Search Results - "Aitchison, K"

Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms by Uher, R, Perlis, R H, Henigsberg, N, Zobel, A, Rietschel, M, Mors, O, Hauser, J, Dernovsek, M Z, Souery, D, Bajs, M, Maier, W, Aitchison, K J, Farmer, A, McGuffin, P

“…Symptom dimensions have not yet been comprehensively tested as predictors of the substantial heterogeneity in outcomes of antidepressant treatment in major…”
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Measuring depression: comparison and integration of three scales in the GENDEP study by Uher, R, Farmer, A, Maier, W, Rietschel, M, Hauser, J, Marusic, A, Mors, O, Elkin, A, Williamson, R J, Schmael, C, Henigsberg, N, Perez, J, Mendlewicz, J, Janzing, J G E, Zobel, A, Skibinska, M, Kozel, D, Stamp, A S, Bajs, M, Placentino, A, Barreto, M, McGuffin, P, Aitchison, K J

“…A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and…”
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Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-α and ribavirin treatment by Bull, S J, Huezo-Diaz, P, Binder, E B, Cubells, J F, Ranjith, G, Maddock, C, Miyazaki, C, Alexander, N, Hotopf, M, Cleare, A J, Norris, S, Cassidy, E, Aitchison, K J, Miller, A H, Pariante, C M

“…Depression and fatigue are frequent side effects of interferon-α (IFN-α) treatment, and there is compelling evidence that the inflammatory response system…”
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Trajectories of change in depression severity during treatment with antidepressants by Uher, R, Muthén, B, Souery, D, Mors, O, Jaracz, J, Placentino, A, Petrovic, A, Zobel, A, Henigsberg, N, Rietschel, M, Aitchison, K J, Farmer, A, McGuffin, P

“…Response and remission defined by cut-off values on the last observed depression severity score are commonly used as outcome criteria in clinical trials, but…”
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Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis by Aas, M, Dazzan, P, Mondelli, V, Toulopoulou, T, Reichenberg, A, Di Forti, M, Fisher, H L, Handley, R, Hepgul, N, Marques, T, Miorelli, A, Taylor, H, Russo, M, Wiffen, B, Papadopoulos, A, Aitchison, K J, Morgan, C, Murray, R M, Pariante, C M

“…Cognitive impairment, particularly in memory and executive function, is a core feature of psychosis. Moreover, psychosis is characterized by a more prominent…”
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European Chlamydia abortus livestock isolate genomes reveal unusual stability and limited diversity, reflected in geographical signatures by Seth-Smith, H M B, Busó, Leonor Sánchez, Livingstone, M, Sait, M, Harris, S R, Aitchison, K D, Vretou, Evangelia, Siarkou, V I, Laroucau, K, Sachse, K, Longbottom, D, Thomson, N R

“…Chlamydia abortus (formerly Chlamydophila abortus) is an economically important livestock pathogen, causing ovine enzootic abortion (OEA), and can also cause…”
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Depressive disorder moderates the effect of the FTO gene on body mass index by Rivera, M, Cohen-Woods, S, Kapur, K, Breen, G, Ng, M Y, Butler, A W, Craddock, N, Gill, M, Korszun, A, Maier, W, Mors, O, Owen, M J, Preisig, M, Bergmann, S, Tozzi, F, Rice, J, Rietschel, M, Rucker, J, Schosser, A, Aitchison, K J, Uher, R, Craig, I W, Lewis, C M, Farmer, A E, McGuffin, P

“…There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has…”
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New insights into the pharmacogenomics of antidepressant response from the GENDEP and STARD studies: rare variant analysis and high-density imputation by Fabbri, C, Tansey, K E, Perlis, R H, Hauser, J, Henigsberg, N, Maier, W, Mors, O, Placentino, A, Rietschel, M, Souery, D, Breen, G, Curtis, C, Sang-Hyuk, L, Newhouse, S, Patel, H, Guipponi, M, Perroud, N, Bondolfi, G, O'Donovan, M, Lewis, G, Biernacka, J M, Weinshilboum, R M, Farmer, A, Aitchison, K J, Craig, I, McGuffin, P, Uher, R, Lewis, C M

“…Genome-wide association studies have generally failed to identify polymorphisms associated with antidepressant response. Possible reasons include limited…”
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Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project by Perroud, N, Uher, R, Ng, M Y M, Guipponi, M, Hauser, J, Henigsberg, N, Maier, W, Mors, O, Gennarelli, M, Rietschel, M, Souery, D, Dernovsek, M Z, Stamp, A S, Lathrop, M, Farmer, A, Breen, G, Aitchison, K J, Lewis, C M, Craig, I W, McGuffin, P

“…Suicidal thoughts during antidepressant treatment have been the focus of several candidate gene association studies. The aim of the present genome-wide…”
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Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population by Wolff, K., Tsapakis, E. M., Winstock, A. R., Hartley, D., Holt, D., Forsling, M. L., Aitchison, K. J.

“…Despite the common use of MDMA (ecstasy) in the UK, the mechanism underlying associated potentially fatal cerebral oedema is unclear. We used a new…”
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Genome-wide association analysis of copy number variation in recurrent depressive disorder by Rucker, J J H, Breen, G, Pinto, D, Pedroso, I, Lewis, C M, Cohen-Woods, S, Uher, R, Schosser, A, Rivera, M, Aitchison, K J, Craddock, N, Owen, M J, Jones, L, Jones, I, Korszun, A, Muglia, P, Barnes, M R, Preisig, M, Mors, O, Gill, M, Maier, W, Rice, J, Rietschel, M, Holsboer, F, Farmer, A E, Craig, I W, Scherer, S W, McGuffin, P

“…Large, rare copy number variants (CNVs) have been implicated in a variety of psychiatric disorders, but the role of CNVs in recurrent depression is unclear. We…”
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The genetics of affective disorder and suicide by McGuffin, P, Perroud, N, Uher, R, Butler, A, Aitchison, K.J, Craig, I, Lewis, C, Farmer, A

“…Abstract Suicidal behaviour shows evidence of familial clustering and the twin data on completed suicide suggest moderate heritability. The extent to which the…”
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Extracting a needle from a haystack: reanalysis of whole genome data reveals a readily translatable finding by Keers, R, Farmer, A E, Aitchison, K J

“…There is significant unmet need for more effective treatments for bipolar disorder. The drug discovery process is becoming prohibitively expensive. Hence,…”
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Familiality and SNP heritability of age at onset and episodicity in major depressive disorder by Ferentinos, P, Koukounari, A, Power, R, Rivera, M, Uher, R, Craddock, N, Owen, M J, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, J P, Ising, M, Maier, W, Mors, O, Rietschel, M, Preisig, M, Binder, E B, Aitchison, K J, Mendlewicz, J, Souery, D, Hauser, J, Henigsberg, N, Breen, G, Craig, I W, Farmer, A E, Müller-Myhsok, B, McGuffin, P, Lewis, C M

“…Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO)…”
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Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project by Keers, R, Uher, R, Huezo-Diaz, P, Smith, R, Jaffee, S, Rietschel, M, Henigsberg, N, Kozel, D, Mors, O, Maier, W, Zobel, A, Hauser, J, Souery, D, Placentino, A, Larsen, E R, Dmitrzak-Weglarz, M, Gupta, B, Hoda, F, Craig, I, McGuffin, P, Farmer, A E, Aitchison, K J

“…There is substantial inter-individual variation in response to antidepressants, and genetic variation may, in part, explain these differences. For example,…”
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Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line by Sugden, K., Pariante, CM, McGuffin, P., Aitchison, KJ, D'Souza, UM

“…Quantitative real-time polymerase chain reaction (PCR) is an effective approach in investigating the effects of exogenous compounds on gene expression. This is…”
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Interrater reliability of the Antipsychotic Non-Neurological Side-Effects Rating Scale measured in patients treated with clozapine by Ohlsen, RI, Williamson, R., Yusufi, B., Mullan, J., Irving, D., Mukherjee, S., Page, E., Aitchison, KJ, Barnes, TRE

“…The Antipsychotic Non-Neurological Side-Effects Rating Scale (ANNSERS) was developed to provide a comprehensive measure for rating non-neurological adverse…”
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Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration by Aitchison, K., Datla, K., Rooprai, H., Fernando, J., Dexter, D.

“…The tricyclic antidepressant (TCA) clomipramine has been widely used in psychiatry for over 40 years. More recently, its therapeutic potential as an…”
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Copy number variants and therapeutic response to antidepressant medication in major depressive disorder by Tansey, K E, Rucker, J J H, Kavanagh, D H, Guipponi, M, Perroud, N, Bondolfi, G, Domenici, E, Evans, D M, Hauser, J, Henigsberg, N, Jerman, B, Maier, W, Mors, O, O'Donovan, M, Peters, T J, Placentino, A, Rietschel, M, Souery, D, Aitchison, K J, Craig, I, Farmer, A, Wendland, J R, Malafosse, A, Lewis, G, Kapur, S, McGuffin, P, Uher, R

“…It would be beneficial to find genetic predictors of antidepressant response to help personalise treatment of major depressive disorder (MDD). Rare copy number…”
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A UK consensus on the administration of aripiprazole for the treatment of mania by Aitchison, KJ, Bienroth, M, Cookson, J, Gray, R, Haddad, PM, Moore, B, Ratna, L, Sullivan, G, Taylor, D, Taylor, M, Goodwin, GM

“…Abstract Aripiprazole has recently received approval for the treatment of moderate to severe manic episodes in bipolar I disorder and prevention of new manic…”
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