Search Results - "Ahringer, J"

Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans by Lettre, G, Kritikou, E A, Jaeggi, M, Calixto, A, Fraser, A G, Kamath, R S, Ahringer, J, Hengartner, M O

“…We used genome-wide RNA interference (RNAi) to identify genes that affect apoptosis in the C. elegans germ line. RNAi-mediated knockdown of 21 genes caused a…”
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Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7 by Ahringer, J

“…Patterning of the posterior end in animals is not well understood. Homologs of Drosophila even-skipped (eve) have a similar posterior expression pattern in…”
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The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning by Solari, F, Bateman, A, Ahringer, J

“…We show here that two functionally redundant Caenorhabditis elegans genes, egl-27 and egr-1, have a fundamental role in embryonic patterning. When both are…”
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NuRD and SIN3: histone deacetylase complexes in development by Ahringer, Julie

“…Transcription repression mediated through histone deacetylase (HDAC) complexes is widespread, and mechanisms by which HDAC complexes act have been revealed by…”
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Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in C. elegans by Poulin, G, Dong, Y, Fraser, AG, Hopper, NA, Ahringer, J

“…Correction to: The EMBO Journal (2005) 24, 2613-2623. doi:10.1038/sj.emboj.7600726…”
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Distinct roles for G alpha and G beta gamma in regulating spindle position and orientation in Caenorhabditis elegans embryos by Gotta, M, Ahringer, J

“…Correct placement and orientation of the mitotic spindle is essential for segregation of localized components and positioning of daughter cells. Although these…”
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Maternal control of a zygotic patterning gene in Caenorhabditis elegans by Ahringer, J

“…The transition from maternal to zygotic gene control is a key process in embryogenesis. Although many maternal effect genes have been studied in the C. elegans…”
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Embryonic tissue differentiation in Caenorhabditis elegans requires dif‐1, a gene homologous to mitochondrial solute carriers by Ahringer, J.

“…The dif‐1 gene was identified in a general screen for maternal‐effect embryonic lethal (Mel) mutants. dif‐1 mutant embryos complete gastrulation and embryonic…”
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PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans by Goedert, M, Baur, C P, Ahringer, J, Jakes, R, Hasegawa, M, Spillantini, M G, Smith, M J, Hill, F

“…Tau, MAP2 and MAP4 are structural microtubule-associated proteins (MAPs) that promote the assembly and stability of microtubules. They share three or four…”
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Control of cell polarity and mitotic spindle positioning in animal cells by Ahringer, Julie

“…Cell polarity is an essential feature of many animal cells. It is critical for epithelial formation and function, for correct partitioning of fate-determining…”
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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans by Kenyon, Cynthia, Murphy, Coleen T, McCarroll, Steven A, Bargmann, Cornelia I, Fraser, Andrew, Kamath, Ravi S, Ahringer, Julie, Li, Hao

“…Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription factor, influences the rate of ageing of Caenorhabditis elegans in…”
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Broad chromosomal domains of histone modification patterns in C. elegans by Liu, Tao, Rechtsteiner, Andreas, Egelhofer, Thea A, Vielle, Anne, Latorre, Isabel, Cheung, Ming-Sin, Ercan, Sevinc, Ikegami, Kohta, Jensen, Morten, Kolasinska-Zwierz, Paulina, Rosenbaum, Heidi, Shin, Hyunjin, Taing, Scott, Takasaki, Teruaki, Iniguez, A Leonardo, Desai, Arshad, Dernburg, Abby F, Kimura, Hiroshi, Lieb, Jason D, Ahringer, Julie, Strome, Susan, Liu, X Shirley

“…Chromatin immunoprecipitation identifies specific interactions between genomic DNA and proteins, advancing our understanding of gene-level and chromosome-level…”
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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity by Ruvkun, Gary, Lee, Siu Sylvia, Lee, Raymond Y.N, Fraser, Andrew G, Kamath, Ravi S, Ahringer, Julie

“…We report a systematic RNA interference (RNAi) screen of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan. We found that genes…”
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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi by Ahringer, Julie, Kamath, Ravi S, Fraser, Andrew G, Dong, Yan, Poulin, Gino, Durbin, Richard, Gotta, Monica, Kanapin, Alexander, Le Bot, Nathalie, Moreno, Sergio, Sohrmann, Marc, Welchman, David P, Zipperlen, Peder

“…A principal challenge currently facing biologists is how to connect the complete DNA sequence of an organism to its development and behaviour. Large-scale…”
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The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures by Chen, Ron A-J, Down, Thomas A, Stempor, Przemyslaw, Chen, Q Brent, Egelhofer, Thea A, Hillier, LaDeana W, Jeffers, Tess E, Ahringer, Julie

“…RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis elegans. The initial 5' end of most protein-coding transcripts is removed…”
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Functional genomic analysis of C. elegans chromosome I by systematic RNA interference by Ahringer, Julie, Fraser, Andrew G, Kamath, Ravi S, Zipperlen, Peder, Martinez-Campos, Maruxa, Sohrmann, Marc

“…Complete genomic sequence is known for two multicellular eukaryotes, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster, and it will…”
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Rates of Behavior and Aging Specified by Mitochondrial Function during Development by Dillin, Andrew, Hsu, Ao-Lin, Arantes-Oliveira, Nuno, Lehrer-Graiwer, Joshua, Hsin, Honor, Fraser, Andrew G., Kamath, Ravi S., Ahringer, Julie, Kenyon, Cynthia

“…To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5'-triphosphate…”
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Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes by Ruvkun, Gary, Ashrafi, Kaveh, Chang, Francesca Y, Watts, Jennifer L, Fraser, Andrew G, Kamath, Ravi S, Ahringer, Julie

“…Regulation of body fat storage involves signalling between centres that regulate feeding in the brain and sites of fat storage and use in the body. Here we…”
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Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation by Garigan, Delia, Hsu, Ao-Lin, Fraser, Andrew G, Kamath, Ravi S, Ahringer, Julie, Kenyon, Cynthia

“…The genetic analysis of life span has revealed many interesting genes and pathways; however, our understanding of aging has been limited by the lack of a way…”
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Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi by Simmer, Femke, Tijsterman, Marcel, Parrish, Susan, Koushika, Sandhya P, Nonet, Michael L, Fire, Andrew, Ahringer, Julie, Plasterk, Ronald H.A

“…RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans [1]. Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss…”
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