Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation

It is well documented that compounds from rhizomes of Zingiber officinale, commonly called ginger, have anti-inflammatory properties. Here, we show that ginger can exert such functions in vivo, namely in a mouse model of Th2-mediated pulmonary inflammation. The preparation of ginger aqueous extract...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 8; no. 12; pp. 1626 - 1632
Main Authors:	Ahui, Marie Louise Berthe, Champy, Pierre, Ramadan, Abdulraouf, Pham Van, Linh, Araujo, Luiza, Brou André, Konan, Diem, Séverine, Damotte, Diane, Kati-Coulibaly, Séraphin, Offoumou, Michel Atté, Dy, Michel, Thieblemont, Nathalie, Herbelin, André
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 10-12-2008 Elsevier
Subjects:	Animals Asthma - drug therapy Asthma - immunology Biological and medical sciences Cytokine Eosinophilia - prevention & control Ginger Immune response Medical sciences Mice Mice, Inbred C57BL Mice, Inbred NOD Ovalbumin - immunology Pharmacology. Drug treatments Phytotherapy Plant Extracts - therapeutic use Th1 Cells - immunology Th2 Th2 Cells - immunology Zingiber officinale Zingiber officinale - chemistry Immune response Ginger Cytokine Th2 Animal model Monocotyledones Rodentia Inflammation Respiratory system Prevention Respiratory tract Vertebrata Mammalia Mouse Angiospermae T-Lymphocyte Spermatophyta Th2 lymphocyte Zingiber officinale Zingiberaceae Immune system
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Summary:	It is well documented that compounds from rhizomes of Zingiber officinale, commonly called ginger, have anti-inflammatory properties. Here, we show that ginger can exert such functions in vivo, namely in a mouse model of Th2-mediated pulmonary inflammation. The preparation of ginger aqueous extract (Zo.Aq) was characterized by mass spectrometry as an enriched fraction of n-gingerols. Intraperitoneal injections of this extract before airway challenge of ovalbumin (OVA)-sensitized mice resulted in a marked decrease in the recruitment of eosinophils to the lungs as attested by cell counts in bronchoalveolar lavage (BAL) fluids and histological examination. Resolution of airway inflammation induced by Zo.Aq was accompanied by a suppression of the Th2 cell-driven response to allergen in vivo. Thus, IL-4, IL-5 and eotaxin levels in the lungs as well as specific IgE titres in serum were clearly diminished in ginger-treated mice relative to their controls after allergen sensitization and challenge. Finally, we found that [6]-gingerol, a major constituent of ginger, was sufficient to suppress eosinophilia in our model of inflammation. This is the first evidence that ginger can suppress Th2-mediated immune responses and might thus provide a possible therapeutic application in allergic asthma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1567-5769 1878-1705
DOI:	10.1016/j.intimp.2008.07.009