Search Results - "Aigul, Galembikova"

A Novel Receptor Tyrosine Kinase Switch Promotes Gastrointestinal Stromal Tumor Drug Resistance by Boichuk, Sergei, Galembikova, Aigul, Dunaev, Pavel, Valeeva, Elena, Shagimardanova, Elena, Gusev, Oleg, Khaiboullina, Svetlana

“…The fact that most gastrointestinal stromal tumors (GISTs) acquire resistance to imatinib (IM)-based targeted therapy remains the main driving force to…”
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Computational-Based Discovery of the Anti-Cancer Activities of Pyrrole-Based Compounds Targeting the Colchicine-Binding Site of Tubulin by Boichuk, Sergei, Syuzov, Kirill, Bikinieva, Firuza, Galembikova, Aigul, Zykova, Svetlana, Gankova, Ksenia, Igidov, Sergei, Igidov, Nazim

“…Despite the tubulin-binding agents (TBAs) that are widely used in the clinic for cancer therapy, tumor resistance to TBAs (both inherited and acquired)…”
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The Design, Synthesis, and Biological Activities of Pyrrole-Based Carboxamides: The Novel Tubulin Inhibitors Targeting the Colchicine-Binding Site by Boichuk, Sergei, Galembikova, Aigul, Syuzov, Kirill, Dunaev, Pavel, Bikinieva, Firuza, Aukhadieva, Aida, Zykova, Svetlana, Igidov, Nazim, Gankova, Ksenia, Novikova, Maria, Kopnin, Pavel

“…Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These…”
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2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines by Boichuk, Sergei, Galembikova, Aigul, Bikinieva, Firuza, Dunaev, Pavel, Aukhadieva, Aida, Syuzov, Kirill, Zykova, Svetlana, Igidov, Nazim, Ksenofontov, Alexander, Bocharov, Pavel

“…Microtubules are known as the most attractive molecular targets for anti-cancer drugs. However, the number of serious limitations of the microtubule targeting…”
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Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair by Boichuk, Sergei, Bikinieva, Firuza, Nurgatina, Ilmira, Dunaev, Pavel, Valeeva, Elena, Aukhadieva, Aida, Sabirov, Alexey, Galembikova, Aigul

“…Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is well documented for a broad spectrum of human malignancies supporting their growth and…”
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2-Amino-Pyrrole-Carboxylate Attenuates Homology-Mediated DNA Repair and Sensitizes Cancer Cells to Doxorubicin by Boichuk, Sergei, Bikinieva, Firuza, Mustafin, Ilshat, Zykova, Svetlana, Ryzkin, Sergei, Galembikova, Aigul

“…Despite a high efficacy of chemotherapy in cancer treatment, acquired resistance of tumors to certain chemotherapeutic agents and frequent side effects remain…”
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Imbalance between Actin Isoforms Contributes to Tumour Progression in Taxol-Resistant Triple-Negative Breast Cancer Cells by Dugina, Vera, Vasileva, Maria, Khromova, Natalia, Vinokurova, Svetlana, Shagieva, Galina, Mikheeva, Ekaterina, Galembikova, Aigul, Dunaev, Pavel, Kudlay, Dmitry, Boichuk, Sergei, Kopnin, Pavel

“…The widespread occurrence of breast cancer and its propensity to develop drug resistance highlight the need for a comprehensive understanding of the molecular…”
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Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo by Boichuk, Sergei, Galembikova, Aigul, Dunaev, Pavel, Micheeva, Ekaterina, Valeeva, Elena, Novikova, Maria, Khromova, Natalya, Kopnin, Pavel

“…Dysregulation of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling pathway is frequently observed in multiple human…”
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Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors by Sergei, Boichuk, Pavel, Dunaev, Aigul, Galembikova, Firyuza, Bikinieva, Ilmira, Nurgatina, Ilshat, Mustafin, Aida, Aukhadieva, Refat, Kurtasanov, Natalia, Andriutsa, Elena, Shagimardanova, Vera, Gorbunova

“…Deregulation of receptor tyrosine kinase (RTK)-signaling is frequently observed in many human malignancies, making activated RTKs the promising therapeutic…”
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Infigratinib (BGJ 398), a Pan-FGFR Inhibitor, Targets P-Glycoprotein and Increases Chemotherapeutic-Induced Mortality of Multidrug-Resistant Tumor Cells by Boichuk, Sergei, Dunaev, Pavel, Mustafin, Ilshat, Mani, Shinjit, Syuzov, Kirill, Valeeva, Elena, Bikinieva, Firuza, Galembikova, Aigul

“…The microtubule-targeting agents (MTAs) are well-known chemotherapeutic agents commonly used for therapy of a broad spectrum of human malignancies, exhibiting…”
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Establishment and Characterization of Multi-Drug Resistant p53-Negative Osteosarcoma SaOS-2 Subline by Boichuk, Sergei, Bikinieva, Firyuza, Valeeva, Elena, Dunaev, Pavel, Vasileva, Maria, Kopnin, Pavel, Mikheeva, Ekaterina, Ivoilova, Tatyana, Mustafin, Ilshat, Galembikova, Aigul

“…Aim: To establish a p53-negative osteosarcoma (OS) SaOS-2 cellular subline exhibiting resistance to specific chemotherapeutic agents, including topoisomerase…”
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Unraveling the Mechanism of Platelet Aggregation Suppression by Thioterpenoids: Molecular Docking and In Vivo Antiaggregant Activity by Nikitina, Liliya E, Bocharov, Pavel S, Ksenofontov, Alexander A, Antina, Elena V, Gilfanov, Ilmir R, Pavelyev, Roman S, Ostolopovskaya, Olga V, Fedyunina, Inna V, Azizova, Zulfiya R, Pestova, Svetlana V, Izmest'ev, Evgeniy S, Rubtsova, Svetlana A, Boichuk, Sergei V, Galembikova, Aigul R, Smolyarchuk, Elena A, Mustafin, Ilshat G, Kayumov, Airat R, Samorodov, Aleksandr V

“…Natural monoterpenes and their derivatives are widely considered the effective ingredients for the design and production of novel biologically active…”
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Unraveling the Mechanism of Platelet Aggregation Suppression by Monoterpenoids by Nikitina, Liliya E, Pavelyev, Roman S, Gilfanov, Ilmir R, Kiselev, Sergei V, Azizova, Zulfiya R, Ksenofontov, Alexander A, Bocharov, Pavel S, Antina, Elena V, Klochkov, Vladimir V, Timerova, Ayzira F, Rakhmatullin, Ilfat Z, Ostolopovskaya, Olga V, Khelkhal, Mohammed A, Boichuk, Sergei V, Galembikova, Aigul R, Andriutsa, Natalia S, Frolova, Larisa L, Kutchin, Alexander V, Kayumov, Airat R

“…Platelet aggregation causes various diseases and therefore challenges the development of novel antiaggregatory drugs. In this study, we report the possible…”
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Fibroblast Growth Factor 2 (FGF2) Activates Vascular Endothelial Growth Factor (VEGF) Signaling in Gastrointestinal Stromal Tumors (GIST): An Autocrine Mechanism Contributing to Imatinib Mesylate (IM) Resistance by Boichuk, Sergei, Dunaev, Pavel, Galembikova, Aigul, Valeeva, Elena

“…We showed previously that the autocrine activation of the FGFR-mediated pathway in GIST lacking secondary mutations was a result of the inhibition of KIT…”
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Inhibition of fibroblast growth factor receptor-signaling sensitizes imatinib-resistant gastrointestinal stromal tumors to low doses of topoisomerase II inhibitors by Boichuk, Sergei, Dunaev, Pavel, Galembikova, Aigul, Mustafin, Ilshat, Valeeva, Elena

“…The acquired resistance of gastrointestinal stromal tumors (GISTs) to the targeted-based therapy remains the driving force to identify the novel approaches…”
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Carboxyl-BODIPY based fluorescent biomarkers: Spectral characteristics, photostability and possibilities for practical application by Guseva, Galina B., Lukanov, Michail M., Ksenofontov, Alexander A., Antina, Elena V., Lisovskaya, Svetlana, Nikitina, Liliya E., Galembikova, Aigul R., Boichuk, Sergey V.

“…[Display omitted] •The spectral properties of α- and meso-carboxyl-BODIPYs are compared.•Carboxyl-BODIPYs are stable over a wide pH range and intensely…”
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Establishment and characterization of a triple negative basal-like breast cancer cell line with multi-drug resistance by Boichuk, Sergei, Galembikova, Aigul, Sitenkov, Alexandr, Khusnutdinov, Ramil, Dunaev, Pavel, Valeeva, Elena, Usolova, Natalia

“…Triple-negative breast carcinoma (TNBC) is one of the most aggressive subtypes of breast cancer and is associated with an unfavorable prognosis. The management…”
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Leaf Extract from European Olive (Olea europaea L.) Post-Transcriptionally Suppresses the Epithelial-Mesenchymal Transition and Sensitizes Gastric Cancer Cells to Chemotherapy by Tekin, Cagla, Ercelik, Melis, Dunaev, Pavel, Galembikova, Aigul, Tezcan, Gulcin, Aksoy, Secil Ak, Budak, Ferah, Isık, Ozgen, Ugras, Nesrin, Boichuk, Sergei, Tunca, Berrin

“…The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to cancer spreading and…”
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Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo by Boichuk, Sergei, Galembikova, Aigul, Dunaev, Pavel, Micheeva, Ekaterina, Novikova, Maria, Khromova, Natalya, Kopnin, Pavel

“…We showed recently that ethyl-2-amino-pyrrole-3-carboxylates (EAPCs) exhibit potent antiproliferative activities against a broad spectrum of soft tissue…”
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Ethyl-2-amino-pyrrole-3-carboxylates are novel potent anticancer agents that affect tubulin polymerization, induce G2/M cell-cycle arrest, and effectively inhibit soft tissue cancer cell growth in vitro by Boichuk, Sergei, Galembikova, Aigul, Zykova, Svetlana, Ramazanov, Bulat, Khusnutdinov, Ramil, Dunaev, Pavel, Khaibullina, Svetlana, Lombardi, Vincent

“…Microtubules are known to be one of the most attractive and validated targets in cancer therapy. However, the clinical use of drugs that affect the dynamic…”
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