Search Results - "Aigner, Thomas"

ROR2 blockade as a therapy for osteoarthritis by Thorup, Anne-Sophie, Strachan, Danielle, Caxaria, Sara, Poulet, Blandine, Thomas, Bethan L, Eldridge, Suzanne E, Nalesso, Giovanna, Whiteford, James R, Pitzalis, Costantino, Aigner, Thomas, Corder, Roger, Bertrand, Jessica, Dell'Accio, Francesco

“…Osteoarthritis is characterized by the loss of the articular cartilage, bone remodeling, pain, and disability. No pharmacological intervention can currently…”
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Repair of Chronic Osteochondral Defects Using Predifferentiated Mesenchymal Stem Cells in an Ovine Model by Zscharnack, Matthias, Hepp, Pierre, Richter, Robert, Aigner, Thomas, Schulz, Ronny, Somerson, Jeremy, Josten, Christoph, Bader, Augustinus, Marquass, Bastian

“…Background: The use of mesenchymal stem cells (MSCs) to treat osteochondral defects caused by sports injuries or disease is of particular interest. However,…”
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A novel workflow for geothermal exploration: 3D seismic interpretation of biohermal buildups (Upper Jurassic, Molasse Basin, Germany) by Wolpert, Philipp, Aigner, Thomas, Bendias, Daniel, Beichel, Kilian, Zosseder, Kai

“…The Upper Jurassic carbonates are the prime target for deep geothermal exploration in the Molasse basin, South Germany. The carbonates have a thickness of over…”
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Sedimentary architecture and 3D ground-penetrating radar analysis of gravelly meandering river deposits (Neckar Valley, SW Germany) by KOSTIC, BORIS, AIGNER, THOMAS

“…Sedimentological outcrop analysis and sub‐surface ground‐penetrating radar (GPR) surveys are combined to characterize the three‐dimensional sedimentary…”
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NEK1 Mutations Cause Short-Rib Polydactyly Syndrome Type Majewski by Thiel, Christian, Kessler, Kristin, Giessl, Andreas, Dimmler, Arno, Shalev, Stavit A., von der Haar, Sigrun, Zenker, Martin, Zahnleiter, Diana, Stöss, Hartmut, Beinder, Ernst, Abou Jamra, Rami, Ekici, Arif B., Schröder-Kreß, Nadja, Aigner, Thomas, Kirchner, Thomas, Reis, André, Brandstätter, Johann H., Rauch, Anita

“…Defects of ciliogenesis have been implicated in a wide range of human phenotypes and play a crucial role in signal transduction and cell-cycle coordination. We…”
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Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence by Aigner, Thomas, Söder, Stefan, Gebhard, Pia M, McAlinden, Audrey, Haag, Jochen

“…The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage degradation. However, cartilage cells have a pivotal role…”
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Activation of Interleukin-1 Signaling Cascades in Normal and Osteoarthritic Articular Cartilage by Fan, Zhiyong, Söder, Stephan, Oehler, Stephan, Fundel, Katrin, Aigner, Thomas

“…Interleukin (IL)-1 is one of the most important catabolic cytokines in rheumatoid arthritis. In this study, we were interested in whether we could identify…”
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Molecular characterization of commonly used cell lines for bone tumor research: A trans-European EuroBoNet effort by Ottaviano, Laura, Schaefer, Karl-Ludwig, Gajewski, Melanie, Huckenbeck, Wolfgang, Baldus, Stefan, Rogel, Uwe, Mackintosh, Carlos, de Alava, Enrique, Myklebost, Ola, Kresse, Stine H., Meza-Zepeda, Leonardo A., Serra, Massimo, Cleton-Jansen, Anne-Marie, Hogendoorn, Pancras C. W., Buerger, Horst, Aigner, Thomas, Gabbert, Helmut E., Poremba, Christopher

“…Usage of cancer cell lines has repeatedly generated conflicting results provoked by differences among subclones or contamination with mycoplasm or other…”
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Preoperative Radiochemotherapy in Rectal Cancer: Is There an Impact of Oxaliplatin on Pathologic Complete Response and Survival Rates under "Real World" Conditions? by Grabenbauer, Alexander, Aigner, Thomas, Göbel, Holger, Leibl, Bernhard J, Lamberti, Christof, Grabenbauer, Gerhard G, Distel, Luitpold V

“…This study aimed to evaluate the benefit of additional administration of oxaliplatin during fluorouracil-based neoadjuvant radiochemotherapy (nRCT) in terms of…”
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Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage by Haag, Jochen, Aigner, Thomas

“…Bone morphogenetic proteins (BMP) play a prominent role in cartilage tissue homeostasis and perturbations of BMP signaling contribute to pathological processes…”
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PD-1 and PD-L1 expression predict regression and prognosis following neoadjuvant radiochemotherapy of oesophageal adenocarcinoma by Göbel, Holger H., Distel, Luitpold V.R., Aigner, Thomas, Büttner-Herold, Maike J., Grabenbauer, Gerhard G.

“…•Focus on pretherapeutic biopsies of patients with oesophageal adenocarcinoma.•PD-1 and PDL-1 expression predict response to RCT and prognosis.•PD-1 expression…”
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Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions by Knerr, Ina, Schubert, Steffen W., Wich, Christina, Amann, Kerstin, Aigner, Thomas, Vogler, Tina, Jung, Ronny, Dötsch, Jörg, Rascher, Wolfgang, Hashemolhosseini, Said

“…Glial cells missing a (GCMa) belongs to a new transcription factor family. Syncytin was shown to be a target gene of GCMa. Here, we demonstrate that the…”
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3-D sedimentary architecture of a Quaternary gravel delta (SW-Germany): Implications for hydrostratigraphy by Kostic, Boris, Becht, Andreas, Aigner, Thomas

“…This paper investigates a Quaternary Gilbert-type gravel delta that was formed in an ice-marginal environment at the end of the last glacial period. Outcrop,…”
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Association Between Crystals and Cartilage Degeneration in the Ankle by Muehleman, Carol, Li, Jun, Aigner, Thomas, Rappoport, Lev, Mattson, Eric, Hirschmugl, Carol, Masuda, Koichi, Rosenthal, Ann K

“…Objective Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals have been observed in synovial joints both before and after the onset of…”
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Heterogeneity patterns of Quaternary glaciofluvial gravel bodies (SW-Germany): application to hydrogeology by Heinz, Jürgen, Kleineidam, Sybille, Teutsch, Georg, Aigner, Thomas

“…The architecture of sedimentary bodies determines the heterogeneity of many aquifers. Thus, for environmental risk-assessment and quantification of clean-up…”
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FOXO3a: a novel player in thyroid carcinogenesis? by Karger, Stefan, Weidinger, Carl, Krause, Kerstin, Sheu, Sien-Yi, Aigner, Thomas, Gimm, Oliver, Schmid, Kurt-Werner, Dralle, Henning, Fuhrer, Dagmar

“…The forkhead box transcription factor FOXO3a has recently been identified as central mediator of the cellular response to oxidative stress inducing cell cycle…”
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Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells by Park, Jung, Gelse, Kolja, Frank, Susi, von der Mark, Klaus, Aigner, Thomas, Schneider, Holm

“…Background Adult primary mesenchymal cells of different origin which can be obtained with minor donor site morbidity are considered for articular cartilage…”
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SOX gene expression in human osteoarthritic cartilage by Haag, Jochen, Gebhard, Pia M, Aigner, Thomas

“…While the developmental role of the SOX transcription factors in fetal chondrocyte differentiation is well documented, much less is known about the expression…”
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Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis by Krause, Kerstin, Karger, Stefan, Sheu, Sien-Yi, Aigner, Thomas, Kursawe, Romy, Gimm, Oliver, Schmid, Kurt-Werner, Dralle, Henning, Fuhrer, Dagmar

“…We have recently found an increased expression of amyloid precursor protein (APP) in cold thyroid nodules that are difficult to classify as a truly benign…”
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Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas by Dornauer, Kerstin, Söder, Stephan, Inwards, Carry Y., Bovee, Judith. V. M. G., Aigner, Thomas

“…Dedifferentiated chondrosarcoma is an uncommon mesenchymal neoplasm comprised of two different components, low‐grade conventional chondrosarcoma and high‐grade…”
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