Search Results - "Aid, Rachida"
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Bone regeneration in both small and large preclinical bone defect models using an injectable polymer‐based substitute containing hydroxyapatite and reconstituted with saline or autologous blood
Published in Journal of biomedical materials research. Part A (01-10-2021)“…Microbeads consisting of pullulan and dextran supplemented with hydroxyapatite have recently been developed for bone tissue engineering applications. Here, we…”
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2
Tuning Physicochemical Properties of a Macroporous Polysaccharide-Based Scaffold for 3D Neuronal Culture
Published in International journal of molecular sciences (01-12-2021)“…Central nervous system (CNS) lesions are a leading cause of death and disability worldwide. Three-dimensional neural cultures in biomaterials offer more…”
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3
Bone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based Biodegradable Materials Containing Strontium-Doped Hydroxyapatite Particles
Published in International journal of molecular sciences (12-03-2023)“…The reconstruction of bones following tumor excision and radiotherapy remains a challenge. Our previous study, performed using polysaccharide-based microbeads…”
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4
Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin
Published in Biomaterials (01-02-2018)“…Injection of recombinant tissue plasminogen activator (rt-PA) is the standard drug treatment for thrombolysis. However, rt-PA shows risk of hemorrhages and…”
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5
Electrospun microporous gelatin–polycaprolactone blend tubular scaffold as a potential vascular biomaterial
Published in Polymer international (01-07-2019)“…The work reported involved the fabrication of an electrospun tubular conduit of a gelatin and polycaprolactone (PCL) blend as an adventitia‐equivalent…”
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Fucoidan promotes early step of cardiac differentiation from human embryonic stem cells and long-term maintenance of beating areas
Published in Tissue engineering. Part A (01-04-2014)“…Somatic stem cells require specific niches and three-dimensional scaffolds provide ways to mimic this microenvironment. Here, we studied a scaffold based on…”
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7
Engineered human liver based on pullulan-dextran hydrogel promotes mice survival after liver failure
Published in Materials today bio (01-04-2023)“…Liver tissue engineering approaches aim to support drug testing, assistance devices, or transplantation. However, their suitability for clinical application…”
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In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development
Published in Journal of cardiovascular translational research (01-12-2017)“…Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be…”
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Bone Spheroid Development Under Flow Conditions with Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells in a 3D Porous Hydrogel Supplemented with Hydroxyapatite
Published in Gels (18-10-2024)“…Understanding the niche interactions between blood and bone through the in vitro co-culture of osteo-competent cells and endothelial cells is a key factor in…”
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10
Planar and tubular patterning of micro and nano-topographies on poly(vinyl alcohol) hydrogel for improved endothelial cell responses
Published in Biomaterials (01-04-2016)“…Abstract Poly(vinyl alcohol) hydrogel (PVA) is a widely used material for biomedical devices, yet there is a need to enhance its biological functionality for…”
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11
Biomimicking Polysaccharide Nanofibers Promote Vascular Phenotypes: A Potential Application for Vascular Tissue Engineering
Published in Macromolecular bioscience (01-03-2012)“…The potential of electrospun pullulan/dextran (P/D) nanofibers (average diameter = 323 nm) for vascular tissue engineering applications is explored. The…”
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12
Development of 3D Hepatic Constructs Within Polysaccharide-Based Scaffolds with Tunable Properties
Published in International journal of molecular sciences (21-05-2020)“…Organoids production is a key tool for in vitro studies of physiopathological conditions, drug-induced toxicity assays, and for a potential use in regenerative…”
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13
Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis
Published in Molecules (Basel, Switzerland) (08-03-2019)“…A polyol method was used to obtain ultrasmall ZnO nanoparticles (NPs) doped with iron ions and coated with a low molecular weight fucoidan in order to perform…”
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14
Astaxanthin Complexes to Attenuate Muscle Damage after In Vivo Femoral Ischemia-Reperfusion
Published in Marine drugs (14-06-2019)“…(1) Background: Reperfusion injury refers to the cell and tissue damage induced, when blood flow is restored after an ischemic period. While reperfusion…”
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15
3D anatomical and perfusion MRI for longitudinal evaluation of biomaterials for bone regeneration of femoral bone defect in rats
Published in Scientific reports (21-07-2017)“…Magnetic Resonance Imaging (MRI) appears as a good surrogate to Computed Tomography (CT) scan as it does not involve radiation. In this context, a 3D…”
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16
Development of Polymer Microcapsules Functionalized with Fucoidan to Target P‐Selectin Overexpressed in Cardiovascular Diseases
Published in Advanced healthcare materials (01-02-2017)“…New tools for molecular imaging and targeted therapy for cardiovascular diseases are still required. Herein, biodegradable microcapsules (MCs) made of…”
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Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots
Published in ACS nano (26-12-2018)“…Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of…”
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18
Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 111In-tilmanocept
Published in EJNMMI research (03-05-2017)“…Background Atherosclerotic plaque phenotypes are classified based on the extent of macrophage infiltration into the lesions, and the presence of certain…”
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19
rtPA-loaded fucoidan polymer microbubbles for the targeted treatment of stroke
Published in Biomaterials (01-12-2023)“…Systemic injection of thrombolytic drugs is the gold standard treatment for non-invasive blood clot resolution. The most serious risks associated with the…”
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20
Fucoidan: a marine polysaccharide for SPECT diagnosis of thrombosis
Published in Frontiers in bioengineering and biotechnology (01-05-2016)“…Abstract only…”
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