Search Results - "Ailing Xue"

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
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Senolytics reduce coronavirus-related mortality in old mice by Camell, Christina D, Yousefzadeh, Matthew J, Zhu, Yi, Prata, Larissa G P Langhi, Huggins, Matthew A, Pierson, Mark, Zhang, Lei, O'Kelly, Ryan D, Pirtskhalava, Tamar, Xun, Pengcheng, Ejima, Keisuke, Xue, Ailing, Tripathi, Utkarsh, Espindola-Netto, Jair Machado, Giorgadze, Nino, Atkinson, Elizabeth J, Inman, Christina L, Johnson, Kurt O, Cholensky, Stephanie H, Carlson, Timothy W, LeBrasseur, Nathan K, Khosla, Sundeep, O'Sullivan, M Gerard, Allison, David B, Jameson, Stephen C, Meves, Alexander, Li, Ming, Prakash, Y S, Chiarella, Sergio E, Hamilton, Sara E, Tchkonia, Tamara, Niedernhofer, Laura J, Kirkland, James L, Robbins, Paul D

“…The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically ill to severe acute respiratory syndrome coronavirus 2…”
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Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells by Carmona, Eva M, Lamont, Jeffrey D, Xue, Ailing, Wylam, Mark, Limper, Andrew H

“…Respiratory failure secondary to alveolar inflammation during Pneumocystis pneumonia is a major cause of death in immunocompromised patients. Neutrophil…”
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Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers by Xiong, Yuning, Dowdy, Sean C., Xue, Ailing, Shujuan, Jiang, Eberhardt, Norman L., Podratz, Karl C., Jiang, Shi-Wen

“…To examine the DNA methyltransferase (DNMT) mRNA and protein levels in endometrioid and serous cancers and to study the relationship between DNA…”
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Distribution of Major Basic Protein on Human Airway following In Vitro Eosinophil Incubation by Xue, Ailing, Wang, John, Sieck, Gary C., Wylam, Mark E.

“…Major basic protein (MBP) released from activated eosinophils may influence airway hyperresponsiveness (AHR) by either direct effects on airway myocytes or by…”
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease by Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.

“…Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with…”
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HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity by Xue, Ailing, Chapoval, Svetlana P., Finn, Elizabeth S., Chowdhary, Vaidehi R., Marietta, Eric V., Gaffey, Thomas A., Pursifull, Alex C., David, Chella S.

“…Several million individuals are exposed to agents in the workplace associated with atopy and asthma. Detergent enzymes have been implicated in occupationally…”
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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3 by Tripathi, Utkarsh, Nchioua, Rayhane, Prata, Larissa G P Langhi, Zhu, Yi, Gerdes, Erin O Wissler, Giorgadze, Nino, Pirtskhalava, Tamar, Parker, Erik, Xue, Ailing, Espindola-Netto, Jair Machado, Stenger, Steffen, Robbins, Paul D, Niedernhofer, Laura J, Dickinson, Stephanie L, Allison, David B, Kirchhoff, Frank, Sparrer, Konstantin Maria Johannes, Tchkonia, Tamar, Kirkland, James L

“…Senescent cells, which arise due to damage-associated signals, are apoptosis-resistant and can express a pro-inflammatory, tissue-destructive…”
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Emicizumab Prophylaxis for the Treatment of Chinese Hemophilia A Patients in the Real World: A Multi-Center Retrospective Analysis by Xu, Yuan, Wang, Ying, Wu, Runhui, Zheng, Changcheng, Xiao, Jianwen, Xu, Weiqun, Feng, Xiaoqin, Wang, Hua, Cao, Xiangshan, He, Liya, Xue, Tianyang, Jin, Mingwei, Xie, Bingshou, Ling, Jing, Sun, Lirong, Su, Rui, Cheng, Hongbo, Fang, Yongjun, Li, Bai, Yu, Ziqiang, Xue, Ailing, Sun, Mei, Yang, Li, Zhou, Zeping, Zhou, Hu, Jin, Jiao, Zhou, Min, Chen, Rong, Liu, Wei, Zhang, Lei, Xue, Feng, Yang, Renchi

“…Background The real-world experiences of Hemophilia A (HA) patients receiving emicizumab prophylaxis in China are insufficient due to the high cost and later…”
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Thrombin generation profiles as predictors of symptomatic venous thromboembolism after trauma: A prospective cohort study by Park, Myung S, Spears, Grant M, Bailey, Kent R, Xue, Ailing, Ferrara, Michael J, Headlee, Amy, Dhillon, Sabtir K, Jenkins, Donald H, Zietlow, Scott P, Harmsen, William S, Ashrani, Aneel A, Heit, John A

“…Reliable biomarkers predictive of venous thromboembolism (VTE) after acute trauma are uncertain. The objective of the study was to identify risk factors for…”
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Thrombin generation and procoagulant microparticle profiles after acute trauma: A prospective cohort study by Park, Myung S, Xue, Ailing, Spears, Grant M, Halling, Timothy M, Ferrara, Michael J, Kuntz, Melissa M, Dhillon, Sabtir K, Jenkins, Donald H, Harmsen, William S, Ballman, Karla V, Harrison, Paul, Heit, John A

“…The two sides of trauma-induced coagulopathy, the hypocoagulable and the hypercoagulable states, are poorly understood. To identify potential mechanisms for…”
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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans by Zhu, Yi, Prata, Larissa G.P. Langhi, Gerdes, Erin O. Wissler, Netto, Jair Machado Espindola, Pirtskhalava, Tamar, Giorgadze, Nino, Tripathi, Utkarsh, Inman, Christina L., Johnson, Kurt O., Xue, Ailing, Palmer, Allyson K., Chen, Tingjun, Schaefer, Kalli, Justice, Jamie N., Nambiar, Anoop M., Musi, Nicolas, Kritchevsky, Stephen B., Chen, Jun, Khosla, Sundeep, Jurk, Diana, Schafer, Marissa J., Tchkonia, Tamar, Kirkland, James L.

“…α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the…”
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Transcriptome Analysis of Lymphoma Edited Monocyte Phenotype by Lin, Yi, Dudakovic, Amel, Thaler, Roman, Xue, Ailing, Le-Rademacher, Jennifer, Pederson, Levy D., Gastineau, Dennis A., Dietz, Allan, van Wijnen, Andre

“…Background: Immune editing is a major mechanism used by tumors to promote its survival. Checkpoint inhibitors demonstrated clinical utilities of targeting…”
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Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes by White, Thomas A, Xue, Ailing, Chini, Eduardo N, Thompson, Michael, Sieck, Gary C, Wylam, Mark E

“…Previous studies have suggested that the proinflammatory cytokine, TNF-alpha, contributes to airway hyperresponsivness by altering airway smooth muscle (ASM)…”
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Mechanisms of intrinsic force in small human airways by Wylam, Mark E, Xue, Ailing, Sieck, Gary C

“…Highlights ► Intrinsic force generation is a fundamental property of human airway smooth muscle. ► Intrinsic force can be identified by reducing extracellular…”
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney diseaseResearch in context by LaTonya J. Hickson, Larissa G.P. Langhi Prata, Shane A. Bobart, Tamara K. Evans, Nino Giorgadze, Shahrukh K. Hashmi, Sandra M. Herrmann, Michael D. Jensen, Qingyi Jia, Kyra L. Jordan, Todd A. Kellogg, Sundeep Khosla, Daniel M. Koerber, Anthony B. Lagnado, Donna K. Lawson, Nathan K. LeBrasseur, Lilach O. Lerman, Kathleen M. McDonald, Travis J. McKenzie, João F. Passos, Robert J. Pignolo, Tamar Pirtskhalava, Ishran M. Saadiq, Kalli K. Schaefer, Stephen C. Textor, Stella G. Victorelli, Tammie L. Volkman, Ailing Xue, Mark A. Wentworth, Erin O. Wissler Gerdes, Yi Zhu, Tamara Tchkonia, James L. Kirkland

“…Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP),…”
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Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456 by Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Allison, David B., Dickinson, Stephanie L., Ejima, Keisuke, Atkinson, Elizabeth J., Lenburg, Marc, Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.

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Pneumocystis cell wall b-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells by Carmona, Eva M, Lamont, Jeffrey D, Xue, Ailing, Wylam, Mark, Limper, Andrew H

“…Respiratory failure secondary to alveolar inflammation during Pneumocystis pneumonia is a major cause of death in immunocompromised patients. Neutrophil…”
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Pneumocystis cell wall [beta]-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells by Carmona, Eva M, Lamont, Jeffrey D, Xue, Ailing, Wylam, Mark, Limper, Andrew H

“…Background Respiratory failure secondary to alveolar inflammation during Pneumocystis pneumonia is a major cause of death in immunocompromised patients…”
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CD38 Involvement in TNF‐α Induced Changes in Airway Smooth Muscle Ca2+ Homeostasis by White, Thomas A, Xue, Ailing, Sieck, Gary C, Wylam, Mark E

“…The pro‐inflammatory cytokine TNF‐α may contribute to airway hyperresponsivness (AHR) in asthma by altering airway smooth muscle (ASM) Ca2+ homeostasis…”
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