Search Results - "Airley, Rachel E"

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics by Airley, Rachel E, Mobasheri, Ali

“…Cancer cells require a steady source of metabolic energy in order to continue their uncontrolled growth and proliferation. Accelerated glycolysis is one of the…”
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GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding by Airley, Rachel E., Loncaster, Juliette, Raleigh, James A., Harris, Adrian L., Davidson, Susan E., Hunter, Robert D., West, Catharine M.L., Stratford, Ian J.

“…The presence of hypoxia in tumours results in the overexpression of certain genes, which are controlled via the transcription factor HIF‐1. Hypoxic cells are…”
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Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas by Golinska, Monika, Troy, Helen, Chung, Yuen-Li, McSheehy, Paul M, Mayr, Manuel, Yin, Xiaoke, Ly, Lucy, Williams, Kaye J, Airley, Rachel E, Harris, Adrian L, Latigo, John, Perumal, Meg, Aboagye, Eric O, Perrett, David, Stubbs, Marion, Griffiths, John R

“…HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well…”
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Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts by Cowen, Rachel L, Patterson, Adam V, Telfer, Brian A, Airley, Rachel E, Hobbs, Steve, Phillips, Roger M, Jaffar, Mohammed, Stratford, Ian J, Williams, Kaye J

“…Indolequinones such as mitomycin C (MMC) require enzymatic bioreduction to yield cytotoxic moieties. An attractive approach to overcome the potential…”
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A protective role for HIF-1 in response to redox manipulation and glucose deprivation: implications for tumorigenesis by WILLIAMS, Kaye J, TELFER, Brian A, AIRLEY, Rachel E, PETERS, Hans P. W, SHERIDAN, Mary R, VAN DER KOGEL, Albert J, HARRIS, Adrian L, STRATFORD, Ian J

“…We have investigated the role of HIF-1 in the cellular response to redox modulation via the inhibition of oxidative phosphorylation. We demonstrate that…”
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