Search Results - "Aimoto, Megumi"

Torsadogenic Potential of HCN Channel Blocker Ivabradine Assessed in the Rabbit Proarrhythmia Model by Takahara, Akira, Kawakami, Satoshi, Aimoto, Megumi, Nagasawa, Yoshinobu

“…Torsadogenic effects of ivabradine, an inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, were assessed in an in vivo…”
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Aldosterone Robustly Promotes Atrial Fibrillation in the Presence of Chronic Volume Overload in Rats by Aimoto, Megumi, Nada, Mizuki, Nagasawa, Yoshinobu, Takahara, Akira

“…We investigated the modulatory effects of aldosterone on atrial remodeling induced by an abdominal aorto-venocaval shunt (AVS) in rats, as patients with…”
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Effects of the L/N-Type Ca2+ Channel Blocker Cilnidipine on the Cardiac Histological Remodelling and Inducibility of Atrial Fibrillation in High-Salt-Fed Rats by Harada, Eri, Sugino, Kazumi, Aimoto, Megumi, Takahara, Akira

“…High salt intake has been shown to induce hypertrophy and fibrosis in the atria and ventricles, which could result in the development of atrial fibrillation…”
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Cardiac Electropharmacological Effects of Antidiarrheal Drug Loperamide and Its Antidote Naloxone in Anesthetized Guinea Pigs by Takahara, Akira, Izawa, Sayaka, Seki, Shota, Aimoto, Megumi, Nagasawa, Yoshinobu

“…Cardiac electropharmacological effects of an antidiarrheal drug loperamide and its antidote naloxone were assessed in isoflurane-anesthetized guinea pigs…”
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The Antiarrhythmic Action of the Na+/Ca2+ Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits by Kawakami, Satoshi, Takada, Kazuhiro, Aimoto, Megumi, Nagasawa, Yoshinobu, Kusakabe, Taichi, Kato, Keisuke, Takahara, Akira

“…To clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid…”
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Differential Effects of Ca2+ Channel Blockers Nifedipine and Cilnidipine on Arterial Elasticity in the Aortic and Femoral Arterial Segments of Anesthetized Rabbits by Sato, Akira, Nagasawa, Yoshinobu, Suzuki, Honami, Sakuma, Kiyoshi, Chiba, Tatsuo, Aimoto, Megumi, Takahara, Akira

“…Ca2+ channel blockers have potent vasodilatory effects and excellent efficacy in preserving organ blood flow. These hemodynamic actions may be partly…”
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Role of Rho Kinase in Regulating Arterial Stiffness in Anesthetized Rabbits by Takahara, Akira, Matsumoto, Manami, Sato, Akira, Inose, Shuto, Aimoto, Megumi, Nagasawa, Yoshinobu

“…The effects of Rho kinase inhibitors fasudil and ripasudil on arterial stiffness were assessed using anesthetized rabbits, where the aortic β and femoral β…”
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Role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in the anesthetized atrioventricular block rabbit by Kawakami, Satoshi, Kambayashi, Ryuichi, Takada, Kazuhiro, Aimoto, Megumi, Nagasawa, Yoshinobu, Takahara, Akira

“…We analyzed role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in isoflurane-anesthetized atrioventricular block rabbits…”
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Chronic Volume Overload Caused by Abdominal Aorto-Venocaval Shunt Provides Arrhythmogenic Substrates in the Rat Atrium by Aimoto, Megumi, Yagi, Keita, Ezawa, Aya, Tsuneoka, Yayoi, Kumada, Kohei, Hasegawa, Takeshi, Kuze, Tetsuo, Chiba, Toshiki, Nagasawa, Yoshinobu, Tanaka, Hikaru, Takahara, Akira

“…Atrial enlargement is thought to provide arrhythmogenic substrates, leading to the induction of atrial fibrillation (AF). In this study, we investigated the…”
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Effects of Enhanced Intracranial Pressure on Blood Pressure and the Cardio-Ankle Vascular Index in Rabbits by Miyazaki, Chikao, Shimizu, Kazuhiro, Nagasawa, Yoshinobu, Chiba, Tatsuo, Sakuma, Kiyoshi, Aimoto, Megumi, Yamamoto, Tomoyuki, Takahashi, Mao, Sugo, Nobuo, Takahara, Akira, Shirai, Kohji

“…Aim: Stroke is well known to lead to hypertension; nevertheless, the role of vascular function in hypertension remains unclear. In this study, we aimed to…”
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Evaluating the relationship between ocular blood flow and systemic organ blood flow in hemorrhagic shock using a rabbit model by Watanabe, Kento, Shiba, Tomoaki, Takahara, Akira, Homma, Hiroshi, Komatsu, Tetsuya, Tanino, Yusuke, Nagasawa, Yoshinobu, Aimoto, Megumi, Hori, Yuichi

“…This study aimed to investigate the feasibility of utilizing noninvasive ocular blood flow measurements as potential indicators of systemic circulation in…”
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Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model by Kawakami, Satoshi, Nagasawa, Yoshinobu, Hagiwara-Nagasawa, Mihoko, Omura, Kensuke, Aimoto, Megumi, Takahara, Akira

“…We assessed the torsadogenic effects of a novel remyelinating drug clemastine for multiple sclerosis using an in vivo proarrhythmia model of acute…”
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Electrophysiological Response to Acehytisine Was Modulated by Aldosterone in Rats with Aorto-Venocaval Shunts by Cao, Xin, Aimoto, Megumi, Nagasawa, Yoshinobu, Zhang, Han-Xiao, Zhang, Cheng-Shun, Takahara, Akira

“…Aldosterone induces cardiac electrical and structural remodeling, which leads to the development of heart failure and/or atrial fibrillation (AF). However, it…”
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Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs by Nagasawa, Yoshinobu, Sakai, Kaori, Kurimoto, Rui, Kawakami, Satoshi, Aimoto, Megumi, Takahara, Akira

“…We investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram…”
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Analysis of effects of acute hypovolemia on arterial stiffness in rabbits monitored with cardio-ankle vascular index by Nagasawa, Yoshinobu, Shimoda, Akira, Shiratori, Hiroki, Morishita, Takenori, Sakuma, Kiyoshi, Chiba, Tatsuo, Cao, Xin, Kawakami, Satoshi, Aimoto, Megumi, Miyazaki, Chikao, Sato, Shuji, Takahashi, Mao, Shimizu, Kazuhiro, Shirai, Kohji, Takahara, Akira

“…Although elasticity of the conduit arteries is known to be contribute effective peripheral circulation via Windkessel effects, the relationship between changes…”
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The role of arterial stiffness in the onset of Takotsubo cardiomyopathy observed with noradrenaline administration and intracranial blood injection in rabbits by Takahashi, Mao, Miyazaki, Chikao, Xin, Cao, Sato, Shuji, Shimizu, Kazuhiro, Chiba, Tatsuo, Tsukuma, Hisayuki, Komatsu, Tetsuya, Aimoto, Megumi, Nagasawa, Yoshinobu, Takahara, Akira, Shirai, Kohji

“…Takotsubo cardiomyopathy (TCM) has been reported to occur after subarachnoid hemorrhage, and the involvement of a critical activity of catecholamines has been…”
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Acehytisine suppresses atrial fibrillation in rats with dilated atria caused by chronic volume overload by Cao, Xin, Nagasawa, Yoshinobu, Zhang, Chengshun, Zhang, Hanxiao, Aimoto, Megumi, Takahara, Akira

“…Atrial dilation is an independent risk factor for the development of atrial fibrillation (AF) and modulates the efficacy of anti-AF drugs, leading to the…”
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Electropharmacological profile of an atrial-selective sodium channel blocker acehytisine assessed in the isoflurane-anesthetized guinea-pig model by Cao, Xin, Nagasawa, Yoshinobu, Zhang, Chengshun, Zhang, Hanxiao, Aimoto, Megumi, Takahara, Akira

“…Experimental evidence regarding the risk of proarrhythmic potential of acehytisine is limited. We assessed its electropharmacological effect together with…”
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Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits by Sakuma, Kiyoshi, Shimoda, Akira, Shiratori, Hiroaki, Komatsu, Tetsuya, Watanabe, Kento, Chiba, Tatsuo, Aimoto, Megumi, Nagasawa, Yoshinobu, Hori, Yuichi, Shirai, Kohji, Takahara, Akira

“…The cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological…”
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Physiological role of nitric oxide for regulation of arterial stiffness in anesthetized rabbits by Chiba, Tatsuo, Sakuma, Kiyoshi, Komatsu, Tetsuya, Cao, Xin, Aimoto, Megumi, Nagasawa, Yoshinobu, Shimizu, Kazuhiro, Takahashi, Mao, Hori, Yuichi, Shirai, Kohji, Takahara, Akira

“…We assessed effects of acetylcholine and Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME) on the cardio-ankle vascular index (CAVI), an indicator of…”
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