Search Results - "Airiau, Christian Y"

A single molecular descriptor to predict solution behavior of therapeutic antibodies by Kingsbury, Jonathan S, Saini, Amandeep, Auclair, Sarah Marie, Fu, Li, Lantz, Michaela M, Halloran, Kevin T, Calero-Rubio, Cesar, Schwenger, Walter, Airiau, Christian Y, Zhang, Jifeng, Gokarn, Yatin R

“…Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of developable mAb drug candidates with optimal manufacturability,…”
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Real-Time Process Analytical Technology Assurance for Flow Synthesis of Oligonucleotides by Rydzak, James W, White, David E, Airiau, Christian Y, Sterbenz, Jeffrey T, York, Brian D, Clancy, Donald J, Dai, Qunying

“…A feasibility study has been conducted using Process Analytical Technology (PAT) monitoring and chemometric modeling techniques to mitigate risks identified…”
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Component Detection Weighted Index of Analogy:  Similarity Recognition on Liquid Chromatographic Mass Spectral Data for the Characterization of Route/Process Specific Impurities in Pharmaceutical Tablets by Zomer, Simeone, Brereton, Richard G, Wolff, Jean-Claude, Airiau, Christian Y, Smallwood, Caroline

“…Detection and identification of impurities in pharmaceuticals is an essential task for determining the possible infringement of a patent. This article reports…”
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Principal component analysis in liquid chromatography proton nuclear magnetic resonance: differentiation of three regio-isomers by Airiau, Christian Y., Shen, Hailin, Brereton, Richard G.

“…1H LC–NMR is recorded of a 1:2:1 mixture of 2,6-, 1,3- and 2,3-dihydroxynaphthalene isomers which closely elute and have several resonances in common. The data…”
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Resolution of on-flow LC/NMR data by multivariate methods - a comparison by Shen, Hailin, Airiau, Christian Y., Brereton, Richard G.

“…Data from LC/NMR have some distinct characteristics, differing from those of LC/MS and LC/DAD. This paper compares several approaches for resolution on both a…”
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Resolution of LC/1H NMR data applied to a three-component mixture of polyaromatic hydrocarbons by Shen, Hailin, Airiau, Christian Y., Brereton, Richard G.

“…A three‐component mixture of naphthalene, anthracene and pyrene with the middle peak embedded was recorded using LC/1H NMR. Two case‐studies, one with tailing…”
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Lc-Nmr : An Alternative To Lc-Ms And Hplc-Dad For The Analysis Of Complex Mixtures by BRERETON, Richard G, SHEN, Hailin, AIRIAU, Christian Y

“…NMR (Nuclear magnetic resonance) spectroscopy has become an essential technique for the organic chemist for its interpretative power. However analytical…”
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Resolution of LC/ 1 H NMR data applied to a three‐component mixture of polyaromatic hydrocarbons by Shen, Hailin, Airiau, Christian Y., Brereton, Richard G.

“…Abstract A three‐component mixture of naphthalene, anthracene and pyrene with the middle peak embedded was recorded using LC/ 1 H NMR. Two case‐studies, one…”
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Resolution of on-flow liquid chromatography proton nuclear magnetic resonance using canonical correlation and constrained linear regression by Shen, Hailin, Airiau, Christian Y., Brereton, Richard G.

“…A method is described for the resolution of Liquid Chromatography Nuclear Magnetic Resonance (LC-NMR) data. Two practical case studies are presented, of 3 and…”
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High-performance liquid chromatography/electrospray tandem mass spectrometry of polycyclic aromatic hydrocarbons by Airiau, Christian Y., Brereton, Richard G., Crosby, John

“…Selected ion chromatograms of the polyaromatic hydrocarbons anthracene, pyrene and 1,2‐benzanthracene were recorded using high‐performance liquid…”
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Investigation of sulfhydryl groups in cabbage phospholipase D by combination of derivatization methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry by Hwang, In-Seong, Park, Sung-Jun, Roh, Tae-young, Choi, Myung-Un, Kim, Hie-Joon

“…All eight cysteine residues in 92 kDa cabbage phospholipase D (PLD), deduced from the cDNA sequence, were shown to have free sulfhydryl groups by analysis…”
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