Search Results - "Aimová, D"

Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems by Stiborová, M, Borek-Dohalská, L, Aimová, D, Kotrbová, V, Kukacková, K, Janouchová, K, Rupertová, M, Ryslavá, H, Hudecek, J, Frei, E

“…Ellipticine is an antineoplastic agent, whose mode of action is based mainly on DNA intercalation, inhibition of topoisomerase II and formation of DNA adducts…”
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Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice by Arlt, Volker M., Stiborová, Marie, Henderson, Colin J., Thiemann, Markus, Frei, Eva, Aimová, Dagmar, Singh, Rajinder, Gamboa da Costa, Gonçalo, Schmitz, Oliver J., Farmer, Peter B., Wolf, C. Roland, Phillips, David H.

“…Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are…”
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The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N 2-Oxide by Stiborová, Marie, Sejbal, Jan, Bořek-Dohalská, Lucie, Aimová, Dagmar, Poljaková, Jitka, Forsterová, Kristina, Rupertová, Martina, Wiesner, Jiří, Hudeček, Jiří, Wiessler, Manfred, Frei, Eva

“…Abstract Ellipticine is an antineoplastic agent, the mode of action of which is considered to be based on DNA intercalation and inhibition of topoisomerase II…”
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Formation and persistence of DNA adducts of anticancer drug ellipticine in rats by Stiborová, Marie, Rupertová, Martina, Aimová, Dagmar, Ryšlavá, Helena, Frei, Eva

“…Abstract Ellipticine is an antineoplastic agent, whose mode of antitumor and/or toxic side effects is based on DNA intercalation, inhibition of topoisomerase…”
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Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes by Kotrbová, Vera, Aimová, Dagmar, Brezinová, Anna, Janouchová, Katerina, Poljaková, Jitka, Frei, Eva, Stiborová, Marie

“…Ellipticine is a potent antineoplastic agent exhibiting multiple action mechanisms. Recently, we found that after cytochrome P450 (CYP)-mediated oxidation…”
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DNA adduct formation by the anticancer drug ellipticine in rats determined by super(32)P postlabeling by Stiborova, M, Breuer, A, Aimova, D, Stiborova-Rupertova, M, Wiessler, M, Frei, E

“…Ellipticine is a potent antineoplastic agent whose mode of action is considered to be based mainly on DNA intercalation and/or inhibition of topoisomerase II…”
Get full text