Search Results - "Aitken, M. R."

Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making by Clark, L., Bechara, A., Damasio, H., Aitken, M. R. F., Sahakian, B. J., Robbins, T. W.

“…The ventromedial prefrontal cortex (vmPFC) and insular cortex are implicated in distributed neural circuitry that supports emotional decision-making. Previous…”
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Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides by Radakovic, Aleksandar, DasGupta, Saurja, Wright, Tom H, Aitken, Harry R M, Szostak, Jack W

“…Aminoacylated transfer RNAs, which harbor a covalent linkage between amino acids and RNA, are a universally conserved feature of life. Because they are…”
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Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions by Corlett, P.R., Murray, G.K., Honey, G.D., Aitken, M.R.F., Shanks, D.R., Robbins, T.W., Bullmore, E.T., Dickinson, A., Fletcher, P.C.

“…Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error—a mismatch between expectancy and outcome—drives…”
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Associations and propositions: The case for a dual-process account of learning in humans by McLaren, I.P.L., Forrest, C.L.D., McLaren, R.P., Jones, F.W., Aitken, M.R.F., Mackintosh, N.J.

“…We review evidence that supports the conclusion that people can and do learn in two distinct ways – one associative, the other propositional. No one disputes…”
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Synthesis of the C4–C16 Polyketide Fragment of Portimines A and B by Ding, Xiao-Bo, Aitken, Harry R. M, Pearl, Esperanza S, Furkert, Daniel P, Brimble, Margaret A

“…Stereoselective synthesis of the C4–C16 polyketide fragment of portimines A and B is reported, enabled by our previously established method for the…”
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Striatal sensitivity to personal responsibility in a regret-based decision-making task by Camille, N., Pironti, V. A., Dodds, C. M., Aitken, M. R. F., Robbins, T. W., Clark, L.

“…Regret and relief are complex emotional states associated with the counterfactual processing of nonobtained outcomes in a decision-making situation. In the…”
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Intermolecular Diels–Alder Cycloaddition/Cross-Coupling Sequences of 2‑Bromo-1,3-butadienes by Choi, Hans, Shirley, Harry J, Aitken, Harry R. M, Schulte, Tim, Söhnel, Tilo, Hume, Paul A, Brimble, Margaret A, Furkert, Daniel P

“…2-Bromo-1,3-butadienes are demonstrated to be effective substrates for tandem Diels–Alder/transition metal cross-coupling reaction sequences. Intermolecular…”
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Diazepam produces disinhibitory cognitive effects in male volunteers by DEAKIN, J. B, AITKEN, M. R. F, DOWSON, J. H, ROBBINS, T. W, SAHAKIAN, B. J

“…Diazepam has well known amnestic and sedative effects but effects on fronto-executive function remain largely uninvestigated, especially on…”
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Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary by Aitken, Harry R M, Furkert, Daniel P, Hubert, Jonathan G, Wood, James M, Brimble, Margaret A

“…This article describes our efforts to develop an asymmetric synthesis of bisbenzannulated spiroketals using a chiral sulfoxide auxiliary. Our primary focus was…”
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Assessing gastrointestinal motility in healthy horses comparing auscultation, ultrasonography and an acoustic gastrointestinal surveillance biosensor: a randomised, blinded, controlled crossover proof of principle study by VanderBroek, A. R., Reef, V. B., Aitken, M. R., Stefanovski, D., Southwood, L. L.

“…Summary Background Auscultation and ultrasonography are noninvasive techniques used to assess gastrointestinal motility in horses. Recently, noninvasive…”
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Small-Molecule Organocatalysis Facilitates In Situ Nucleotide Activation and RNA Copying by Aitken, Harry R. M., Wright, Tom H., Radakovic, Aleksandar, Szostak, Jack W.

“…A key challenge in origin-of-life research is the identification of plausible conditions that facilitate multiple steps along the pathway from chemistry to…”
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Overcoming nucleotide bias in the nonenzymatic copying of RNA templates by Duzdevich, Daniel, Carr, Christopher E, Colville, Ben W F, Aitken, Harry R M, Szostak, Jack W

“…Abstract The RNA World hypothesis posits that RNA was the molecule of both heredity and function during the emergence of life. This hypothesis implies that RNA…”
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A potential role for RNA aminoacylation prior to its role in peptide synthesis by Radakovic, Aleksandar, Lewicka, Anna, Todisco, Marco, Aitken, Harry R M, Weiss, Zoe, Kim, Shannon, Bannan, Abdullah, Piccirilli, Joseph A, Szostak, Jack W

“…Coded ribosomal peptide synthesis could not have evolved unless its sequence and amino acid-specific aminoacylated tRNA substrates already existed. We…”
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Small colon stenosis secondary to ulcerative colitis in three Standardbred foals by Kopper, J., Stewart, S., Habecker, P., Aitken, M. R., Southwood, L. L.

“…Summary Three Standardbred foals, a colt approximately one month old and 2 fillies approximately 4.5 months old, from the same farm, presented to University of…”
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Stimulus-Outcome Interactions During Instrumental Discrimination Learning by Rats and Humans by de Wit, S, Niry, D, Wariyar, R, Aitken, M. R. F, Dickinson, A

“…The associative structure mediating goal-directed action was investigated using congruent and incongruent conditional discriminations. The stimulus was the…”
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Structure–Activity Relationships in Nonenzymatic Template‐Directed RNA Synthesis by Giurgiu, Constantin, Fang, Ziyuan, Aitken, Harry R. M., Kim, Seohyun Chris, Pazienza, Lydia, Mittal, Shriyaa, Szostak, Jack W.

“…The template‐directed synthesis of RNA played an important role in the transition from prebiotic chemistry to the beginnings of RNA based life, but the…”
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Structure–Activity Relationships in Nonenzymatic Template‐Directed RNA Synthesis by Giurgiu, Constantin, Fang, Ziyuan, Aitken, Harry R. M., Kim, Seohyun Chris, Pazienza, Lydia, Mittal, Shriyaa, Szostak, Jack W.

“…The template‐directed synthesis of RNA played an important role in the transition from prebiotic chemistry to the beginnings of RNA based life, but the…”
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Perceptual Differentiation During Categorization Learning by Pigeons by Aitken, M. R. F, Bennett, C. H, McLaren, I. P. L, Mackintosh, N. J

“…In Experiment 1, pigeons were trained to categorize two sets of variable stimuli (black and white checkerboard patterns), constructed by random distortions of…”
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Small colon stenosis secondary to ulcerative colitis in three S tandardbred foals by Kopper, J., Stewart, S., Habecker, P., Aitken, M. R., Southwood, L. L.

“…Summary Three S tandardbred foals, a colt approximately one month old and 2 fillies approximately 4.5 months old, from the same farm, presented to U niversity…”
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The effect of thymic inoculation to induce tolerance of allogeneic thyroid grafts in the outbred rabbit by Torchia, M G, Aitken, R M, Thliveris, A

“…Many studies have demonstrated that allograft tolerance can be achieved in inbred rats and mice following intrathymic injection of donor cells or antigen and…”
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