Search Results - "Aitio, M L"

Cytochrome P‐450 Isozyme Pattern Is Related to Individual Susceptibility to Diethylnitrosamine‐induced Liver Cancer in Rats by Aitio, Antero, Aitio, Mirja‐Liisa, Camus, Anne‐Marie, Cardis, Elisabeth, Bartsch, Helmut

“…Differences in susceptibility to chemical carcinogenesis between rodent strains and species have been linked to variations in genetically‐determined mixed…”
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The effect of enzyme induction on the metabolism of disopyramide in man by Aitio, ML, Mansury, L, Tala, E, Haataja, M, Aitio, A

“…1 The effects of rifampicin, phenytoin, and disopyramide treatments on the metabolism of disopyramide were studied in patients and volunteers. 2 Rifampicin…”
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Disopyramide concentrations in saliva by Aitio, M L, Virtanen, R, Lammintausta, R

“…The saliva and plasma concentrations of disopyramide and its main metabolite, mono-N-dealkyldisopyramide, and the protein binding of disopyramide were studied…”
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Disopyramide by Aitio, M L

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The pharmacokinetics of disopyramide and mono-N-dealkyl-disopyramide in humans by Aitio, M L, Allonen, H, Kanto, J, Mäntylä, R

“…The pharmacokinetics of disopyramide and its metabolite mono-N-dealkyl-disopyramide (MND) were studied after a single oral and intramuscular dose and at steady…”
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Evaluation of sister chromatid exchange as an indicator of sensitivity to N-ethyl-N-nitrosourea-induced carcinogenesis in rats by Aitio, A, Cabral, J R, Camus, A M, Galendo, D, Bartsch, H, Aitio, M L, Norppa, H, Salomaa, S, Sorsa, M, Husgafvel-Pursiainen, K

“…Sister chromatid exchange (SCE) frequencies in peripheral lymphocytes are a frequently used endpoint to indicate exposures to genotoxins in groups of humans…”
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Induction of disopyramide N-dealkylation by phenobarbital and disopyramide in rat liver by Aitio, M L, Aitio, A

“…An in vitro assay for the determination of the activity of disopyramide-N-dealkylation was developed. This reaction was concluded to be catalyzed by the liver…”
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Plasma concentrations and protein binding of disopyramide and mono‐N‐ dealkyldisopyramide during chronic oral disopyramide therapy by Aitio, ML

“…1 The plasma levels of disopyramide and mono‐N‐dealkyldisopyramide were measured from 118 patients, and the protein binding of both drugs from 50 patients…”
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N‐acetylcysteine – passe‐partout or much ado about nothing? by Aitio, Mirja‐Liisa

“…In experimental studies, the old mucolytic agent N‐acetylcysteine (NAC) has had beneficial effects in disorders supposedly linked to oxidative stress…”
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Enhanced metabolism and diminished efficacy of disopyramide by enzyme induction? by Aitio, ML, Vuorenmaa, T.

“…1 Monitoring plasma levels of mono‐N‐dealkyldisopyramide (MND), the most important metabolite of disopyramide, has been considered unnecessary. 2 We measured…”
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Simultaneous determination of disopyramide and its mono-N-dealkylated metabolite in plasma by gas-liquid chromatography by Aitio, M L

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Characterization of the carcinoembryonic antigen activity associated with cyst fluids of mucinous ovarian cystadenocarcinoma by Yamashita, K, Aitio, M L, Dawson, J R

“…Cyst fluids from mucinous cystadenocarcinoma of the ovary show significant concentrations of carcinoembryonic antigen (CEA) activity. This CEA activity was…”
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Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital by Aitio, M L, Hietanen, E, Béréziat, J C, Arvela, P, Bartsch, H

“…The metabolism of R- and S-warfarin in vivo and in vitro, bufuralol in vitro, and antipyrine and debrisoquine in vivo were studied in rats with cancer induced…”
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The electrophoretic heterogeneity of carcinoembryonic antigen: An immunochemical analysis by Aitio, Mirja-Liisa, Yamashita, Kohki, Dawson, Jeffrey R.

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Is it possible to prevent kidney problems caused by immunosuppression? by Aitio, M L

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Protecting kidneys from radiocontrast toxicity--do fluids or drugs help? by Aitio, M L

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Measuring the kidney function in drug trials and during drug therapy by Aitio, M L

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Analgesics and kidney by Aitio, M L

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What a physician ought to know about lithium therapy by Aitio, M L

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Pharmacological prevention and treatment of diabetic nephropathy by Aitio, M L

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