neeb, Michael J.

“…Redesign of the potent human urotensin-II antagonist 1 with the 2-pyrrolidinylmethyl-3-phenyl-piperidine core to a new chemical series with a substituted…”
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Inhibitory effects of putative peptidic urotensin-II receptor antagonists on urotensin-II-induced contraction of cat isolated respiratory smooth muscle by Behm, David J., Ao, Zhaohui, Camarda, Valeria, Aiyar, Nambi V., Johns, Douglas G., Douglas, Stephen A.

“…Urotensin-II is purported to influence pulmonary function by modulating smooth muscle tone/growth. In the present study, Northern blot and reverse…”
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Human Urotensin-II is a Potent Vasoactive Peptide: Pharmacological Characterization in the Rat, Mouse, Dog and Primate by Douglas, Stephen A, Ashton, Daryl J, Sauermelch, Charles F, Coatney, Robert W, Ohlstein, Derek H, Ruffolo, Michael R, Ohlstein, Eliot H, Aiyar, Nambi V, Willette, Robert N

“…The observation that the novel G-protein-coupled receptor (GPCR) GPR14 and its cognate ligand, urotensin-II (U-II), are expressed within the mammalian…”
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Human Urotensin-II is a Potent Vasoactive Peptide: Pharmacological Characterization in the Rat, Mouse, Dog and Primate by Douglas, Stephen A, Ashton, Daryl J, Sauermelch, Charles F, Coatney, Robert W, Ohlstein, Derek H, Ruffolo, Michael R, Ohlstein, Eliot H, Aiyar, Nambi V, Willette, Robert N

“…The observation that the novel G-protein-coupled receptor (GPCR) GPR14 and its cognate ligand, urotensin-II (U-II), are expressed within the mammalian…”
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Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375 by Douglas, Stephen A, Behm, David J, Aiyar, Nambi V, Naselsky, Diane, Disa, Jyoti, Brooks, David P, Ohlstein, Eliot H, Gleason, John G, Sarau, Henry M, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Wixted, William E, Widdowson, Katherine, Riley, Graham, Jin, Jian, Gallagher, Timothy F, Schmidt, Stanley J, Ridgers, Lance, Christmann, Lisa T, Keenan, Richard M, Knight, Steven D, Dhanak, Dashyant

“…1 SB‐706375 potently inhibited [125I]hU‐II binding to both mammalian recombinant and ‘native’ UT receptors (Ki 4.7±1.5 to 20.7±3.6 nM at rodent, feline and…”
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Tetrahydro-4-quinolinamines identified as novel P2Y sub(1) receptor antagonists by Morales-Ramos, Angel I, Mecom, John S, Kiesow, Terry J, Graybill, Todd L, Brown, Gregory D, Aiyar, Nambi V, Davenport, Elizabeth A, Kallal, Lorena A, Knapp-Reed, Beth A, Li, Peng, Londregan, Allyn T, Morrow, Dwight M, Senadhi, Shobha, Thalji, Reema K, Zhao, Steve, Burns-Kurtis, Cynthia L, Marino, Joseph P

“…High-throughput screening of the GSK compound collection against the P2Y sub(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists…”
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Discovery of Adrenomedullin in Rat Ischemic Cortex and Evidence for its Role in Exacerbating Focal Brain Ischemic Damage by Wang, Xinkang, Yue, Tian-Li, Barone, Frank C., White, Raymond F., Clark, Robert K., Willette, Robert N., Sulpizio, Antony C., Aiyar, Nambi V., Ruffolo, Robert R., Feuerstein, Giora Z.

“…Focal brain ischemia is the most common event leading to stroke in humans. To understand the molecular mechanisms associated with brain ischemia, we applied…”
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