Search Results - "Aiyar, NV"

Differential vasoconstrictor activity of human urotensin‐II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey by Douglas, Stephen A, Sulpizio, Anthony C, Piercy, Valerie, Sarau, Henry M, Ames, Robert S, Aiyar, Nambi V, Ohlstein, Eliot H, Willette, Robert N

“…Urotensin‐II (U‐II) and its G‐protein‐coupled receptor, GPR14, are expressed within mammalian cardiac and peripheral vascular tissue and, as such, may regulate…”
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Molecular and pharmacological characterization of genes encoding urotensin‐II peptides and their cognate G‐protein‐coupled receptors from the mouse and monkey by Elshourbagy, Nabil A., Douglas, Stephen A., Shabon, Usman, Harrison, Stephen, Duddy, Graham, Sechler, Jan L., Ao, Zhaohui, Maleeff, Beverly E., Naselsky, Diane, Disa, Jyoti, Aiyar, Nambi V.

“…Urotensin‐II (U‐II) and its receptor (UT) represent novel therapeutic targets for management of a variety of cardiovascular diseases. To test such hypothesis,…”
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GSK1562590, a slowly dissociating urotensin‐II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo by Behm, DJ, Aiyar, NV, Olzinski, AR, McAtee, JJ, Hilfiker, MA, Dodson, JW, Dowdell, SE, Wang, GZ, Goodman, KB, Sehon, CA, Harpel, MR, Willette, RN, Neeb, MJ, Leach, CA, Douglas, SA

“…BACKGROUND AND PURPOSE Recently identified antagonists of the urotensin–II (U‐II) receptor (UT) are of limited utility for investigating the…”
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Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375 by Douglas, Stephen A, Behm, David J, Aiyar, Nambi V, Naselsky, Diane, Disa, Jyoti, Brooks, David P, Ohlstein, Eliot H, Gleason, John G, Sarau, Henry M, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Wixted, William E, Widdowson, Katherine, Riley, Graham, Jin, Jian, Gallagher, Timothy F, Schmidt, Stanley J, Ridgers, Lance, Christmann, Lisa T, Keenan, Richard M, Knight, Steven D, Dhanak, Dashyant

“…1 SB‐706375 potently inhibited [125I]hU‐II binding to both mammalian recombinant and ‘native’ UT receptors (Ki 4.7±1.5 to 20.7±3.6 nM at rodent, feline and…”
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Identification and pharmacological characterization of native, functional human urotensin‐II receptors in rhabdomyosarcoma cell lines by Douglas, Stephen A, Naselsky, Diane, Ao, Zhaohui, Disa, Jyoti, Herold, Christopher L, Lynch, Frank, Aiyar, Nambi V

“…In an effort to identify endogenous, native mammalian urotensin‐II (U‐II) receptors (UT), a diverse range of human, primate and rodent cell lines (49 in total)…”
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Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats by Wang, X, Barone, F C, Aiyar, N V, Feuerstein, G Z

“…The expression of interleukin-1 beta (IL-1 beta) is upregulated after focal brain ischemia, and previous work has demonstrated its involvement in ischemic…”
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Discovery of Adrenomedullin in Rat Ischemic Cortex and Evidence for its Role in Exacerbating Focal Brain Ischemic Damage by Wang, Xinkang, Yue, Tian-Li, Barone, Frank C., White, Raymond F., Clark, Robert K., Willette, Robert N., Sulpizio, Antony C., Aiyar, Nambi V., Ruffolo, Robert R., Feuerstein, Giora Z.

“…Focal brain ischemia is the most common event leading to stroke in humans. To understand the molecular mechanisms associated with brain ischemia, we applied…”
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Differential agonistic and antagonistic effects of the urotensin-II ligand SB-710411 at rodent and primate UT receptors by BEHM, David J, HEROLD, Christopher L, CAMARDA, Valeria, AIYAR, Nambi V, DOUGLAS, Stephen A

“…SB-710411 (Cpa-c[d-Cys-Pal-d-Trp-Lys-Val-Cys]-Cpa-amide) inhibited [(125)I]urotensin-II rat and monkey UT receptor binding (pK(i)s 7.50+/-0.07 and…”
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Inhibitory effects of putative peptidic urotensin-II receptor antagonists on urotensin-II-induced contraction of cat isolated respiratory smooth muscle by Behm, David J., Ao, Zhaohui, Camarda, Valeria, Aiyar, Nambi V., Johns, Douglas G., Douglas, Stephen A.

“…Urotensin-II is purported to influence pulmonary function by modulating smooth muscle tone/growth. In the present study, Northern blot and reverse…”
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Human Urotensin-II is a Potent Vasoactive Peptide: Pharmacological Characterization in the Rat, Mouse, Dog and Primate by Douglas, Stephen A, Ashton, Daryl J, Sauermelch, Charles F, Coatney, Robert W, Ohlstein, Derek H, Ruffolo, Michael R, Ohlstein, Eliot H, Aiyar, Nambi V, Willette, Robert N

“…The observation that the novel G-protein-coupled receptor (GPCR) GPR14 and its cognate ligand, urotensin-II (U-II), are expressed within the mammalian…”
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Adrenocorticotropin-dependent particulate guanylate cyclase in rat adrenal and adrenocortical carcinoma: comparison of its properties with soluble guanylate cyclase and its relationship with ACTH-induced steroidogenesis by Nambi, P, Aiyar, N V, Sharma, R K

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Relationship of calcium and membrane guanylate cyclase in adrenocorticotropin-induced steroidogenesis by Nambi, P, Aiyar, N V, Roberts, A N, Sharma, R K

“…Chlorpromazine, when incubated with isolated adrenal cells, inhibited the ACTH-stimulated formation of cGMP and corticosterone production. It also inhibited…”
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Solubilization of epinephrine-specific α 2-adrenergic receptors from adrenocortical carcinoma by Nambi, Ponnal, Aiyar, Nambi V., Sharma, Rameshwar K.

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Production and characterization of monoclonal antibodies against the vasoconstrictive peptide human urotensin-II by Su, Jui-Lan, Ao, Zhaohui, Aiyar, Nambi V, Ellis, Byron, Martin, John D, Douglas, Stephen A, Kull, Jr, Frederick C

“…We report the production and characterization of four monoclonal antibodies (MAbs) against human urotensin-II (hU-II). The antibodies were raised against human…”
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