Search Results - "Ahuja, G"

Porous carriers for controlled/modulated drug delivery by Ahuja, G, Pathak, K

“…Considerable research efforts have been directed in recent years towards the development of porous carriers as controlled drug delivery matrices because of…”
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Dynamic allostery-based molecular workings of kinase: peptide complexes by Ahuja, Lalima G., Aoto, Phillip C., Kornev, Alexandr P., Veglia, Gianluigi, Taylor, Susan S.

“…A dense interplay between structure and dynamics underlies the working of proteins, especially enzymes. Protein kinases are molecular switches that are…”
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Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle by Wang, Yingjie, V.S., Manu, Kim, Jonggul, Li, Geoffrey, Ahuja, Lalima G., Aoto, Philip, Taylor, Susan S., Veglia, Gianluigi

“…Enzymes accelerate the rate of chemical transformations by reducing the activation barriers of uncatalyzed reactions. For signaling enzymes, substrate…”
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A dynamic hydrophobic core orchestrates allostery in protein kinases by Kim, Jonggul, Ahuja, Lalima G, Chao, Fa-An, Xia, Youlin, McClendon, Christopher L, Kornev, Alexandr P, Taylor, Susan S, Veglia, Gianluigi

“…Eukaryotic protein kinases (EPKs) constitute a class of allosteric switches that mediate a myriad of signaling events. It has been postulated that EPKs' active…”
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CFD and experimental studies of solids hold-up distribution and circulation patterns in gas–solid fluidized beds by Ahuja, G.N., Patwardhan, A.W.

“…The hydrodynamics of a gas–solid fluidized bed was studied using a combination of experiments and CFD simulations. Experiments were conducted with…”
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Of Two Make One: The Biosynthesis of Phenazines by Mentel, Matthias, Ahuja, Ekta G, Mavrodi, Dmitri V, Breinbauer, Rolf, Thomashow, Linda S, Blankenfeldt, Wulf

“…Five easy steps: Phenazines are redox‐active bacterial secondary metabolites that possess broad‐specificity antibiotic activity and can also play an important…”
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Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases by Meharena, Hiruy S, Fan, Xiaorui, Ahuja, Lalima G, Keshwani, Malik M, McClendon, Christopher L, Chen, Angela M, Adams, Joseph A, Taylor, Susan S

“…Eukaryotic protein kinases regulate most cellular functions by phosphorylating targeted protein substrates through a highly conserved catalytic core. In the…”
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Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme by Zhang, Ping, Knape, Matthias J, Ahuja, Lalima G, Keshwani, Malik M, King, Charles C, Sastri, Mira, Herberg, Friedrich W, Taylor, Susan S

“…To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a…”
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Surgical management of atypical mycobacterial cervical lymphadenitis in an outbreak of odontological infection by Zhukhovitskaya, A., Chang, D.T., Huoh, K.C., Pham, N.S., Singh, J., Ahuja, G.S.

“…We report on our experience with surgical management of nosocomial Mycobacterium abscessus cervical lymphadenitis in the setting of an epidemic linked to a…”
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PhzA/B Catalyzes the Formation of the Tricycle in Phenazine Biosynthesis by Ahuja, Ekta G, Janning, Petra, Mentel, Matthias, Graebsch, Almut, Breinbauer, Rolf, Hiller, Wolf, Costisella, Burkhard, Thomashow, Linda S, Mavrodi, Dmitri V, Blankenfeldt, Wulf

“…Phenazines are redox-active bacterial secondary metabolites that participate in important biological processes such as the generation of toxic reactive oxygen…”
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Ultrasound-assisted lysis using recombinant tissue plasminogen activator and the EKOS EkoSonic endovascular system for treating right atrial thrombus and massive pulmonary embolism: A case study by Shammas, N W, Padaria, R, Ahuja, G

“…Right atrial thrombus in the setting of a large pulmonary embolus is rare and is associated with serious adverse events. This case report presents the role…”
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Tuning the “violin” of protein kinases: The role of dynamics‐based allostery by Ahuja, Lalima G., Taylor, Susan S., Kornev, Alexandr P.

“…The intricacies of allosteric regulation of protein kinases continue to engage the research community. Allostery, or control from a distance, is seen as a…”
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Kinases and Pseudokinases: Lessons from RAF by Shaw, Andrey S., Kornev, Alexandr P., Hu, Jiancheng, Ahuja, Lalima G., Taylor, Susan S.

“…Protein kinases are thought to mediate their biological effects through their catalytic activity. The large number of pseudokinases in the kinome and an…”
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Cardiac performance in relation to age of onset of menopause by Kaur, Manjinder, Singh, Harpreet, Ahuja, G K

“…It is well known that post menopausal women are more prone to cardiovascular diseases, osteoporosis and cancer. This study was done to detect the effect of…”
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Protein Tyrosine Phosphatases: A new paradigm in an old signaling system? by Welsh, Colin L, Pandey, Preeti, Ahuja, Lalima G

“…Protein Tyrosine Phosphatases reverse cellular signals initiated by growth factors receptors and other tyrosine kinases by dephosphorylating phosphotyrosine on…”
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Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer by Ahuja, Lalima G., Kornev, Alexandr P., McClendon, Christopher L., Veglia, Gianluigi, Taylor, Susan S.

“…The expertise of protein kinases lies in their dynamic structure, wherein they are able to modulate cellular signaling by their phosphotransferase activity…”
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Kinase Regulation by Hydrophobic Spine Assembly in Cancer by Hu, Jiancheng, Ahuja, Lalima G., Meharena, Hiruy S., Kannan, Natarajan, Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.

“…A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase…”
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Effect of exercise on rate pressure product in premenopausal and postmenopausal women with coronary artery disease by Nagpal, Sangeeta, Walia, Lily, Lata, Hem, Sood, Naresh, Ahuja, G K

“…Incidence of coronary artery disease (CAD) increases sharply after menopause in women. Rate pressure product (RPP) is a major determinant of cardiac oxygen…”
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The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion by AHUJA, H. G, FELIX, C. A, APLAN, P. D

“…The NUP98 gene is involved in 3 distinct chromosomal rearrangements, t(7;11)(p15;p15), t(2;11)(q31;p15), and inv(11)(p15q22); all of these NUP98 rearrangements…”
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Evaluation of left ventricular performance in menopausal women by Kaur, Manjinder, Ahuja, G K, Singh, Harpreet, Walia, Lily, Avasthi, Kum Kum

“…The incidence of ischemic heart disease is well documented in the literature in post menopausal women but the degree of deterioration of left ventricular…”
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