Search Results - "Aikawa, Shizu"

Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes by Aikawa, Shizu, Deng, Wenbo, Liang, Xiaohuan, Yuan, Jia, Bartos, Amanda, Sun, Xiaofei, Dey, Sudhansu K.

“…A reciprocal communication between the implantation-competent blastocyst and the receptive uterus is essential to successful implantation and pregnancy…”
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Primary decidual zone formation requires Scribble for pregnancy success in mice by Yuan, Jia, Aikawa, Shizu, Deng, Wenbo, Bartos, Amanda, Walz, Gerd, Grahammer, Florian, Huber, Tobias B., Sun, Xiaofei, Dey, Sudhansu K.

“…Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo signaling. This study shows that Scrib is expressed in…”
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Incidence and Clinical Features of Venous Thromboembolism in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan by Yamashita, Yugo, Maruyama, Yuuki, Satokawa, Hirono, Nishimoto, Yuji, Tsujino, Ichizo, Sakashita, Hideki, Nakata, Hiroko, Okuno, Yoshinori, Ogihara, Yoshito, Yachi, Sen, Toya, Naoki, Shingaki, Masami, Ikeda, Satoshi, Yamamoto, Naoto, Aikawa, Shizu, Ikeda, Nobutaka, Hayashi, Hiroya, Ishiguro, Shingo, Iwata, Eriko, Umetsu, Michihisa, Kondo, Akane, Iwai, Takehisa, Kobayashi, Takao, Mo, Makoto, Yamada, Norikazu, on behalf of the Taskforce of VTE and COVID-19 in Japan Study

“…Background:Coronavirus disease 2019 (COVID-19) reportedly causes venous thromboembolism (VTE), but the status of this complication in Japan was unclear.Methods…”
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Uterine prostaglandin DP receptor-induced upon implantation contributes to decidualization together with EP4 receptor by Sakamoto, Risa, Fujiwara, Takuji, Kawano, Yuko, Aikawa, Shizu, Inazumi, Tomoaki, Nakayama, On, Kawasaki-Shirata, Yukiko, Hashimoto-Iwasaki, Miho, Sugimoto, Toshiko, Tsuchiya, Soken, Nakao, Satohiro, Takeo, Toru, Hirota, Yasushi, Sugimoto, Yukihiko

“…To investigate the yet-unknown roles of prostaglandins (PGs) in the uterus, we analyzed the expression of various PG receptors in the uterus. We found that…”
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Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females by Hiraoka, Takehiro, Hirota, Yasushi, Aikawa, Shizu, Iida, Rei, Ishizawa, Chihiro, Kaku, Tetsuaki, Hirata, Tomoyuki, Fukui, Yamato, Akaeda, Shun, Matsuo, Mitsunori, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Osuga, Yutaka

“…Adenomyosis is a benign uterine disease that causes dysmenorrhea, heavy menstrual bleeding, and infertility; however, its pathophysiology remains unclear…”
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Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation by Gebril, Mona, Hirota, Yasushi, Aikawa, Shizu, Fukui, Yamato, Kaku, Tetsuaki, Matsuo, Mitsunori, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Taha, Tamer, Balah, Osama Al, Elnoury, Mohamed Amr H, Fujii, Tomoyuki, Osuga, Yutaka

“…Progesterone receptor (PGR) is indispensable for pregnancy in mammals. Uterine PGR responds to the heightened levels of ovarian progesterone (P4) after…”
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Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment by Fukui, Yamato, Hirota, Yasushi, Saito-Fujita, Tomoko, Aikawa, Shizu, Hiraoka, Takehiro, Kaku, Tetsuaki, Hirata, Tomoyuki, Akaeda, Shun, Matsuo, Mitsunori, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Ikawa, Masahito, Osuga, Yutaka

“…Recent studies have demonstrated that the formation of an implantation chamber composed of a uterine crypt, an implantation-competent blastocyst, and uterine…”
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Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment by Hiraoka, Takehiro, Hirota, Yasushi, Fukui, Yamato, Gebril, Mona, Kaku, Tetsuaki, Aikawa, Shizu, Hirata, Tomoyuki, Akaeda, Shun, Matsuo, Mitsunori, Haraguchi, Hirofumi, Saito-Kanatani, Mayuko, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Yoshino, Osamu, Fujii, Tomoyuki, Osuga, Yutaka

“…Although it has been reported that uterine signal transducer and activator of transcription 3 (STAT3) is essential for embryo implantation, the exact roles of…”
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Association Between the Development of Thrombosis and Worsening of Disease Severity in Patients With Moderate COVID-19 on Admission　― From the CLOT-COVID Study by Ikeda, Satoshi, Ueno, Yuki, Maemura, Koji, Yachi, Sen, Takeyama, Makoto, Nishimoto, Yuji, Tsujino, Ichizo, Nakamura, Junichi, Yamamoto, Naoto, Nakata, Hiroko, Umetsu, Michihisa, Aikawa, Shizu, Hayashi, Hiroya, Satokawa, Hirono, Okuno, Yoshinori, Iwata, Eriko, Ogihara, Yoshito, Ikeda, Nobutaka, Kondo, Akane, Iwai, Takehisa, Yamada, Norikazu, Ogawa, Tomohiro, Kobayashi, Takao, Mo, Makoto, Yamashita, Yugo, on behalf of the CLOT-COVID Study Investigators

“…Background: The worsening of coronavirus disease 2019 (COVID-19) severity is a critical issue in current clinical settings and may be associated with the…”
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Therapeutic-Dose vs. Prophylactic-Dose Anticoagulation Therapy for Critically Ill Patients With COVID-19 in a Practice-Based Observational Study by Yamashita, Yugo, Yachi, Sen, Takeyama, Makoto, Nishimoto, Yuji, Tsujino, Ichizo, Nakamura, Junichi, Yamamoto, Naoto, Nakata, Hiroko, Ikeda, Satoshi, Umetsu, Michihisa, Aikawa, Shizu, Hayashi, Hiroya, Satokawa, Hirono, Okuno, Yoshinori, Iwata, Eriko, Ogihara, Yoshito, Ikeda, Nobutaka, Kondo, Akane, Iwai, Takehisa, Yamada, Norikazu, Ogawa, Tomohiro, Kobayashi, Takao, Mo, Makoto

“…Background: The potential benefit of therapeutic-dose anticoagulation for critically ill patients with coronavirus disease 2019 (COVID-19) is still…”
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DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice by Hiratsuka, Daiki, Aikawa, Shizu, Hirota, Yasushi, Fukui, Yamato, Akaeda, Shun, Hiraoka, Takehiro, Matsuo, Mitsunori, Osuga, Yutaka

“…Under ovarian hormone control, dormant blastocysts obtain implantation capacity (known as blastocyst activation) through their global gene expression. After…”
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Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion by Akaeda, Shun, Hirota, Yasushi, Fukui, Yamato, Aikawa, Shizu, Shimizu-Hirota, Ryoko, Kaku, Tetsuaki, Gebril, Mona, Hirata, Tomoyuki, Hiraoka, Takehiro, Matsuo, Mitsunori, Haraguchi, Hirofumi, Saito-Kanatani, Mayuko, Takeda, Norihiko, Fujii, Tomoyuki, Osuga, Yutaka

“…Retinoblastoma protein (RB) encoded by Rb1 is a prominent inducer of cell cycle arrest (CCA). The hormone progesterone (P 4 ) promotes CCA in the uterine…”
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The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion by Fukui, Yamato, Hirota, Yasushi, Aikawa, Shizu, Sakashita, Akihiko, Shimizu-Hirota, Ryoko, Takeda, Norihiko, Ishizawa, Chihiro, Iida, Rei, Kaku, Tetsuaki, Hirata, Tomoyuki, Hiraoka, Takehiro, Akaeda, Shun, Matsuo, Mitsunori, Osuga, Yutaka

“…Infertility occurs in 15% of couples worldwide. Recurrent implantation failure (RIF) is one of the major problems in in vitro fertilization and embryo transfer…”
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Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study by Yamashita, Yugo, Yachi, Sen, Takeyama, Makoto, Nishimoto, Yuji, Tsujino, Ichizo, Nakamura, Junichi, Yamamoto, Naoto, Nakata, Hiroko, Ikeda, Satoshi, Umetsu, Michihisa, Aikawa, Shizu, Hayashi, Hiroya, Satokawa, Hirono, Okuno, Yoshinori, Iwata, Eriko, Ogihara, Yoshito, Ikeda, Nobutaka, Kondo, Akane, Iwai, Takehisa, Yamada, Norikazu, Ogawa, Tomohiro, Kobayashi, Takao, Mo, Makoto

“…Aim: There is scarce data on the impact of age on clinical outcomes in patients with coronavirus disease 2019 (COVID-19).Method: The CLOT-COVID Study was a…”
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A gene network of uterine luminal epithelium organizes mouse blastocyst implantation by Aikawa, Shizu, Hirota, Yasushi, Fukui, Yamato, Ishizawa, Chihiro, IIda, Rei, Kaku, Tetsuaki, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Matsuo, Mitsunori, Osuga, Yutaka

“…Purpose The receptive endometrium is critical for blastocyst implantation. In mice, after blastocysts enter the uterine cavities on day 4 of pregnancy (day…”
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Uterine Receptivity is Reflected by LIF Expression in the Cervix by Fukui, Yamato, Hirota, Yasushi, Aikawa, Shizu, Ishizawa, Chihiro, Iida, Rei, Kaku, Tetsuaki, Hirata, Tomoyuki, Akaeda, Shun, Hiraoka, Takehiro, Matsuo, Mitsunori, Osuga, Yutaka

“…Recurrent implantation failure is a major problem in assisted reproductive technology (ART). Although ART systems have evolved rapidly over the decades, it is…”
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The current status of thrombosis and anticoagulation therapy in patients with COVID-19 in Japan: From the CLOT-COVID study by Nishimoto, Yuji, Yachi, Sen, Takeyama, Makoto, Tsujino, Ichizo, Nakamura, Junichi, Yamamoto, Naoto, Nakata, Hiroko, Ikeda, Satoshi, Umetsu, Michihisa, Aikawa, Shizu, Hayashi, Hiroya, Satokawa, Hirono, Okuno, Yoshinori, Iwata, Eriko, Ogihara, Yoshito, Ikeda, Nobutaka, Kondo, Akane, Iwai, Takehisa, Yamada, Norikazu, Ogawa, Tomohiro, Kobayashi, Takao, Mo, Makoto, Yamashita, Yugo

“…Data on thrombosis and current real-world management strategies for anticoagulation therapy are scarce but important for understanding current issues and unmet…”
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The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells by Kobayashi, Ryosuke, Tajika, Yuki, Kohmaru, Junki, Morita, Sumiyo, Horii, Takuro, Mizukami, Yoichi, Aikawa, Shizu, Hirota, Yasushi, Hatada, Izuho

“…Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation…”
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Influence of obesity on incidence of thrombosis and disease severity in patients with COVID-19: From the CLOT-COVID study by Ogihara, Yoshito, Yachi, Sen, Takeyama, Makoto, Nishimoto, Yuji, Tsujino, Ichizo, Nakamura, Junichi, Yamamoto, Naoto, Nakata, Hiroko, Ikeda, Satoshi, Umetsu, Michihisa, Aikawa, Shizu, Hayashi, Hiroya, Satokawa, Hirono, Okuno, Yoshinori, Iwata, Eriko, Ikeda, Nobutaka, Kondo, Akane, Iwai, Takehisa, Yamada, Norikazu, Ogawa, Tomohiro, Kobayashi, Takao, Mo, Makoto, Yamashita, Yugo

“…The influence of obesity on the development of thrombosis and severity of coronavirus disease 2019 (COVID-19) remains unclear. The CLOT-COVID study was a…”
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Mortality-associated Risk Factors in Hospitalized COVID-19 Patients in Japan: Findings of the CLOT-COVID Study by Takeyama, Makoto, Yachi, Sen, Nishimoto, Yuji, Tsujino, Ichizo, Nakamura, Junichi, Yamamoto, Naoto, Nakata, Hiroko, Ikeda, Satoshi, Umetsu, Michihisa, Aikawa, Shizu, Hayashi, Hiroya, Satokawa, Hirono, Okuno, Yoshinori, Iwata, Eriko, Ogihara, Yoshito, Ikeda, Nobutaka, Kondo, Akane, Iwai, Takehisa, Yamada, Norikazu, Ogawa, Tomohiro, Kobayashi, Takao, Mo, Makoto, Yamashita, Yugo

“…Background: Reports of mortality-associated risk factors in patients with the novel coronavirus disease 2019 (COVID-19) are limited.Methods: We evaluated the…”
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