Search Results - "Aisen, Philip"

Structural basis for iron piracy by pathogenic Neisseria by Noinaj, Nicholas, Easley, Nicole C., Oke, Muse, Mizuno, Naoko, Gumbart, James, Boura, Evzen, Steere, Ashley N., Zak, Olga, Aisen, Philip, Tajkhorshid, Emad, Evans, Robert W., Gorringe, Andrew R., Mason, Anne B., Steven, Alasdair C., Buchanan, Susan K.

“…Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it…”
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Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi by Dadachova, Ekaterina, Bryan, Ruth A, Huang, Xianchun, Moadel, Tiffany, Schweitzer, Andrew D, Aisen, Philip, Nosanchuk, Joshua D, Casadevall, Arturo

“…Melanin pigments are ubiquitous in nature. Melanized microorganisms are often the dominating species in certain extreme environments, such as soils…”
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Structure of the Human Transferrin Receptor-Transferrin Complex by Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas

“…Iron, insoluble as free Fe 3+ and toxic as free Fe 2+, is distributed through the body as Fe 3+ bound to transferrin (Tf) for delivery to cells by endocytosis…”
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The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement by Dadachova, Ekaterina, Bryan, Ruth A., Howell, Robertha C., Schweitzer, Andrew D., Aisen, Philip, Nosanchuk, Joshua D., Casadevall, Arturo

“…Summary Melanized microorganisms are often found in environments with very high background radiation levels such as in nuclear reactor cooling pools and the…”
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Characterization of the Interaction between Diferric Transferrin and Transferrin Receptor 2 by Functional Assays and Atomic Force Microscopy by Ikuta, Katsuya, Yersin, Alexandre, Ikai, Atsushi, Aisen, Philip, Kohgo, Yutaka

“…Transferrin receptor 2 (TfR2), a homologue of the classical transferrin receptor 1 (TfR1), is found in two isoforms, α and β. Like TfR1, TfR2α is a type II…”
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Histoplasma capsulatum Synthesizes Melanin-Like Pigments In Vitro and during Mammalian Infection by NOSANCHUK, Joshua D, GOMEZ, Beatriz L, YOUNGCHIM, Sirida, DIEZ, Soraya, AISEN, Philip, ZANCOPE-OLIVEIRA, Rosely M, RESTREPO, Angela, CASADEVALL, Arturo, HAMILTON, Andrew J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Transferrin receptor 1 by Aisen, Philip

“…With the discovery that transferrin serves as the iron source for hemoglobin-synthesizing immature red blood cells came the demonstration that a cell surface…”
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The Influence of the Synergistic Anion on Iron Chelation by Ferric Binding Protein, a Bacterial Transferrin by Dhungana, Suraj, Taboy, Céline H., Anderson, Damon S., Vaughan, Kevin G., Aisen, Philip, Mietzner, Timothy A., Crumbliss, Alvin L.

“…Although the presence of an exogenous anion is a requirement for tight Fe3+ binding by the bacterial (Neisseria) transferrin nFbp, the identity of the…”
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Detection of Melanin-Like Pigments in the Dimorphic Fungal Pathogen Paracoccidioides brasiliensis In Vitro and during Infection by GOMEZ, Beatriz L, NOSANCHUK, Joshua D, DIEZ, Soraya, YOUNGCHIM, Sirida, AISEN, Philip, CANO, Luz E, RESTREPO, Angela, CASADEVALL, Arturo, HAMILTON, Andrew J

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Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells by Ikuta, Katsuya, Zak, Olga, Aisen, Philip

“…To secure iron from transferrin, hepatocytes use two pathways, one dependent on transferrin receptor (TfR 1) and the other, of greater capacity but lower…”
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Fe3+ Coordination and Redox Properties of a Bacterial Transferrin by Taboy, Céline H., Vaughan, Kevin G., Mietzner, Timothy A., Aisen, Philip, Crumbliss, Alvin L.

“…The Fe3+ binding site of recombinant nFbp, a ferric-binding protein found in the periplasmic space of pathogenic Neisseria, has been characterized by…”
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Binding and Release of Iron by Gel-Encapsulated Human Transferrin: Evidence for a Conformational Search by Navati, Mahantesh S., Samuni, Uri, Aisen, Philip, Friedman, Joel M.

“…Human transferrin is a single-chain bilobal protein with each of the two similar but not identical lobes in turn composed of two domains. Each lobe may assume…”
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T1 and T2 of ferritin solutions: effect of loading factor by Vymazal, J, Zak, O, Bulte, J W, Aisen, P, Brooks, R A

“…Proton magnetic relaxation times T1 and T2 were measured at field strengths from 0.05 T to 1.5 T in solutions of ferritin with loading factors from 90 to 3600…”
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A new role for the transferrin receptor in the release of iron from transferrin by Bali, Pawan K, Zak, Olga, Aisen, Philip

“…Iron removal by pyrophosphate from human serum diferric transferrin and the complex of transferrin with its receptor was studied in 0.05 M HEPES or MES buffers…”
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The transferrin receptor and the release of iron from transferrin by Aisen, P

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Chemistry and biology of eukaryotic iron metabolism by Aisen, Philip, Enns, Caroline, Wessling-Resnick, Marianne

“…With rare exceptions, virtually all studied organisms from Archaea to man are dependent on iron for survival. Despite the ubiquitous distribution and abundance…”
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The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex by Egan, Timothy J, Zak, Olga, Aisen, Philip

“…Rates of iron release from both sites of free transferrin at pH 7.4 are critically dependent upon ionic strength, because release appears to require binding of…”
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Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein by Sibille, J C, Kondo, H, Aisen, P

“…Like the rat peritoneal macrophage, the isolated Kupffer cell is capable of processing and releasing iron acquired by phagocytosis of immunosensitized…”
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Receptor-induced switch in site-site cooperativity during iron release by transferrin by Bali, Pawan K, Aisen, Philip

“…Iron removal by PPi from the N- and C-terminal binding sites of both free and receptor-complexed transferrin, when the partner site remains occupied with…”
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Cockroach transferrin closely resembles vertebrate transferrins in its metal ion-binding properties: A spectroscopic study by Gasdaska, John R., Law, John H., Bender, Christopher J., Aisen, Philip

“…The optical and electron paramagnetic resonance (EPR) spectroscopic properties of a transferrin from the cockroach Blaberus discoidalis have been investigated…”
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